SFRS3: Difference between revisions

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{{Infobox_gene}}
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'''Splicing factor, arginine/serine-rich 3''' is a [[protein]] that in humans is encoded by the ''SFRS3'' [[gene]].<ref name="pmid1577277">{{cite journal |author1=Zahler AM |author2=Lane WS |author3=Stolk JA |author4=Roth MB | title = SR proteins: a conserved family of pre-mRNA splicing factors | journal = Genes Dev | volume = 6 | issue = 5 | pages = 837–47 |date=Jun 1992 | pmid = 1577277 | pmc =  | doi =10.1101/gad.6.5.837 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SFRS3 splicing factor, arginine/serine-rich 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6428| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Splicing factor, arginine/serine-rich 3
| HGNCid = 10785
| Symbol = SFRS3
| AltSymbols =; SRp20
| OMIM = 603364
| ECnumber = 
| Homologene = 55708
| MGIid = 98285
| GeneAtlas_image1 = PBB_GE_SFRS3_202899_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SFRS3_208673_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SFRS3_208672_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6428
    | Hs_Ensembl = ENSG00000112081
    | Hs_RefseqProtein = NP_003008
    | Hs_RefseqmRNA = NM_003017
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 36670123
    | Hs_GenLoc_end = 36679187
    | Hs_Uniprot = P84103
    | Mm_EntrezGene = 20383
    | Mm_Ensembl = ENSMUSG00000071172
    | Mm_RefseqmRNA = XM_991475
    | Mm_RefseqProtein = XP_996569
    | Mm_GenLoc_db =  
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 28760340
    | Mm_GenLoc_end = 28771033
    | Mm_Uniprot = Q3U781
  }}
}}
'''Splicing factor, arginine/serine-rich 3''', also known as '''SFRS3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SFRS3 splicing factor, arginine/serine-rich 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6428| accessdate = }}</ref>


