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'''HIV Tat-specific factor 1''' is a [[protein]] that in humans is encoded by the ''HTATSF1'' [[gene]].<ref name="pmid8849451">{{cite journal |vauthors=Zhou Q, Sharp PA | title = Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat | journal = Science | volume = 274 | issue = 5287 | pages = 605–10 |date=Nov 1996 | pmid = 8849451 | pmc =  | doi =10.1126/science.274.5287.605  | bibcode =1996Sci...274..605Z }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: HTATSF1 HIV-1 Tat specific factor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27336| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_HTATSF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dit.
| PDB = {{PDB2|2dit}}
| Name = HIV-1 Tat specific factor 1
| HGNCid = 5276
| Symbol = HTATSF1
| AltSymbols =; TAT-SF1; dJ196E23.2
| OMIM = 300346
| ECnumber = 
| Homologene = 40950
| MGIid = 1919709
| GeneAtlas_image1 = PBB_GE_HTATSF1_202602_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_HTATSF1_202601_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003702 |text = RNA polymerase II transcription factor activity}} {{GNF_GO|id=GO:0003711 |text = transcription elongation regulator activity}} {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0019079 |text = viral genome replication}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27336
    | Hs_Ensembl = ENSG00000102241
    | Hs_RefseqProtein = NP_055315
    | Hs_RefseqmRNA = NM_014500
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 135406904
    | Hs_GenLoc_end = 135422171
    | Hs_Uniprot = O43719
    | Mm_EntrezGene = 72459
    | Mm_Ensembl = ENSMUSG00000067873
    | Mm_RefseqmRNA = NM_028242
    | Mm_RefseqProtein = NP_082518
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 53400399
    | Mm_GenLoc_end = 53413967
    | Mm_Uniprot = Q8BGC0
  }}
}}
'''HIV-1 Tat specific factor 1''', also known as '''HTATSF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: HTATSF1 HIV-1 Tat specific factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27336| accessdate = }}</ref>
 
