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| __NOTOC__
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| {{SI}}
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| {{CMG}}
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| {{SK}}; NL, neonatal lupus
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| == Overview ==
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| Neonatal lupus (NL) is an autoimmune disease of neonates that results from passive transfer of autoantibodies from the mother to the fetus. It occurs in about 1 to 2 percent of babies born to mothers with autoimmune disease, primarily systemic lupus erythematosus (SLE) and Sjögren’s syndrome, and antibodies to SSA/Ro and/or SSB/La.<ref name="pmid20012231">{{cite journal| author=Brucato A, Cimaz R, Caporali R, Ramoni V, Buyon J| title=Pregnancy outcomes in patients with autoimmune diseases and anti-Ro/SSA antibodies. | journal=Clin Rev Allergy Immunol | year= 2011 | volume= 40 | issue= 1 | pages= 27-41 | pmid=20012231 | doi=10.1007/s12016-009-8190-6 | pmc=PMC3558034 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20012231 }} </ref><ref name="pmid19852749">{{cite journal| author=Buyon JP| title=Updates on lupus and pregnancy. | journal=Bull NYU Hosp Jt Dis | year= 2009 | volume= 67 | issue= 3 | pages= 271-5 | pmid=19852749 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19852749 }} </ref>
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| ==Historical Perspective==
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| ==Classification==
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| == Pathophysiology==
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| Neonatal lupus (NL) is presumed to result from transplacental passage of maternal anti-SSA/Ro and/or anti-SSB/La antibodies. The precise mechanism of injury to specific tissues, such as the skin and heart, is not known.
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| === Genetics ===
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| === Associated Conditions===
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| ===Gross Pathology===
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| ===Microscopic Pathology===
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| ==Causes==
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| ===Life Threatening Causes===
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| Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
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| ===Common Causes===
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| ===Causes by Organ System===
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| {|style="width:80%; height:100px" border="1"
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| |style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
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| |style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Chemical / poisoning'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Dermatologic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Drug Side Effect'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Ear Nose Throat'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Endocrine'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Environmental'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Gastroenterologic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Genetic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Hematologic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Iatrogenic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Infectious Disease'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Musculoskeletal / Ortho'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Neurologic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Nutritional / Metabolic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Obstetric/Gynecologic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Oncologic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Opthalmologic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Overdose / Toxicity'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Psychiatric'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Pulmonary'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Renal / Electrolyte'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Rheum / Immune / Allergy'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Sexual'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Trauma'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Urologic'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Dental'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |-bgcolor="LightSteelBlue"
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| | '''Miscellaneous'''
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| |bgcolor="Beige"| No underlying causes
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| |-
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| |}
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| ===Causes in Alphabetical Order===
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| *A...
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| *Z...
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| Make sure that each diagnosis is linked to a page.
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| ==Differentiating type page name here from other Diseases==
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| == Epidemiology and Demographics ==
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| ===Age===
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| ===Gender===
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| ===Race===
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| ===Developed Countries===
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| ===Developing Countries===
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| == Risk Factors ==
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| == Screening ==
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| == Natural History, Complications and Prognosis==
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| == Diagnosis ==
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| ===History===
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| A directed history should be obtained to ascertain
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| === Symptoms ===
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| "Type symptom here" is pathognomonic of the "type disease name here".
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| "Type non specific symptoms" may be present.
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| ===Past Medical History===
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| ===Family History===
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| ===Social History===
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| ====Occupational====
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| ====Alcohol====
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| The frequency and amount of alcohol consumption should be characterized.
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| ====Drug Use====
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| ====Smoking====
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| ===Allergies===
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| === Physical Examination ===
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| ==== Appearance of the Patient ====
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| ====Vital Signs====
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| ====Skin====
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| ====Head====
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| ==== Eyes ====
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| ==== Ear ====
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| ====Nose====
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| ====Mouth====
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| ====Throat ====
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| ==== Heart ====
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| ==== Lungs ====
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| ==== Abdomen ====
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| ==== Extremities ====
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| ==== Neurologic ====
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| ====Genitals====
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| ==== Other ====
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| === Laboratory Findings ===
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| ==== Electrolyte and Biomarker Studies ====
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| ==== Electrocardiogram ====
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| ==== Chest X Ray ====
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| ====CT ====
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| ==== MRI ====
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| ==== Echocardiography or Ultrasound ====
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| ==== Other Imaging Findings ====
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| === Other Diagnostic Studies ===
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| == Treatment ==
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| === Pharmacotherapy ===
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| ==== Acute Pharmacotherapies ====
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| ==== Chronic Pharmacotherapies ====
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| === Surgery and Device Based Therapy ===
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| ==== Indications for Surgery ====
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| ==== Pre-Operative Assessment ====
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| ==== Post-Operative Management ====
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| ==== Transplantation ====
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| === Primary Prevention ===
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| === Secondary Prevention ===
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| === Cost-Effectiveness of Therapy ===
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| === Future or Investigational Therapies ===
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| ==References==
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| {{Reflist|2}}
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| {{WikiDoc Help Menu}}
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| {{WikiDoc Sources}}
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| [[Category:Disease]]
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| [[Category:Help]]
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