Ketoacidosis overview: Difference between revisions
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'''Ketoacidosis''' is a type of metabolic [[acidosis]] which is caused by high concentrations of [[ketone bodies]], formed by the [[deamination]] of [[amino acid]]s, and the breakdown of [[fatty acids]]. | '''Ketoacidosis''' is a type of metabolic [[acidosis]] which is caused by high concentrations of [[ketone bodies]], formed by the [[deamination]] of [[amino acid]]s, and the breakdown of [[fatty acids]]. | ||
==Pathophysiology== | ==Pathophysiology== | ||
Ketoacidosis occurs when cells do not have sufficient glucose to meet their metabolic demands. Instead, [[ketone bodies]] are produced for energy via the [[metabolism]] of [[fatty acids]]. Acidity results from the dissociation of the H<sup>+</sup> ion at physiological pH of metabolic ketone bodies such as [[acetoacetate]], and [[Beta-hydroxybutyrate|β-hydroxybutyrate]]. | |||
==Differentiating Ketoacidosis from other Diseases== | ==Differentiating Ketoacidosis from other Diseases== | ||
Ketoacidosis should not be confused with [[ketosis]], which is one of the body's normal processes for the metabolism of body fat. In ketoacidosis, the accumulation of keto acids is so severe that the [[pH]] of the [[blood]] is substantially decreased. | Ketoacidosis should not be confused with [[ketosis]], which is one of the body's normal processes for the metabolism of body fat. In ketoacidosis, the accumulation of keto acids is so severe that the [[pH]] of the [[blood]] is substantially decreased. | ||
Latest revision as of 17:07, 13 February 2013
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Ketoacidosis is a type of metabolic acidosis which is caused by high concentrations of ketone bodies, formed by the deamination of amino acids, and the breakdown of fatty acids.
Pathophysiology
Ketoacidosis occurs when cells do not have sufficient glucose to meet their metabolic demands. Instead, ketone bodies are produced for energy via the metabolism of fatty acids. Acidity results from the dissociation of the H+ ion at physiological pH of metabolic ketone bodies such as acetoacetate, and β-hydroxybutyrate.
Differentiating Ketoacidosis from other Diseases
Ketoacidosis should not be confused with ketosis, which is one of the body's normal processes for the metabolism of body fat. In ketoacidosis, the accumulation of keto acids is so severe that the pH of the blood is substantially decreased.