Amyotrophic lateral sclerosis classification: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
 
(11 intermediate revisions by 3 users not shown)
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Amyotrophic lateral sclerosis}}
{{Amyotrophic lateral sclerosis}}
{{CMG}}
{{CMG}} {{AE}} {{CP}}{{MMJ}}


==Overview==
==Overview==
ALS is classified into three general groups, '''familial ALS''', '''sporadic ALS''' and '''Guamanian ALS'''.
ALS is classified into two sub-groups: '''Familial ALS''' and '''Sporadic ALS.'''  
==Classification==
==Classification==
* "Familial ALS" accounts for approximately 5%-10% of all ALS cases and is caused by genetic factors.  Of these approximately 10% are linked to a mutation in [[Superoxide dismutase]] (SOD1), a copper/zinc dependant dismutase that is responsible for scavenging free radicals.
* Most of the remaining 90-95% of cases are classified as "sporadic ALS" and have no known hereditary component.
* A third type, called "Guamanian ALS", represents a small cluster of cases concentrated on the Pacific island of Guam.


==Guamanian ALS==
*'''Familial ALS''' accounts for approximately 5%-10% of all ALS cases and is caused due to genetic factors.
There was a high inicidence of this rare form of ALS from the 1940s to the 1960's, and during this thie, the rates of ALS increased by 50 to 100 times of its incidence prior to this time. The incidence of Guamanian ALS has dropped significantly since the 1960's, but during it's peak, it killed more than 10% of the native Chamorro people of Guam.
*'''Sporadic ALS''' accounts for the remaining 90%-95% of ALS with no known cause.  


===Parkinson's and Alzheimers Association===
<br />
Unique to the Guamanian form of ALS, it is associated with the development of cognitive symptoms similar to those seen in Parkinson's disease and Alzheimers dementia. Other forms of ALS tend to only effect the nerves which control the motor function, and do not affect the brain and the mental function.
<ref name="pmid30207670">{{cite journal| author=Hulisz D| title=Amyotrophic lateral sclerosis: disease state overview. | journal=Am J Manag Care | year= 2018 | volume= 24 | issue= 15 Suppl | pages= S320-S326 | pmid=30207670 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30207670  }} </ref>
 
===Non-filtered Drinking Water===
Researchers believe that there are algae and bacteria found in large quantities in areas of Guam, that produce powerful neurotoxins during particular times of the year. Prior to the 1960's, the drinking water was not filtered, and therefore people may have consumed high amounts of these toxins and subsequently developed ALS.
 
===Food Toxins===
People in Guam consumed a lot of flour made with the cycad plant, a plant which resembles the palm tree. This plant has nuts and seeds which do contain a powerful neurotoxin. Another source could be the fact that bats in the area consume a lot of the fruit from the cycad plant, and bat meat was consumed by the native people. The incidence of gaumanian ALS dropped as the native people stopped consuming bat meat.
 
===Genetic Susceptibility===


==References==
==References==

Latest revision as of 11:34, 2 July 2021

Amyotrophic lateral sclerosis Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Amyotrophic lateral sclerosis from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Study of Choice

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Interventions

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Amyotrophic lateral sclerosis classification On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Amyotrophic lateral sclerosis classification

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Amyotrophic lateral sclerosis classification

CDC on Amyotrophic lateral sclerosis classification

Amyotrophic lateral sclerosis classification in the news

Blogs on Amyotrophic lateral sclerosis classification

Directions to Hospitals Treating Psoriasis

Risk calculators and risk factors for Amyotrophic lateral sclerosis classification

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2]Mohamadmostafa Jahansouz M.D.[3]

Overview

ALS is classified into two sub-groups: Familial ALS and Sporadic ALS.

Classification

  • Familial ALS accounts for approximately 5%-10% of all ALS cases and is caused due to genetic factors.
  • Sporadic ALS accounts for the remaining 90%-95% of ALS with no known cause.


[1]

References

  1. ↑ Hulisz D (2018). "Amyotrophic lateral sclerosis: disease state overview". Am J Manag Care. 24 (15 Suppl): S320–S326. PMID 30207670.

Template:WH Template:WS

Retrieved from "https://www.wikidoc.org/index.php?title=Amyotrophic_lateral_sclerosis_classification&oldid=1705721"