SYNCRIP: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Synaptotagmin binding, cytoplasmic RNA interacting protein''', also known as '''Heterogeneous nuclear ribonucleoprotein Q''' is a [[protein]] that in humans is encoded by the ''SYNCRIP'' [[gene]].<ref name="pmid9847309">{{cite journal | vauthors = Harris CE, Boden RA, Astell CR | title = A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice | journal = Journal of Virology | volume = 73 | issue = 1 | pages = 72–80 | date = January 1999 | pmid = 9847309 | pmc = 103810 | doi =  }}</ref><ref name="pmid11352648">{{cite journal | vauthors = Lau PP, Chang BH, Chan L | title = Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome | journal = Biochemical and Biophysical Research Communications | volume = 282 | issue = 4 | pages = 977–83 | date = April 2001 | pmid = 11352648 | pmc =  | doi = 10.1006/bbrc.2001.4679 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10492| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_SYNCRIP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dgu.
| PDB = {{PDB2|2dgu}}
| Name = Synaptotagmin binding, cytoplasmic RNA interacting protein
| HGNCid = 16918
| Symbol = SYNCRIP
| AltSymbols =; GRY-RBP; HNRPQ1; NSAP1; RP1-3J17.2; dJ3J17.2; pp68
| OMIM = 
| ECnumber = 
| Homologene = 4648
| MGIid = 1891690
| GeneAtlas_image1 = PBB_GE_SYNCRIP_217833_at_tn.png
| GeneAtlas_image2 = PBB_GE_SYNCRIP_209024_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SYNCRIP_217832_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008143 |text = poly(A) binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10492
    | Hs_Ensembl = ENSG00000135316
    | Hs_RefseqProtein = NP_006363
    | Hs_RefseqmRNA = NM_006372
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 86374772
    | Hs_GenLoc_end = 86409722
    | Hs_Uniprot = O60506
    | Mm_EntrezGene = 56403
    | Mm_Ensembl = ENSMUSG00000032423
    | Mm_RefseqmRNA = NM_019666
    | Mm_RefseqProtein = NP_062640
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 88250166
    | Mm_GenLoc_end = 88280101
    | Mm_Uniprot = Q2YDV8
  }}
}}
'''Synaptotagmin binding, cytoplasmic RNA interacting protein''', also known as '''SYNCRIP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10492| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
SYNCRIP has been shown to [[Protein-protein interaction|interact]] with [[ACF (gene)|ACF]],<ref name=pmid11352648 /><ref name=pmid11134005>{{cite journal | vauthors = Blanc V, Navaratnam N, Henderson JO, Anant S, Kennedy S, Jarmuz A, Scott J, Davidson NO | title = Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing | journal = The Journal of Biological Chemistry | volume = 276 | issue = 13 | pages = 10272–83 | date = March 2001 | pmid = 11134005 | doi = 10.1074/jbc.M006435200 }}</ref> [[APOBEC1]],<ref name=pmid11352648/> [[SYT7]]<ref name=pmid10734137>{{cite journal | vauthors = Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K | title = SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms | journal = The Journal of Biological Chemistry | volume = 275 | issue = 13 | pages = 9823–31 | date = March 2000 | pmid = 10734137 | doi = 10.1074/jbc.275.13.9823 }}</ref> and [[SYT9]],<ref name=pmid10734137/>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Fu C, Chan AC |title=Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27362-8 |year= 1997 |pmid= 9341187 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Neubauer G, King A, Rappsilber J, ''et al.'' |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46-50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700 }}
*{{cite journal  | author=Harris CE, Boden RA, Astell CR |title=A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice. |journal=J. Virol. |volume=73 |issue= 1 |pages= 72-80 |year= 1999 |pmid= 9847309 |doi=  }}
*{{cite journal  | author=Mizutani A, Fukuda M, Ibata K, ''et al.'' |title=SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms. |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9823-31 |year= 2000 |pmid= 10734137 |doi=  }}