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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: HTATSF1 HIV-1 Tat specific factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27336| accessdate = }}</ref>
| summary_text = Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication.[supplied by OMIM]<ref name="entrez"/>
}}
}}
==Interactions==
HTATSF1 has been shown to [[Protein-protein interaction|interact]] with [[SUPT5H]]<ref name=pmid10454543>{{cite journal |last=Kim |first=J B |authorlink= |author2=Yamaguchi Y |author3=Wada T |author4=Handa H |author5=Sharp P A  |date=Sep 1999 |title=Tat-SF1 protein associates with RAP30 and human SPT5 proteins |journal=Mol. Cell. Biol. |volume=19 |issue=9 |pages=5960–8 | issn = 0270-7306| pmid = 10454543 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=84462 | doi=10.1128/mcb.19.9.5960}}</ref> and [[GTF2F2]].<ref name=pmid10454543/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Zhou Q, Sharp PA |title=Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. |journal=Science |volume=274 |issue= 5287 |pages= 605-10 |year= 1996 |pmid= 8849451 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Zhou Q, Chen D, Pierstorff E, Luo K |title=Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages |journal=EMBO J. |volume=17 |issue= 13 |pages= 3681–91 |year= 1998 |pmid= 9649438 |doi= 10.1093/emboj/17.13.3681 | pmc=1170704 }}
*{{cite journal | author=Zhou Q, Chen D, Pierstorff E, Luo K |title=Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages. |journal=EMBO J. |volume=17 |issue= 13 |pages= 3681-91 |year= 1998 |pmid= 9649438 |doi= 10.1093/emboj/17.13.3681 }}
*{{cite journal   |vauthors=Yan D, Perriman R, Igel H, etal |title=CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5000–9 |year= 1998 |pmid= 9710584 |doi= | pmc=109085  }}
*{{cite journal  | author=Yan D, Perriman R, Igel H, ''et al.'' |title=CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5000-9 |year= 1998 |pmid= 9710584 |doi=  }}
*{{cite journal  |vauthors=Li XY, Green MR |title=The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor |journal=Genes Dev. |volume=12 |issue= 19 |pages= 2992–6 |year= 1998 |pmid= 9765201 |doi=10.1101/gad.12.19.2992  | pmc=317190 }}
*{{cite journal  | author=Li XY, Green MR |title=The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor. |journal=Genes Dev. |volume=12 |issue= 19 |pages= 2992-6 |year= 1998 |pmid= 9765201 |doi= }}
*{{cite journal  |vauthors=Parada CA, Roeder RG |title=A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription |journal=EMBO J. |volume=18 |issue= 13 |pages= 3688–701 |year= 1999 |pmid= 10393184 |doi= 10.1093/emboj/18.13.3688  | pmc=1171446 }}
*{{cite journal | author=Parada CA, Roeder RG |title=A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription. |journal=EMBO J. |volume=18 |issue= 13 |pages= 3688-701 |year= 1999 |pmid= 10393184 |doi= 10.1093/emboj/18.13.3688 }}
*{{cite journal   |vauthors=Kim JB, Yamaguchi Y, Wada T, etal |title=Tat-SF1 protein associates with RAP30 and human SPT5 proteins |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 5960–8 |year= 1999 |pmid= 10454543 |doi= 10.1128/mcb.19.9.5960| pmc=84462  }}
*{{cite journal  | author=Kim JB, Yamaguchi Y, Wada T, ''et al.'' |title=Tat-SF1 protein associates with RAP30 and human SPT5 proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 5960-8 |year= 1999 |pmid= 10454543 |doi= }}
*{{cite journal  |vauthors=Fong YW, Zhou Q |title=Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter |journal=Mol. Cell. Biol. |volume=20 |issue= 16 |pages= 5897–907 |year= 2000 |pmid= 10913173 |doi=10.1128/MCB.20.16.5897-5907.2000  | pmc=86067  }}
*{{cite journal | author=Fong YW, Zhou Q |title=Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter. |journal=Mol. Cell. Biol. |volume=20 |issue= 16 |pages= 5897-907 |year= 2000 |pmid= 10913173 |doi= }}
*{{cite journal   |vauthors=Suñé C, Goldstrohm AC, Peng J, etal |title=An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation |journal=Virology |volume=274 |issue= 2 |pages= 356–66 |year= 2000 |pmid= 10964778 |doi= 10.1006/viro.2000.0480 }}
*{{cite journal  | author=Suñé C, Goldstrohm AC, Peng J, ''et al.'' |title=An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation. |journal=Virology |volume=274 |issue= 2 |pages= 356-66 |year= 2000 |pmid= 10964778 |doi= 10.1006/viro.2000.0480 }}
*{{cite journal  |vauthors=Simmons A, Aluvihare V, McMichael A |title=Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators |journal=Immunity |volume=14 |issue= 6 |pages= 763–77 |year= 2001 |pmid= 11420046 |doi=10.1016/S1074-7613(01)00158-3  }}
