WBR0647: Difference between revisions
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{{WBRQuestion | {{WBRQuestion | ||
|QuestionAuthor={{SSK}} (Reviewed by Serge Korjian) | |QuestionAuthor= {{SSK}} (Reviewed by Serge Korjian) | ||
|ExamType=USMLE Step 1 | |ExamType=USMLE Step 1 | ||
|MainCategory=Pathology, Pathophysiology | |MainCategory=Pathology, Pathophysiology |
Latest revision as of 01:19, 28 October 2020
Author | [[PageAuthor::Serge Korjian M.D. (Reviewed by Serge Korjian)]] |
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Exam Type | ExamType::USMLE Step 1 |
Main Category | MainCategory::Pathology, MainCategory::Pathophysiology |
Sub Category | SubCategory::Renal |
Prompt | [[Prompt::A 22-year-old man presents emergency department in panic after he noticed bright red blood in his urine. Upon questioning, the patient reports he had a similar episode two months ago that resolved spontaneously and did not recur until now. The patient explains that the first episode occurred while he was on sick leave for a viral bronchitis. Physical exam is unremarkable. Urinalysis shows >100 RBCs/HPF, with 1+ proteins noted on dipstick. Which of the following glomerular structures is the most likely to be involved in this patient? |
Answer A | AnswerA::A |
Answer A Explanation | AnswerAExp::This refers to the glomerular capillary or endothelial cell. Endothelial involvement is not seen in IgA Nephropathy. It may be seen in lupus nephritis or membranoproliferative glomerulonephritis. |
Answer B | AnswerB::B |
Answer B Explanation | AnswerBExp::Mesangial involvement is characteristic of IgA nephropathy. |
Answer C | AnswerC::C |
Answer C Explanation | AnswerCExp::This refers to the podocyte. It is affected focal segmental glomerulosclerosis, not in IgA nephropathy (at least in early stages) |
Answer D | AnswerD::D |
Answer D Explanation | AnswerDExp::This refers to the glomerular basement membrane which is usually spared in IgA nephropathy. It is involved in the pathogenesis of Alport syndrome and membranoproliferative glomerulonephritis among others. |
Answer E | AnswerE::E |
Answer E Explanation | AnswerEExp::This refers to a podocyte foot process which is usually effaced in minimal change disease and is the cause of the proteinuria. Foot processes are not affected in IgA nephropathy. |
Right Answer | RightAnswer::B |
Explanation | [[Explanation::
|
Approved | Approved::Yes |
Keyword | WBRKeyword::IgA Nephropathy, WBRKeyword::Hematuria, WBRKeyword::Mesangial pattern, WBRKeyword::Mesangium, WBRKeyword::Glomerulonephritis, WBRKeyword::Nephritic syndrome |
Linked Question | Linked:: |
Order in Linked Questions | LinkedOrder:: |