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==Browser View==
[http://genome.ucsc.edu/cgi-bin/hgTracks?db=hg18&knownGene=pack&hgFind.matches=uc003omj.1, UCSC Genome Browser View]
[http://genome.ucsc.edu/cgi-bin/hgGene?hgg_gene=uc003omj.1&hgg_prot=P84103&hgg_type=knownGene&db=hg18, UCSC Gene details page]
==Interactions==
SFRS3 has been shown to [[Protein-protein interaction|interact]] with [[RBM7]].<ref name=pmid12634307>{{cite journal |last=Guo |first=Taylor B |authorlink= |author2=Boros Laszlo G |author3=Chan Kam C |author4=Hikim Amiya P Sinha |author5=Hudson Alan P |author6=Swerdloff Ronald S |author7=Mitchell Aaron P |author8=Salameh Wael A  |year=2003|title=Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors |journal=J. Androl. |volume=24 |issue=2 |pages=204–14 |publisher= |location = United States| issn = 0196-3635| pmid = 12634307 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = | doi=10.1002/j.1939-4640.2003.tb02664.x}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Zahler AM, Lane WS, Stolk JA, Roth MB |title=SR proteins: a conserved family of pre-mRNA splicing factors. |journal=Genes Dev. |volume=6 |issue= 5 |pages= 837-47 |year= 1992 |pmid= 1577277 |doi= }}
*{{cite journal  |author1=Ayane M |author2=Preuss U |author3=Köhler G |author4=Nielsen PJ |title=A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. |journal=Nucleic Acids Res. |volume=19 |issue= 6 |pages= 1273–8 |year= 1991 |pmid= 2030943 |doi=10.1093/nar/19.6.1273 | pmc=333853 }}
*{{cite journal  | author=Ayane M, Preuss U, Köhler G, Nielsen PJ |title=A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. |journal=Nucleic Acids Res. |volume=19 |issue= 6 |pages= 1273-8 |year= 1991 |pmid= 2030943 |doi=  }}
*{{cite journal  |author1=Gui JF |author2=Lane WS |author3=Fu XD |title=A serine kinase regulates intracellular localization of splicing factors in the cell cycle. |journal=Nature |volume=369 |issue= 6482 |pages= 678–82 |year= 1994 |pmid= 8208298 |doi= 10.1038/369678a0 |bibcode=1994Natur.369..678G }}
*{{cite journal  | author=Gui JF, Lane WS, Fu XD |title=A serine kinase regulates intracellular localization of splicing factors in the cell cycle. |journal=Nature |volume=369 |issue= 6482 |pages= 678-82 |year= 1994 |pmid= 8208298 |doi= 10.1038/369678a0 }}
*{{cite journal  |author1=Cáceres JF |author2=Screaton GR |author3=Krainer AR |title=A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. |journal=Genes Dev. |volume=12 |issue= 1 |pages= 55–66 |year= 1998 |pmid= 9420331 |doi=10.1101/gad.12.1.55  | pmc=316398  }}
*{{cite journal  | author=Cáceres JF, Screaton GR, Krainer AR |title=A specific subset of SR proteins shuttles continuously between the nucleus and the cytoplasm. |journal=Genes Dev. |volume=12 |issue= 1 |pages= 55-66 |year= 1998 |pmid= 9420331 |doi= }}
*{{cite journal  |author1=Zhang WJ |author2=Wu JY |title=Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 676–84 |year= 1998 |pmid= 9447963 |doi= | pmc=108778 }}
*{{cite journal  | author=Zhang WJ, Wu JY |title=Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing. |journal=Mol. Cell. Biol. |volume=18 |issue= 2 |pages= 676-84 |year= 1998 |pmid= 9447963 |doi=  }}
*{{cite journal   |vauthors=Tripodis N, Mason R, Humphray SJ, etal |title=Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. |journal=Genome Res. |volume=8 |issue= 6 |pages= 631–43 |year= 1999 |pmid= 9647638 |doi=  10.1101/gr.8.6.631| pmc=310739  }}
*{{cite journal | author=Tripodis N, Mason R, Humphray SJ, ''et al.'' |title=Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex. |journal=Genome Res. |volume=8 |issue= 6 |pages= 631-43 |year= 1999 |pmid= 9647638 |doi=  }}
*{{cite journal   |vauthors=Papoutsopoulou S, Nikolakaki E, Chalepakis G, etal |title=SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1. |journal=Nucleic Acids Res. |volume=27 |issue= 14 |pages= 2972–80 |year= 1999 |pmid= 10390541 |doi=10.1093/nar/27.14.2972  | pmc=148514 }}
*{{cite journal | author=Papoutsopoulou S, Nikolakaki E, Chalepakis G, ''et al.'' |title=SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1. |journal=Nucleic Acids Res. |volume=27 |issue= 14 |pages= 2972-80 |year= 1999 |pmid= 10390541 |doi=  }}
*{{cite journal  |author1=Barnard DC |author2=Patton JG |title=Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 9 |pages= 3049–57 |year= 2000 |pmid= 10757789 |doi=10.1128/MCB.20.9.3049-3057.2000  | pmc=85584 }}
*{{cite journal  | author=Barnard DC, Patton JG |title=Identification and characterization of a novel serine-arginine-rich splicing regulatory protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 9 |pages= 3049-57 |year= 2000 |pmid= 10757789 |doi=  }}
*{{cite journal   |vauthors=Shnyreva M, Schullery DS, Suzuki H, etal |title=Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15498–503 |year= 2000 |pmid= 10809782 |doi=10.1074/jbc.275.20.15498 }}
