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| __NOTOC__
| | #REDIRECT [[Penbutolol#Nonclinical Toxicology]] |
| {{Penbutolol}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Nonclinical Toxicology==
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| Studies in rats indicated that the combination of penbutolol, [[triamterene]], and [[hydrochlorothiazide]] (up to 40, 50 and 25 mg/kg respectively) increased the incidence and severity of renal tubular dilation and regeneration when compared to that in rats treated only with [[triamterene]] and [[hydrochlorothiazide]]. Dogs administered the same doses of [[triamterene]] and hydrochlorothiazide alone and in combination with penbutolol had an increase in serum alkaline phosphatase and serum alanine transferase, but there were no gross or microscopic abnormalities observed. No significant toxicologic findings were observed in rats and dogs treated with a combination of penbutolol and hydrochlorothiazide.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = LEVATOL (PENBUTOLOL SULFATE) TABLET [ACTIENT PHARMACEUTICALS, LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=d241fc80-2c55-4dbb-bdb2-44f731afa137 | publisher = | date = | accessdate = 4 February 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Cardiovascular Drugs]]
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