Penicillin G sodium: Difference between revisions

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==Overview==
==Overview==
 
Penicillin G sodium, a water soluble benzylpenicillin,itis bactericidal against penicillin-susceptible microorganisms during the stage of active multiplication.  Penicillin G is typically given [[parenteral|parenterally]], bypassing the intestines, because it is unstable in the highly acidic stomach. Because the drug is given parenterally, higher tissue concentrations of penicillin G can be achieved than is possible with phenoxymethylpenicillin.  These higher concentrations translate to increased antibacterial activity.


==Category==
==Category==

Latest revision as of 06:45, 4 January 2014

Penicillin G sodium
PENICILLIN G SODIUM® FDA Package Insert
Description
Clinical Pharmacology
Microbiology
Indications and Usage
Contraindications
Warnings and Precautions
Adverse Reactions
Drug Interactions
Dosage and Administration
How Supplied
Labels and Packages

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamed Moubarak, M.D. [2]

Overview

Penicillin G sodium, a water soluble benzylpenicillin,itis bactericidal against penicillin-susceptible microorganisms during the stage of active multiplication. Penicillin G is typically given parenterally, bypassing the intestines, because it is unstable in the highly acidic stomach. Because the drug is given parenterally, higher tissue concentrations of penicillin G can be achieved than is possible with phenoxymethylpenicillin. These higher concentrations translate to increased antibacterial activity.

Category

Penicillinase-resistant penicillins

US Brand Names

PENICILLIN G SODIUM®

FDA Package Insert

Description | Clinical Pharmacology | Microbiology | Indications and Usage | Contraindications | Warnings and Precautions | Adverse Reactions | Drug Interactions | Dosage and Administration | How Supplied | Labels and Packages

Mechanism of Action

Penicillin G exerts a bactericidal action against penicillin-susceptible microorganisms during the stage of active multiplication. It acts through the inhibition of biosynthesis of cell-wall peptidoglycan, rendering the cell wall osmotically unstable resulting in death of the bacterium.

References