Adult T-cell leukemia laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Adult T-cell leukemia}} | {{Adult T-cell leukemia}} | ||
{{CMG}} | {{CMG}}; {{AE}} {{HL}}; {{GRR}} {{Nat}} | ||
==Overview== | ==Overview== | ||
Laboratory findings consistent with the diagnosis of adult T-cell leukemia include abnormal [[anemia]], [[thrombocytopenia]], and elevated [[lymphocyte]] count. [[Hypercalcemia]] is a key feature among patients with adult T-cell leukemia. | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
* [[ | The following laboratory abnormalities may be observed in patients suffering from adult T-cell leukemia:<ref name="pmid18042693">Matutes E (2007) [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=18042693 Adult T-cell leukaemia/lymphoma.] ''J Clin Pathol'' 60 (12):1373-7. [http://dx.doi.org/10.1136/jcp.2007.052456 DOI:10.1136/jcp.2007.052456] PMID: [http://pubmed.gov/18042693 18042693]</ref><ref name="pmid1751370">{{cite journal| author=Shimoyama M| title=Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87). | journal=Br J Haematol | year= 1991 | volume= 79 | issue= 3 | pages= 428-37 | pmid=1751370 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1751370 }} </ref><ref name="pmid20425378">{{cite journal| author=Mahieux R, Gessain A| title=Adult T-cell leukemia/lymphoma and HTLV-1. | journal=Curr Hematol Malig Rep | year= 2007 | volume= 2 | issue= 4 | pages= 257-64 | pmid=20425378 | doi=10.1007/s11899-007-0035-x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20425378 }} </ref> | ||
* [[Hypercalcemia]] | |||
* [[ | ===Complete Blood Count=== | ||
* [[ | * [[Anemia]] | ||
* [[ | * [[Thrombocytopenia]] | ||
* Elevated [[lymphocyte]] count | |||
===Basic Metabolic Panel=== | |||
* [[Hypercalcemia]] | |||
===Peripheral Smear=== | |||
* Characteristic leukemia cells with sharp [[nuclear]] indentations and a prominent [[nucleoli]] | |||
* "Cloverleaf" or "flower" cells | |||
===Antibody Titres=== | |||
* Detects [[antibodies]] present against [[HTLV]] [[antigen]]s | |||
===Immunohistochemistry=== | |||
* Adult T-cell leukemia cells are typically [[CD2]], [[CD4]], [[CD5]], and [[CD8]] positive. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Medicine]] | |||
[[Category: | |||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Immunology]] | |||
[[Category:Infectious disease]] | |||
[[Category:Oncology]] | |||
[[Category:Up-To-Date]] | |||
Latest revision as of 20:18, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]; Grammar Reviewer: Natalie Harpenau, B.S.[3]
Overview
Laboratory findings consistent with the diagnosis of adult T-cell leukemia include abnormal anemia, thrombocytopenia, and elevated lymphocyte count. Hypercalcemia is a key feature among patients with adult T-cell leukemia.
Laboratory Findings
The following laboratory abnormalities may be observed in patients suffering from adult T-cell leukemia:[1][2][3]
Complete Blood Count
- Anemia
- Thrombocytopenia
- Elevated lymphocyte count
Basic Metabolic Panel
Peripheral Smear
- Characteristic leukemia cells with sharp nuclear indentations and a prominent nucleoli
- "Cloverleaf" or "flower" cells
Antibody Titres
- Detects antibodies present against HTLV antigens
Immunohistochemistry
References
- ↑ Matutes E (2007) Adult T-cell leukaemia/lymphoma. J Clin Pathol 60 (12):1373-7. DOI:10.1136/jcp.2007.052456 PMID: 18042693
- ↑ Shimoyama M (1991). "Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87)". Br J Haematol. 79 (3): 428–37. PMID 1751370.
- ↑ Mahieux R, Gessain A (2007). "Adult T-cell leukemia/lymphoma and HTLV-1". Curr Hematol Malig Rep. 2 (4): 257–64. doi:10.1007/s11899-007-0035-x. PMID 20425378.