*{{cite journal  | author=Simmons A, Aluvihare V, McMichael A |title=Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. |journal=Immunity |volume=14 |issue= 6 |pages= 763-77 |year= 2001 |pmid= 11420046 |doi= }}
*{{cite journal  |vauthors=Fong YW, Zhou Q |title=Stimulatory effect of splicing factors on transcriptional elongation |journal=Nature |volume=414 |issue= 6866 |pages= 929–33 |year= 2002 |pmid= 11780068 |doi= 10.1038/414929a }}
*{{cite journal | author=Fong YW, Zhou Q |title=Stimulatory effect of splicing factors on transcriptional elongation. |journal=Nature |volume=414 |issue= 6866 |pages= 929-33 |year= 2002 |pmid= 11780068 |doi= 10.1038/414929a }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Zhou BY, He JJ |title=Proliferation inhibition of astrocytes, neurons, and non-glial cells by intracellularly expressed human immunodeficiency virus type 1 (HIV-1) Tat protein |journal=Neurosci. Lett. |volume=359 |issue= 3 |pages= 155–8 |year= 2004 |pmid= 15050687 |doi= 10.1016/j.neulet.2004.02.012 }}
*{{cite journal | author=Zhou BY, He JJ |title=Proliferation inhibition of astrocytes, neurons, and non-glial cells by intracellularly expressed human immunodeficiency virus type 1 (HIV-1) Tat protein. |journal=Neurosci. Lett. |volume=359 |issue= 3 |pages= 155-8 |year= 2004 |pmid= 15050687 |doi= 10.1016/j.neulet.2004.02.012 }}
*{{cite journal   |vauthors=Ballif BA, Villén J, Beausoleil SA, etal |title=Phosphoproteomic analysis of the developing mouse brain |journal=Mol. Cell. Proteomics |volume=3 |issue= 11 |pages= 1093–101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal  | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
*{{cite journal  |vauthors=Smith MJ, Kulkarni S, Pawson T |title=FF domains of CA150 bind transcription and splicing factors through multiple weak interactions |journal=Mol. Cell. Biol. |volume=24 |issue= 21 |pages= 9274–85 |year= 2004 |pmid= 15485897 |doi= 10.1128/MCB.24.21.9274-9285.2004  | pmc=522232 }}
*{{cite journal | author=Smith MJ, Kulkarni S, Pawson T |title=FF domains of CA150 bind transcription and splicing factors through multiple weak interactions. |journal=Mol. Cell. Biol. |volume=24 |issue= 21 |pages= 9274-85 |year= 2004 |pmid= 15485897 |doi= 10.1128/MCB.24.21.9274-9285.2004 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Zhou M, Deng L, Lacoste V, etal |title=Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription |journal=J. Virol. |volume=78 |issue= 24 |pages= 13522–33 |year= 2004 |pmid= 15564463 |doi= 10.1128/JVI.78.24.13522-13533.2004  | pmc=533906 }}
*{{cite journal | author=Zhou M, Deng L, Lacoste V, ''et al.'' |title=Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription. |journal=J. Virol. |volume=78 |issue= 24 |pages= 13522-33 |year= 2004 |pmid= 15564463 |doi= 10.1128/JVI.78.24.13522-13533.2004 }}
*{{cite journal   |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440  | pmc=2665286 |bibcode=2005Natur.434..325R }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal   |vauthors=Missé D, Gajardo J, Oblet C, etal |title=Soluble HIV-1 gp120 enhances HIV-1 replication in non-dividing CD4+ T cells, mediated via cell signaling and Tat cofactor overexpression |journal=AIDS |volume=19 |issue= 9 |pages= 897–905 |year= 2005 |pmid= 15905670 |doi=10.1097/01.aids.0000171403.07995.92 }}
*{{cite journal  | author=Missé D, Gajardo J, Oblet C, ''et al.'' |title=Soluble HIV-1 gp120 enhances HIV-1 replication in non-dividing CD4+ T cells, mediated via cell signaling and Tat cofactor overexpression. |journal=AIDS |volume=19 |issue= 9 |pages= 897-905 |year= 2005 |pmid= 15905670 |doi= }}
}}
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{{PDB Gallery|geneid=27336}}
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Latest revision as of 22:41, 5 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

HIV Tat-specific factor 1 is a protein that in humans is encoded by the HTATSF1 gene.[1][2]

Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication.[supplied by OMIM][2]

Interactions

HTATSF1 has been shown to interact with SUPT5H[3] and GTF2F2.[3]

References

  1. ↑ Zhou Q, Sharp PA (Nov 1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451.
  2. ↑ 2.0 2.1 "Entrez Gene: HTATSF1 HIV-1 Tat specific factor 1".
  3. ↑ 3.0 3.1 Kim, J B; Yamaguchi Y; Wada T; Handa H; Sharp P A (Sep 1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins". Mol. Cell. Biol. 19 (9): 5960–8. doi:10.1128/mcb.19.9.5960. ISSN 0270-7306. PMC 84462. PMID 10454543.

Further reading



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