Hepatitis B risk factors: Difference between revisions

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==Risk Factors==
==Risk Factors==
Individuals who are at increased risk of [[hepatitis B infection]] include:<ref name=WHO-Hepatitis-B_2003>World Health Organization. Department of Cummunicable Disease Surveillance and Response http://apps.who.int/iris/bitstream/10665/67746/1/WHO_CDS_CSR_LYO_2002.2_HEPATITIS_B.pdf</ref><ref name=USPTF-Hepatitis-B>US. Preventive Services Task Force. Screening for Hepatitis B infection. (2014) https://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummaryFinal/hepatitis-b-virus-infection-screening-2014?ds=1&s=hepatitis%20b Accessed on October 4th, 2016</ref>  
Individuals who are at increased risk of [[hepatitis B infection]] include:<ref name="WHO-Hepatitis-B_2003">World Health Organization. Department of Cummunicable Disease Surveillance and Response http://apps.who.int/iris/bitstream/10665/67746/1/WHO_CDS_CSR_LYO_2002.2_HEPATITIS_B.pdf</ref><ref name="USPTF-Hepatitis-B">US. Preventive Services Task Force. Screening for Hepatitis B infection. (2014) https://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummaryFinal/hepatitis-b-virus-infection-screening-2014?ds=1&s=hepatitis%20b Accessed on October 4th, 2016</ref>  
* Infants born to [[infected]] mothers
* Infants born to [[infected]] mothers
* Young children in day-care or residential settings with other children in [[endemic]] areas
* Young children in day-care or residential settings with other children in [[endemic]] areas
* Sexual/household contacts of [[infected]] persons
* Sexual/household contacts of [[infected]] persons
*ƒ Patients and employees in [[hemodialysis]] centers
*Patients and employees in [[hemodialysis]] centers
* Injection drug users sharing unsterilized needles
* Injection drug users sharing unsterilized needles
* People sharing unsterilized medical or dental equipment
* People sharing unsterilized medical or dental equipment
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* Travel to areas where hepatitis B is common
* Travel to areas where hepatitis B is common


Frequent and routine exposure to [[blood]] or [[serum]] is the common denominator of healthcare occupational exposure.<ref name=WHO>{{cite web | title = Hepatitis B | url = http://www.who.int/csr/disease/hepatitis/HepatitisB_whocdscsrlyo2002_2.pdf }}</ref>
Frequent and routine exposure to [[blood]] or [[serum]] is the common denominator of healthcare occupational exposure.<ref name="WHO">{{cite web | title = Hepatitis B | url = http://www.who.int/csr/disease/hepatitis/HepatitisB_whocdscsrlyo2002_2.pdf }}</ref>
   
   
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Hepatitis B virus presents in all patients with infection. Patients who are either HBsAg-positive or anti HBc-positive are at the risk of hepatitis B reactivation.
Hepatitis B virus presents in all patients with infection. Patients who are either HBsAg-positive or anti HBc-positive are at the risk of hepatitis B reactivation.


Patients are at risk for HBV reactivation in the following conditions:<ref name="pmid23111095">{{cite journal| author=Lee YH, Bae SC, Song GG| title=Hepatitis B virus (HBV) reactivation in rheumatic patients with hepatitis core antigen (HBV occult carriers) undergoing anti-tumor necrosis factor therapy. | journal=Clin Exp Rheumatol | year= 2013 | volume= 31 | issue= 1 | pages= 118-21 | pmid=23111095 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23111095  }} </ref><ref name="pmid22392695">{{cite journal| author=Kim PS, Ho GY, Prete PE, Furst DE| title=Safety and efficacy of abatacept in eight rheumatoid arthritis patients with chronic hepatitis B. | journal=Arthritis Care Res (Hoboken) | year= 2012 | volume= 64 | issue= 8 | pages= 1265-8 | pmid=22392695 | doi=10.1002/acr.21654 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22392695  }} </ref><ref name="pmid6105519">{{cite journal| author=Sagnelli E, Manzillo G, Maio G, Pasquale G, Felaco FM, Filippini P et al.| title=Serum levels of hepatitis B surface and core antigens during immunosuppressive treatment of HBsAg-positive chronic active hepatitis. | journal=Lancet | year= 1980 | volume= 2 | issue= 8191 | pages= 395-7 | pmid=6105519 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6105519  }} </ref><ref name="pmid3884951">{{cite journal| author=Nair PV, Tong MJ, Stevenson D, Roskamp D, Boone C| title=Effects of short-term, high-dose prednisone treatment of patients with HBsAg-positive chronic active hepatitis. | journal=Liver | year= 1985 | volume= 5 | issue= 1 | pages= 8-12 | pmid=3884951 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3884951  }} </ref><ref name=> Europian Medicines Agency. reviews direct-acting antivirals for hepatitis C. (2016) http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Direct-acting_antivirals_for_hepatitis_C_20/Procedure_started/WC500203479.pdf </ref><ref name=FDA>
Patients are at risk for HBV reactivation in the following conditions:<ref name="pmid23111095">{{cite journal| author=Lee YH, Bae SC, Song GG| title=Hepatitis B virus (HBV) reactivation in rheumatic patients with hepatitis core antigen (HBV occult carriers) undergoing anti-tumor necrosis factor therapy. | journal=Clin Exp Rheumatol | year= 2013 | volume= 31 | issue= 1 | pages= 118-21 | pmid=23111095 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23111095  }} </ref><ref name="pmid22392695">{{cite journal| author=Kim PS, Ho GY, Prete PE, Furst DE| title=Safety and efficacy of abatacept in eight rheumatoid arthritis patients with chronic hepatitis B. | journal=Arthritis Care Res (Hoboken) | year= 2012 | volume= 64 | issue= 8 | pages= 1265-8 | pmid=22392695 | doi=10.1002/acr.21654 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22392695  }} </ref><ref name="pmid6105519">{{cite journal| author=Sagnelli E, Manzillo G, Maio G, Pasquale G, Felaco FM, Filippini P et al.| title=Serum levels of hepatitis B surface and core antigens during immunosuppressive treatment of HBsAg-positive chronic active hepatitis. | journal=Lancet | year= 1980 | volume= 2 | issue= 8191 | pages= 395-7 | pmid=6105519 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6105519  }} </ref><ref name="pmid3884951">{{cite journal| author=Nair PV, Tong MJ, Stevenson D, Roskamp D, Boone C| title=Effects of short-term, high-dose prednisone treatment of patients with HBsAg-positive chronic active hepatitis. | journal=Liver | year= 1985 | volume= 5 | issue= 1 | pages= 8-12 | pmid=3884951 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3884951  }} </ref><ref>Europian Medicines Agency. reviews direct-acting antivirals for hepatitis C. (2016) http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Direct-acting_antivirals_for_hepatitis_C_20/Procedure_started/WC500203479.pdf </ref><ref name="FDA">U.S Food and Drug Adminestration. Drug Safety Communication: FDA warns about the risk of hepatitis B reactivating in some patients treated with direct-acting antivirals for hepatitis C http://www.fda.gov/downloads/Drugs/DrugSafety/UCM523499.pdf</ref>
U.S Food and Drug Adminestration. Drug Safety Communication: FDA warns about the risk of hepatitis B reactivating in some patients treated with direct-acting antivirals for hepatitis C http://www.fda.gov/downloads/Drugs/DrugSafety/UCM523499.pdf</ref>
*Receive immunosuppressive therapy
*Receive immunosuppressive therapy
**[[Chemotherapy agents]]
**[[Chemotherapy agents]]
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{{Reflist|2}}
{{Reflist|2}}


