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==Overview==
==Overview==


Common causes of squamous cell carcinoma of the lung include precursor lesions, such as metaplasia or dysplasia induced by smoking, asbestos exposure, ionizing radiation, atmospheric pollution, and chronic interstitial pneumonitis. Less common causes of non-small cell lung cancer include chromium and nickel exposure, vinyl chloride exposure, and inorganic arsenic exposure.<ref name="NSCL">National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified January 22. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq. Accessed February 23, 2015</ref>
Common causes of squamous cell carcinoma of the lung include precursor [[Lesion|lesions]], such as [[metaplasia]] or [[dysplasia]] induced by [[smoking]], [[asbestos]] exposure, [[ionizing radiation]], atmospheric pollution, and chronic [[interstitial pneumonitis]]. Less common causes of non-small cell lung cancer include [[chromium]] and [[nickel]] exposure, [[vinyl chloride]] exposure, and inorganic [[arsenic]] exposure.


==Common Causes==
===Common Causes===
*Common causes of squamous cell carcinoma of the lung include precursor lesions, such as metaplasia or dysplasia.  
*Common causes of squamous cell carcinoma of the lung include [[precursor]] [[Lesion|lesions]], such as [[metaplasia]] or [[dysplasia]].  
*Precursor lesions of non-small cell lung cancer include:<ref name="NSCL">National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified January 22. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq. Accessed February 23, 2015</ref>
*Precursor lesions of non-small cell lung cancer include:<ref name="NSCL">National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified January 22. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq. Accessed February 23, 2015</ref><ref name="pmid17873159">{{cite journal |vauthors=Alberg AJ, Ford JG, Samet JM |title=Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition) |journal=Chest |volume=132 |issue=3 Suppl |pages=29S–55S |date=September 2007 |pmid=17873159 |doi=10.1378/chest.07-1347 |url=}}</ref><ref name="pmid15894687">{{cite journal |vauthors=Tulunay OE, Hecht SS, Carmella SG, Zhang Y, Lemmonds C, Murphy S, Hatsukami DK |title=Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers |journal=Cancer Epidemiol. Biomarkers Prev. |volume=14 |issue=5 |pages=1283–6 |date=May 2005 |pmid=15894687 |doi=10.1158/1055-9965.EPI-04-0570 |url=}}</ref><ref name="pmid14693752">{{cite journal |vauthors=Anderson KE, Kliris J, Murphy L, Carmella SG, Han S, Link C, Bliss RL, Puumala S, Murphy SE, Hecht SS |title=Metabolites of a tobacco-specific lung carcinogen in nonsmoking casino patrons |journal=Cancer Epidemiol. Biomarkers Prev. |volume=12 |issue=12 |pages=1544–6 |date=December 2003 |pmid=14693752 |doi= |url=}}</ref><ref name="pmid20634481">{{cite journal |vauthors=Friedman DL, Whitton J, Leisenring W, Mertens AC, Hammond S, Stovall M, Donaldson SS, Meadows AT, Robison LL, Neglia JP |title=Subsequent neoplasms in 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study |journal=J. Natl. Cancer Inst. |volume=102 |issue=14 |pages=1083–95 |date=July 2010 |pmid=20634481 |pmc=2907408 |doi=10.1093/jnci/djq238 |url=}}</ref>
:*Smoking(active/passive)
:*[[Smoking]](active/passive)
:*Asbestos exposure
:*[[Asbestos]] exposure
:*Chronic interstitial pneumonitis
:*Chronic [[interstitial pneumonitis]]
:*Ionizing radiation
:*Ionizing [[radiation]]
:*Atmospheric pollution
:*Atmospheric [[pollution]]
 
==Less Common Causes==
*Less common causes of squamous cell carcinoma of the lung include:<ref name="NSCL">National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified January 22. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq. Accessed February 23, 2015</ref>
:*Inorganic arsenic exposure
:*Chromium, nickel exposure
:*Vinyl chloride exposure
:*Radon exposure
:*Halogen ether exposure