*{{cite journal | author=Shnyreva M, Schullery DS, Suzuki H, ''et al.'' |title=Interaction of two multifunctional proteins. Heterogeneous nuclear ribonucleoprotein K and Y-box-binding protein. |journal=J. Biol. Chem. |volume=275 |issue= 20 |pages= 15498-503 |year= 2000 |pmid= 10809782 |doi=  }}
*{{cite journal   |vauthors=Elliott DJ, Bourgeois CF, Klink A, etal |title=A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 11 |pages= 5717–22 |year= 2000 |pmid= 10823932 |doi=10.1073/pnas.97.11.5717  | pmc=18499  |bibcode=2000PNAS...97.5717E }}
*{{cite journal | author=Elliott DJ, Bourgeois CF, Klink A, ''et al.'' |title=A mammalian germ cell-specific RNA-binding protein interacts with ubiquitously expressed proteins involved in splice site selection. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 11 |pages= 5717-22 |year= 2000 |pmid= 10823932 |doi= }}
*{{cite journal  |author1=Huang Y |author2=Steitz JA |title=Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA. |journal=Mol. Cell |volume=7 |issue= 4 |pages= 899–905 |year= 2001 |pmid= 11336712 |doi=10.1016/S1097-2765(01)00233-7 }}
*{{cite journal  | author=Huang Y, Steitz JA |title=Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA. |journal=Mol. Cell |volume=7 |issue= 4 |pages= 899-905 |year= 2001 |pmid= 11336712 |doi=  }}
*{{cite journal   |vauthors=Andersen JS, Lyon CE, Fox AH, etal |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 }}
*{{cite journal | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal  |author1=Barnard DC |author2=Li J |author3=Peng R |author4=Patton JG |title=Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins. |journal=RNA |volume=8 |issue= 4 |pages= 526–33 |year= 2002 |pmid= 11991645 |doi=10.1017/S1355838202029928  | pmc=1370273 }}
*{{cite journal  | author=Barnard DC, Li J, Peng R, Patton JG |title=Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins. |journal=RNA |volume=8 |issue= 4 |pages= 526-33 |year= 2002 |pmid= 11991645 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Guo TB, Boros LG, Chan KC, etal |title=Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors. |journal=J. Androl. |volume=24 |issue= 2 |pages= 204–14 |year= 2003 |pmid= 12634307 |doi=  10.1002/j.1939-4640.2003.tb02664.x}}
*{{cite journal | author=Guo TB, Boros LG, Chan KC, ''et al.'' |title=Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors. |journal=J. Androl. |volume=24 |issue= 2 |pages= 204-14 |year= 2003 |pmid= 12634307 |doi=  }}
*{{cite journal   |vauthors=Tai HH, Geisterfer M, Bell JC, etal |title=CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 1 |pages= 170–6 |year= 2003 |pmid= 12890497 |doi=10.1016/S0006-291X(03)01354-8 }}
*{{cite journal | author=Tai HH, Geisterfer M, Bell JC, ''et al.'' |title=CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins. |journal=Biochem. Biophys. Res. Commun. |volume=308 |issue= 1 |pages= 170-6 |year= 2003 |pmid= 12890497 |doi=  }}
*{{cite journal   |vauthors=Li J, Hawkins IC, Harvey CD, etal |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437–47 |year= 2003 |pmid= 14559993 |doi=10.1128/MCB.23.21.7437-7447.2003  | pmc=207616 }}
*{{cite journal | author=Li J, Hawkins IC, Harvey CD, ''et al.'' |title=Regulation of alternative splicing by SRrp86 and its interacting proteins. |journal=Mol. Cell. Biol. |volume=23 |issue= 21 |pages= 7437-47 |year= 2003 |pmid= 14559993 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Dettwiler S, Aringhieri C, Cardinale S, etal |title=Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 34 |pages= 35788–97 |year= 2005 |pmid= 15169763 |doi= 10.1074/jbc.M403927200 }}
*{{cite journal | author=Dettwiler S, Aringhieri C, Cardinale S, ''et al.'' |title=Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 34 |pages= 35788-97 |year= 2005 |pmid= 15169763 |doi= 10.1074/jbc.M403927200 }}
*{{cite journal  |author1=Lehner B |author2=Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
}}
}}
{{refend}}
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{{gene-6-stub}}

Latest revision as of 04:33, 26 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Splicing factor, arginine/serine-rich 3 is a protein that in humans is encoded by the SFRS3 gene.[1][2]


Browser View

UCSC Genome Browser View

UCSC Gene details page

Interactions

SFRS3 has been shown to interact with RBM7.[3]

References

  1. ↑ Zahler AM; Lane WS; Stolk JA; Roth MB (Jun 1992). "SR proteins: a conserved family of pre-mRNA splicing factors". Genes Dev. 6 (5): 837–47. doi:10.1101/gad.6.5.837. PMID 1577277.
  2. ↑ "Entrez Gene: SFRS3 splicing factor, arginine/serine-rich 3".
  3. ↑ Guo, Taylor B; Boros Laszlo G; Chan Kam C; Hikim Amiya P Sinha; Hudson Alan P; Swerdloff Ronald S; Mitchell Aaron P; Salameh Wael A (2003). "Spermatogenetic expression of RNA-binding motif protein 7, a protein that interacts with splicing factors". J. Androl. United States. 24 (2): 204–14. doi:10.1002/j.1939-4640.2003.tb02664.x. ISSN 0196-3635. PMID 12634307.

Further reading



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