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Latest revision as of 22:05, 29 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2], Sara Mehrsefat, M.D. [3]

Overview

Common risk factors in the development of HBV infection include sexual contact with infected individuals, sharing a household with a carrier, intravenous drug use, travel to endemic regions, perinatal transmission from infected mothers to infants, and certain occupations.

Risk Factors

Individuals who are at increased risk of hepatitis B infection include:[1][2]

  • Infants born to infected mothers
  • Young children in day-care or residential settings with other children in endemic areas
  • Sexual/household contacts of infected persons
  • Patients and employees in hemodialysis centers
  • Injection drug users sharing unsterilized needles
  • People sharing unsterilized medical or dental equipment
  • People providing or receiving acupuncture and/or tattooing with unsterilized medical devices
  • Persons living in regions or travelling to regions with endemic hepatitis B
    • Country of origin is the major risk factor for HBV infection (prevalence threshold of 2% or greater to define countries with high risk for HBV infection)
  • Sexually active heterosexuals
  • Lack of vaccination in infancy
  • Men who have sex with men
  • Hemophilia patients
  • Travel to areas where hepatitis B is common

Frequent and routine exposure to blood or serum is the common denominator of healthcare occupational exposure.[3]

Source: https://www.cdc.gov/
Source: https://www.cdc.gov/

Hepatitis B Reactivation

Hepatitis B virus presents in all patients with infection. Patients who are either HBsAg-positive or anti HBc-positive are at the risk of hepatitis B reactivation.

Patients are at risk for HBV reactivation in the following conditions:[4][5][6][7][8][9]

References

  1. World Health Organization. Department of Cummunicable Disease Surveillance and Response http://apps.who.int/iris/bitstream/10665/67746/1/WHO_CDS_CSR_LYO_2002.2_HEPATITIS_B.pdf
  2. US. Preventive Services Task Force. Screening for Hepatitis B infection. (2014) https://www.uspreventiveservicestaskforce.org/Page/Document/UpdateSummaryFinal/hepatitis-b-virus-infection-screening-2014?ds=1&s=hepatitis%20b Accessed on October 4th, 2016
  3. "Hepatitis B" (PDF).
  4. Lee YH, Bae SC, Song GG (2013). "Hepatitis B virus (HBV) reactivation in rheumatic patients with hepatitis core antigen (HBV occult carriers) undergoing anti-tumor necrosis factor therapy". Clin Exp Rheumatol. 31 (1): 118–21. PMID 23111095.
  5. Kim PS, Ho GY, Prete PE, Furst DE (2012). "Safety and efficacy of abatacept in eight rheumatoid arthritis patients with chronic hepatitis B." Arthritis Care Res (Hoboken). 64 (8): 1265–8. doi:10.1002/acr.21654. PMID 22392695.
  6. Sagnelli E, Manzillo G, Maio G, Pasquale G, Felaco FM, Filippini P; et al. (1980). "Serum levels of hepatitis B surface and core antigens during immunosuppressive treatment of HBsAg-positive chronic active hepatitis". Lancet. 2 (8191): 395–7. PMID 6105519.
  7. Nair PV, Tong MJ, Stevenson D, Roskamp D, Boone C (1985). "Effects of short-term, high-dose prednisone treatment of patients with HBsAg-positive chronic active hepatitis". Liver. 5 (1): 8–12. PMID 3884951.
  8. Europian Medicines Agency. reviews direct-acting antivirals for hepatitis C. (2016) http://www.ema.europa.eu/docs/en_GB/document_library/Referrals_document/Direct-acting_antivirals_for_hepatitis_C_20/Procedure_started/WC500203479.pdf
  9. U.S Food and Drug Adminestration. Drug Safety Communication: FDA warns about the risk of hepatitis B reactivating in some patients treated with direct-acting antivirals for hepatitis C http://www.fda.gov/downloads/Drugs/DrugSafety/UCM523499.pdf

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