===Less Common Causes===
*Less common causes of squamous cell carcinoma of the lung include:<ref name="NSCL">National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified January 22. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq. Accessed February 23, 2015</ref><ref name="pmid19418618">{{cite journal |vauthors=Straif K, Benbrahim-Tallaa L, Baan R, Grosse Y, Secretan B, El Ghissassi F, Bouvard V, Guha N, Freeman C, Galichet L, Cogliano V |title=A review of human carcinogens--Part C: metals, arsenic, dusts, and fibres |journal=Lancet Oncol. |volume=10 |issue=5 |pages=453–4 |date=May 2009 |pmid=19418618 |doi= |url=}}</ref><ref name="pmid19129153">{{cite journal |vauthors=Gray A, Read S, McGale P, Darby S |title=Lung cancer deaths from indoor radon and the cost effectiveness and potential of policies to reduce them |journal=BMJ |volume=338 |issue= |pages=a3110 |date=January 2009 |pmid=19129153 |pmc=2769068 |doi= |url=}}</ref><ref name="pmid18927099">{{cite journal |vauthors=Berrington de González A, Kim KP, Berg CD |title=Low-dose lung computed tomography screening before age 55: estimates of the mortality reduction required to outweigh the radiation-induced cancer risk |journal=J Med Screen |volume=15 |issue=3 |pages=153–8 |date=2008 |pmid=18927099 |pmc=2782431 |doi=10.1258/jms.2008.008052 |url=}}</ref>
**Inorganic [[arsenic]] exposure
**[[Chromium]], [[nickel]] exposure
**Vinyl chloride exposure
**[[Radon]] exposure
**[[Halogen]] [[ether]] exposure
**[[Radiation-induced lung injury|Radiation exposure]]


==References==
==References==

Latest revision as of 16:30, 26 April 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2] Maria Fernanda Villarreal, M.D. [3]

Overview

Common causes of squamous cell carcinoma of the lung include precursor lesions, such as metaplasia or dysplasia induced by smoking, asbestos exposure, ionizing radiation, atmospheric pollution, and chronic interstitial pneumonitis. Less common causes of non-small cell lung cancer include chromium and nickel exposure, vinyl chloride exposure, and inorganic arsenic exposure.

Common Causes

Less Common Causes

References

  1. 1.0 1.1 National Cancer Institute: PDQ® Non-Small Cell Lung Cancer Treatment. Bethesda, MD: National Cancer Institute. Date last modified January 22. http://www.cancer.gov/types/lung/hp/non-small-cell-lung-treatment-pdq. Accessed February 23, 2015
  2. Alberg AJ, Ford JG, Samet JM (September 2007). "Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition)". Chest. 132 (3 Suppl): 29S–55S. doi:10.1378/chest.07-1347. PMID 17873159.
  3. Tulunay OE, Hecht SS, Carmella SG, Zhang Y, Lemmonds C, Murphy S, Hatsukami DK (May 2005). "Urinary metabolites of a tobacco-specific lung carcinogen in nonsmoking hospitality workers". Cancer Epidemiol. Biomarkers Prev. 14 (5): 1283–6. doi:10.1158/1055-9965.EPI-04-0570. PMID 15894687.
  4. Anderson KE, Kliris J, Murphy L, Carmella SG, Han S, Link C, Bliss RL, Puumala S, Murphy SE, Hecht SS (December 2003). "Metabolites of a tobacco-specific lung carcinogen in nonsmoking casino patrons". Cancer Epidemiol. Biomarkers Prev. 12 (12): 1544–6. PMID 14693752.
  5. Friedman DL, Whitton J, Leisenring W, Mertens AC, Hammond S, Stovall M, Donaldson SS, Meadows AT, Robison LL, Neglia JP (July 2010). "Subsequent neoplasms in 5-year survivors of childhood cancer: the Childhood Cancer Survivor Study". J. Natl. Cancer Inst. 102 (14): 1083–95. doi:10.1093/jnci/djq238. PMC 2907408. PMID 20634481.
  6. Straif K, Benbrahim-Tallaa L, Baan R, Grosse Y, Secretan B, El Ghissassi F, Bouvard V, Guha N, Freeman C, Galichet L, Cogliano V (May 2009). "A review of human carcinogens--Part C: metals, arsenic, dusts, and fibres". Lancet Oncol. 10 (5): 453–4. PMID 19418618.
  7. Gray A, Read S, McGale P, Darby S (January 2009). "Lung cancer deaths from indoor radon and the cost effectiveness and potential of policies to reduce them". BMJ. 338: a3110. PMC 2769068. PMID 19129153.
  8. Berrington de González A, Kim KP, Berg CD (2008). "Low-dose lung computed tomography screening before age 55: estimates of the mortality reduction required to outweigh the radiation-induced cancer risk". J Med Screen. 15 (3): 153–8. doi:10.1258/jms.2008.008052. PMC 2782431. PMID 18927099.


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