Hepatitis C classification: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
(Created page with "__NOTOC__ {{Hepatitis C}} {{CMG}} ==Overview== ==Classification== ==References== {{Reflist|2}}")
 
m (Bot: Removing from Primary care)
 
(18 intermediate revisions by 5 users not shown)
Line 3: Line 3:
{{CMG}}
{{CMG}}
==Overview==
==Overview==
HCV may be classified according to the [[genotype]] into 6 major genotypes and >60 subtypes.


==Classification==
==Classification==
Shortly after the discovery of the hepatitis C virus, various isolations revealed that the virus is genetically diverse. According to the [[genomic sequence]] heterogeneity, HCV has been classified into 11 [[genotype|genotypes]] (6 of which are considered major), designated 1-11; 18 assigned subtypes, designated a, b, c, etc.; tens of others pending assignment; and hundreds of strains, numbered 1, 2, 3, etc.<ref name="pmid24115039">{{cite journal| author=Smith DB, Bukh J, Kuiken C, Muerhoff AS, Rice CM, Stapleton JT et al.| title=Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource. | journal=Hepatology | year= 2014 | volume= 59 | issue= 1 | pages= 318-27 | pmid=24115039 | doi=10.1002/hep.26744 | pmc=PMC4063340 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24115039  }} </ref>
In less than 10 years, the number of assigned subtypes increased from only 18 in 2005 to 67 in 2014. Similarly, the number of complete [[coding sequences]] increased from just 238 to at least 1,300.<ref name="pmid24115039">{{cite journal| author=Smith DB, Bukh J, Kuiken C, Muerhoff AS, Rice CM, Stapleton JT et al.| title=Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource. | journal=Hepatology | year= 2014 | volume= 59 | issue= 1 | pages= 318-27 | pmid=24115039 | doi=10.1002/hep.26744 | pmc=PMC4063340 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24115039  }} </ref> The number of incomplete sequences is currently greater than 500, some of which are expected be completed in the near future.
The following table shows the different HCV genotypes and their corresponding [[loci]]/isolates:<ref name="pmid24115039">{{cite journal| author=Smith DB, Bukh J, Kuiken C, Muerhoff AS, Rice CM, Stapleton JT et al.| title=Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource. | journal=Hepatology | year= 2014 | volume= 59 | issue= 1 | pages= 318-27 | pmid=24115039 | doi=10.1002/hep.26744 | pmc=PMC4063340 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24115039  }} </ref>
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
|+HCV Major Genotypes and Subtypes'''''
! style="background: #4479BA; width: 120px;" | {{fontcolor|#FFF|Genotype}}
! style="background: #4479BA; width: 250px;" | {{fontcolor|#FFF|Endemicity}}
! style="background: #4479BA; width: 250px;" | {{fontcolor|#FFF|Loci/Isolates}}
|-
| style="padding: 5px 5px; background: #DCDCDC;" |'''Genotype 1'''
|style="padding: 5px 5px; background: #F5F5F5;" |Most common (60% of all HCV infections). It has a worldwide distribution, but mostly in Northern Europe, Northern America, Southern and Eastern Europe, and Japan
| style="padding: 5px 5px; background: #F5F5F5;" |
*a: HPCPLYPRE, HPCCGAA
*b: HPCJCG, HPCHUMR
*c: HPCCGS, AY051292
*e: 148636
*g: 1804
*h: EBW443, EBW9 
*l: 136142, EBW424
|-
| style="padding: 5px 5px; background: #DCDCDC;" |'''Genotype 2'''
|style="padding: 5px 5px; background: #F5F5F5;" |Second most common after genotype 1. It has a worldwide distribution, but mostly in Northern Europe, Northern America, Southern and Eastern Europe, and Japan
| style="padding: 5px 5px; background: #F5F5F5;" |
*a: HPCPOLP, JFH-1
*b: HPCJ8G, JPUT971017
*c: BEBE1
*d: QC259 
*e: QC64 
*i: D54
*j: C1799
*k: VAT96
*m: QC178, BID-G1314
*q: 963, 852
*r: QC283
|-
| style="padding: 5px 5px; background: #DCDCDC;" |'''Genotype 3'''
|style="padding: 5px 5px; background: #F5F5F5;" |South-East Asia
| style="padding: 5px 5px; background: #F5F5F5;" |
*a: HPCEGS, HPCK3A
*b: HPCFG
*g: BID-G1243, QC260
*h: QC29
*i: IND-HCV, BID-G1244
*k: HPCJK049E1, QC105
|-
| style="padding: 5px 5px; background: #DCDCDC;" |'''Genotype 4'''
|style="padding: 5px 5px; background: #F5F5F5;" |Middle East, especially Egypt, and Central Africa
| style="padding: 5px 5px; background: #F5F5F5;" |
*a: ED43
*b: QC264
*c: QC381 
*d: 03-18, QC382
*f: IFBT88, PS6
*g: QC193
*k: PS3, QC383
*l: QC274
*m: QC249
*n: QC97
*o: QC93
*p: QC139
*q: QC262 
*r: QC384 
*t: QC155
*v: CYHCV073, BID-G1248
*w: P212, P245
|-
| style="padding: 5px 5px; background: #DCDCDC;" |'''Genotype 5'''
|style="padding: 5px 5px; background: #F5F5F5;" |South Africa
| style="padding: 5px 5px; background: #F5F5F5;" |
*a: EUH1480, SA13
|-
| style="padding: 5px 5px; background: #DCDCDC;" |'''Genotype 6'''
|style="padding: 5px 5px; background: #F5F5F5;" |Asia
| style="padding: 5px 5px; background: #F5F5F5;" |
*6a: EUHK2,6a33
*6b: Th580
*6c: Th846
*6d: VN235
*6e: GX004
*6f: C-0044
*6g: HPCJK046E2 
*6h: VN004
*6i: Th602
*6j: Th553
*6k: VN405
*6l: 537796
*6m: B4/92
*6n: KM42, D86/93
*6o: QC227 
*6p: QC216
*6q: QC99
*6r: QC245 
*6s: QC66
*6t: VT21, D49 
*6u: D83
*6v: NK46, KMN-02
*6w: GZ52557, D140
*6xa: DH012, DH028
|-
|}
<sup><center>Adapted from Smith DB, Bukh J, Kuiken C, et al. Expanded Classification of Hepatitis C Virus Into 7 Genotypes and 67 Subtypes: Updated Criteria and Genotype Assignment Web Resource. ''Hepatology''.2014;59(1):318-327</center></sup>


