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| __NOTOC__
| | #REDIRECT [[Carvedilol#Overdosage]] |
| {{Carvedilol}}
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| {{CMG}}; {{AE}} {{AZ}}
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| ==Overdosage==
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| Overdosage may cause severe [[hypotension]], [[bradycardia]], [[cardiac insufficiency]], [[cardiogenic shock]], and [[cardiac arrest]]. Respiratory problems, bronchospasms, vomiting, lapses of consciousness, and generalized [[seizures]] may also occur.
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| :*The patient should be placed in a '''supine position''' and, where necessary and '''kept under observation'''
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| :*The patient should be treated under intensive-care conditions.
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| :*'''Gastric lavage''' or pharmacologically induced [[emesis]] may be used shortly after ingestion.
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| The following agents may be '''administered for excessive [[bradycardia]]''':
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| :* Atropine, 2 mg IV.
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| '''To support cardiovascular function:'''
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| :*Glucagon, 5 to 10 mg IV rapidly over 30 seconds, followed by a continuous infusion of 5 mg/hour:*sympathomimetics (dobutamine, isoprenaline, adrenaline) at doses according to body weight and effect.
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| '''If peripheral vasodilation dominates:'''
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| :*Administer adrenaline or noradrenaline with continuous monitoring of circulatory conditions.
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| '''For therapy-resistant [[bradycardia]]'''
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| :*pacemaker therapy should be performed.
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| '''For bronchospasm'''
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| :*β-sympathomimetics (as aerosol or IV) or [[Aminophylline]] IV should be given.
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| '''In the event of [[seizures]]'''
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| :*Administer slow IV injection of [[diazepam]] or [[clonazepam]] is recommended.
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| '''NOTE:''' In the event of severe intoxication where there are symptoms of shock, treatment with antidotes must be continued for a sufficiently '''long period of time consistent with the 7-10 hour half-life of carvedilol'''.
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| Cases of overdosage with COREG alone or in combination with other drugs have been reported. Quantities ingested in some cases exceeded 1,000 milligrams. Symptoms experienced included low blood pressure and heart rate. '''Standard supportive treatment''' was provided and individuals recovered.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = COREG (CARVEDILOL) TABLET, FILM COATED [GLAXOSMITHKLINE LLC] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c57982f2-c7da-488a-7ea9-b9609439ac68#nlm34089-3 | publisher = | date = | accessdate = }}</ref>
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| ==References==
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| {{Reflist}}
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| {{FDA}}
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| [[Category:Drugs]]
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| ==References==
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| {{Reflist}}
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| {{FDA}}
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| | [[Category:Beta Blockers]] |
| | [[Category:Cardiovascular Drugs]] |
| [[Category:Drugs]] | | [[Category:Drugs]] |