|
|
| (10 intermediate revisions by the same user not shown) |
| Line 1: |
Line 1: |
| __NOTOC__
| |
| {{Neonatal lupus erythrematosus}}
| |
|
| |
|
| {{CMG}}; {{AE}} {{MS}}
| |
|
| |
| Neonatal lupus (NL) is an autoimmune disease of neonates that results from passive transfer of autoantibodies from the mother to the fetus. It occurs in about 1 to 2 percent of babies born to mothers with autoimmune disease, primarily systemic lupus erythematosus (SLE) and Sjögren’s syndrome, and antibodies to SSA/Ro and/or SSB/La.<ref name="pmid20012231">{{cite journal| author=Brucato A, Cimaz R, Caporali R, Ramoni V, Buyon J| title=Pregnancy outcomes in patients with autoimmune diseases and anti-Ro/SSA antibodies. | journal=Clin Rev Allergy Immunol | year= 2011 | volume= 40 | issue= 1 | pages= 27-41 | pmid=20012231 | doi=10.1007/s12016-009-8190-6 | pmc=PMC3558034 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20012231 }} </ref><ref name="pmid19852749">{{cite journal| author=Buyon JP| title=Updates on lupus and pregnancy. | journal=Bull NYU Hosp Jt Dis | year= 2009 | volume= 67 | issue= 3 | pages= 271-5 | pmid=19852749 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19852749}} </ref>. It is characterized by cutaneous, cardiac or rarely both clinical manifestations. The skin manifestations are seen at least in 30% of these patients, in the form of periorbital annular erythematous plaques later spreading to other areas of face, scalp, trunk and extremities which is non-scarring and non-atrophic. This is usually transient lasting for days to months. But, the cardiac manifestations are seen in up to 60% of the patients is mainly in the form of complete congenital heart block (CHB) which is irreversible and
| |
|
| |
| is associate with cardiomyopathy in at least 10% of the cases. Cardiomyopathy is associated with increased morbidity and mortality. Almost all the patients having cardiac lupus require permanent pacemaker. The recurrence rate of neonatal lupus is as much as 25% in the subsequent pregnancies.
| |
|
| |
|
| |
|
| |
| ==References==
| |
| {{Reflist|2}}
| |
| [[Category:Cardiology]]
| |
| [[Category:Up-To-Date]]
| |
| [[Category:Up-To-Date cardiology]]
| |
|
| |
| {{WH}}
| |
| {{WS}}
| |