Zygomycosis diagnostic criteria: Difference between revisions

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==Overview==
==Diagnostic Criteria==
[[Image:PHIL 3960 highres.jpg|thumb|left|200px|This photomicrograph reveals a mature sporangium of a Mucor sp. fungus, which can be responsible for mucormycosis]]
Diagnosis for phycomycosis is through a [[biopsy]] or [[microbiological culture|culture]], although an [[ELISA]] test has been developed for ''Pythium insidiosum'' in animals.<ref name=Hensel>{{cite journal |author=Hensel P, Greene C, Medleau L, Latimer K, Mendoza L |title=Immunotherapy for treatment of multicentric cutaneous pythiosis in a dog |journal=J Am Vet Med Assoc |volume=223 |issue=2 |pages=215-8, 197 |year=2003 |id=PMID 12875449}}</ref> 
As [[swab]]s of tissue or discharge are generally unreliable, the diagnosis of mucormycosis tends to be established by a [[biopsy]] specimen of the involved tissue. Computerised imaging techniques such as [[MRI]]s, [[CT scan]]s and [[X-ray]]s may be useful in the diagnosis of specific areas.<ref name=Emedicine/><ref name=HealthAtoZ>{{cite web|title=Mucormycosis|author=Rebecca J. Frey, PhD|url=http://www.healthatoz.com/healthatoz/Atoz/Atoz/ency/mucormycosis.jsp|publisher=Health A to Z|accessdate=2008-01-20}}</ref> <ref name=Emedicine/>
Diagnosis for basidiobolomycosis is by laboratory culture of the organism, usually from pieces of tissue taken from the patient.  It grows easily on most media, but risks being discarded as irrelevant or being reported as a contaminant because laboratory staff are unfamiliar with it.
Diagnosis is often difficult because basidiobolomycosis is a rare disease and therefore often not recognised.  The lesions often look like tumours rather than infection, so often no sample is sent for microbiology, however, the histopathology is characteristic:  the [[Splendore-Hoeppli phenomenon]] describes the presence of fungal hyphae (which may exist only as ghosts on the slide) surrounded by eosinophilic material.
==References==
{{Reflist|2}}
[[Category:Fungal diseases]]
[[Category:Infectious disease]]
[[Category:Disease]]
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Latest revision as of 15:07, 13 December 2012