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
{{WH}}
{{WS}}
[[Category:Gastroenterology]]
[[Category:FinalQCRequired]]
[[Category:Emergency mdicine]]
[[Category:Disease]]
[[Category:Up-To-Date]]
[[Category:Infectious disease]]
[[Category:Hepatology]]

Latest revision as of 22:05, 29 July 2020

Hepatitis Main Page

Hepatitis C

Home

Patient Info

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Epidemiology & Demographics

Risk Factors

Screening

Differentiating Hepatitis C from other Diseases

Natural History, Complications & Prognosis

Diagnosis

History & Symptoms

Physical Examination

Lab Tests

Electrocardiogram

Chest X Ray

CT

MRI

Ultrasound

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Future or Investigational Therapies

Hepatitis C classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Hepatitis C classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Hepatitis C classification

CDC on Hepatitis C classification

Hepatitis C classification in the news

Blogs on Hepatitis C classification

Directions to Hospitals Treating Hepatitis C

Risk calculators and risk factors for Hepatitis C classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

HCV may be classified according to the genotype into 6 major genotypes and >60 subtypes.

Classification

Shortly after the discovery of the hepatitis C virus, various isolations revealed that the virus is genetically diverse. According to the genomic sequence heterogeneity, HCV has been classified into 11 genotypes (6 of which are considered major), designated 1-11; 18 assigned subtypes, designated a, b, c, etc.; tens of others pending assignment; and hundreds of strains, numbered 1, 2, 3, etc.[1]

In less than 10 years, the number of assigned subtypes increased from only 18 in 2005 to 67 in 2014. Similarly, the number of complete coding sequences increased from just 238 to at least 1,300.[1] The number of incomplete sequences is currently greater than 500, some of which are expected be completed in the near future.

The following table shows the different HCV genotypes and their corresponding loci/isolates:[1]

HCV Major Genotypes and Subtypes
Genotype Endemicity Loci/Isolates
Genotype 1 Most common (60% of all HCV infections). It has a worldwide distribution, but mostly in Northern Europe, Northern America, Southern and Eastern Europe, and Japan
  • a: HPCPLYPRE, HPCCGAA
  • b: HPCJCG, HPCHUMR
  • c: HPCCGS, AY051292
  • e: 148636
  • g: 1804
  • h: EBW443, EBW9
  • l: 136142, EBW424
Genotype 2 Second most common after genotype 1. It has a worldwide distribution, but mostly in Northern Europe, Northern America, Southern and Eastern Europe, and Japan
  • a: HPCPOLP, JFH-1
  • b: HPCJ8G, JPUT971017
  • c: BEBE1
  • d: QC259
  • e: QC64
  • i: D54
  • j: C1799
  • k: VAT96
  • m: QC178, BID-G1314
  • q: 963, 852
  • r: QC283
Genotype 3 South-East Asia
  • a: HPCEGS, HPCK3A
  • b: HPCFG
  • g: BID-G1243, QC260
  • h: QC29
  • i: IND-HCV, BID-G1244
  • k: HPCJK049E1, QC105
Genotype 4 Middle East, especially Egypt, and Central Africa
  • a: ED43
  • b: QC264
  • c: QC381
  • d: 03-18, QC382
  • f: IFBT88, PS6
  • g: QC193
  • k: PS3, QC383
  • l: QC274
  • m: QC249
  • n: QC97
  • o: QC93
  • p: QC139
  • q: QC262
  • r: QC384
  • t: QC155
  • v: CYHCV073, BID-G1248
  • w: P212, P245
Genotype 5 South Africa
  • a: EUH1480, SA13
Genotype 6 Asia
  • 6a: EUHK2,6a33
  • 6b: Th580
  • 6c: Th846
  • 6d: VN235
  • 6e: GX004
  • 6f: C-0044
  • 6g: HPCJK046E2
  • 6h: VN004
  • 6i: Th602
  • 6j: Th553
  • 6k: VN405
  • 6l: 537796
  • 6m: B4/92
  • 6n: KM42, D86/93
  • 6o: QC227
  • 6p: QC216
  • 6q: QC99
  • 6r: QC245
  • 6s: QC66
  • 6t: VT21, D49
  • 6u: D83
  • 6v: NK46, KMN-02
  • 6w: GZ52557, D140
  • 6xa: DH012, DH028
Adapted from Smith DB, Bukh J, Kuiken C, et al. Expanded Classification of Hepatitis C Virus Into 7 Genotypes and 67 Subtypes: Updated Criteria and Genotype Assignment Web Resource. Hepatology.2014;59(1):318-327

References

  1. ↑ 1.0 1.1 1.2 Smith DB, Bukh J, Kuiken C, Muerhoff AS, Rice CM, Stapleton JT; et al. (2014). "Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource". Hepatology. 59 (1): 318–27. doi:10.1002/hep.26744. PMC 4063340. PMID 24115039.


Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Hepatitis_C_classification&oldid=1639152"