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| __NOTOC__
| | #REDIRECT [[Amlodipine#Overdosage]] |
| {{Amlodipine}}
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| {{CMG}}; {{AE}} {{AK}}
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| == OVERDOSAGE==
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| Overdosage might be expected to cause excessive peripheral vasodilation with marked [[hypotension]] and possibly a [[reflex tachycardia]]. In humans, experience with intentional overdosage of NORVASC is limited. | |
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| Single oral doses of amlodipine maleate equivalent to 40 mg amlodipine/kg and 100 mg amlodipine/kg in mice and rats, respectively, caused deaths. Single oral amlodipine maleate doses equivalent to 4 or more mg amlodipine/kg or higher in dogs (11 or more times the maximum recommended human dose on a mg/m2 basis) caused a marked peripheral vasodilation and hypotension.
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| If massive overdose should occur, initiate active cardiac and respiratory monitoring. Frequent blood pressure measurements are essential. Should [[hypotension]] occur, provide cardiovascular support including elevation of the extremities and the judicious administration of fluids. If [[hypotension]] remains unresponsive to these conservative measures, consider administration of [[vasopressors]] (such as [[phenylephrine]]) with attention to circulating volume and urine output. As NORVASC is highly protein bound, [[hemodialysis]] is not likely to be of benefit.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = NORVASC (AMLODIPINE BESYLATE) TABLET [CARDINAL HEALTH] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=44e5ad27-e062-461a-bdf4-192d852fbc49#nlm42230-3 | publisher = | date = | accessdate = 6 March 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Cardiovascular Drugs]] | | [[Category:Cardiovascular Drugs]] |
| [[Category:Drugs]] | | [[Category:Drugs]] |