*{{cite journal  | author=Grosset C, Chen CY, Xu N, ''et al.'' |title=A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. |journal=Cell |volume=103 |issue= 1 |pages= 29-40 |year= 2000 |pmid= 11051545 |doi=  }}
*{{cite journal  | author=Blanc V, Navaratnam N, Henderson JO, ''et al.'' |title=Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing. |journal=J. Biol. Chem. |volume=276 |issue= 13 |pages= 10272-83 |year= 2001 |pmid= 11134005 |doi= 10.1074/jbc.M006435200 }}
*{{cite journal  | author=Lau PP, Chang BH, Chan L |title=Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 4 |pages= 977-83 |year= 2001 |pmid= 11352648 |doi= 10.1006/bbrc.2001.4679 }}
*{{cite journal  | author=Mourelatos Z, Abel L, Yong J, ''et al.'' |title=SMN interacts with a novel family of hnRNP and spliceosomal proteins. |journal=EMBO J. |volume=20 |issue= 19 |pages= 5443-52 |year= 2001 |pmid= 11574476 |doi= 10.1093/emboj/20.19.5443 }}
*{{cite journal  | author=Rossoll W, Kröning AK, Ohndorf UM, ''et al.'' |title=Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons? |journal=Hum. Mol. Genet. |volume=11 |issue= 1 |pages= 93-105 |year= 2002 |pmid= 11773003 |doi=  }}
*{{cite journal  | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi=  }}
*{{cite journal  | author=Hresko RC, Mueckler M |title=Identification of pp68 as the Tyrosine-phosphorylated Form of SYNCRIP/NSAP1. A cytoplasmic RNA-binding protein. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25233-8 |year= 2002 |pmid= 11994298 |doi= 10.1074/jbc.M202556200 }}
*{{cite journal  | author=Carty SM, Greenleaf AL |title=Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing. |journal=Mol. Cell Proteomics |volume=1 |issue= 8 |pages= 598-610 |year= 2003 |pmid= 12376575 |doi=  }}
*{{cite journal  | author=Angenstein F, Evans AM, Settlage RE, ''et al.'' |title=A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. |journal=J. Neurosci. |volume=22 |issue= 20 |pages= 8827-37 |year= 2002 |pmid= 12388589 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Hinsby AM, Olsen JV, Bennett KL, Mann M |title=Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry. |journal=Mol. Cell Proteomics |volume=2 |issue= 1 |pages= 29-36 |year= 2003 |pmid= 12601080 |doi=  }}
*{{cite journal  | author=Moraes KC, Quaresma AJ, Maehnss K, Kobarg J |title=Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D). |journal=Biol. Chem. |volume=384 |issue= 1 |pages= 25-37 |year= 2003 |pmid= 12674497 |doi=  }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Kim JH, Paek KY, Ha SH, ''et al.'' |title=A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon. |journal=Mol. Cell. Biol. |volume=24 |issue= 18 |pages= 7878-90 |year= 2004 |pmid= 15340051 |doi= 10.1128/MCB.24.18.7878-7890.2004 }}
}}
{{refend}}


{{protein-stub}}
== Further reading ==
{{WikiDoc Sources}}
{{Refbegin | 2}}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Fu C, Chan AC | title = Identification of two tyrosine phosphoproteins, pp70 and pp68, which interact with phospholipase Cgamma, Grb2, and Vav after B cell antigen receptor activation | journal = The Journal of Biological Chemistry | volume = 272 | issue = 43 | pages = 27362–8 | date = October 1997 | pmid = 9341187 | doi = 10.1074/jbc.272.43.27362 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M | title = Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex | journal = Nature Genetics | volume = 20 | issue = 1 | pages = 46–50 | date = September 1998 | pmid = 9731529 | doi = 10.1038/1700 }}
* {{cite journal | vauthors = Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K | title = SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms | journal = The Journal of Biological Chemistry | volume = 275 | issue = 13 | pages = 9823–31 | date = March 2000 | pmid = 10734137 | doi = 10.1074/jbc.275.13.9823 }}
* {{cite journal | vauthors = Grosset C, Chen CY, Xu N, Sonenberg N, Jacquemin-Sablon H, Shyu AB | title = A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex | journal = Cell | volume = 103 | issue = 1 | pages = 29–40 | date = September 2000 | pmid = 11051545 | doi = 10.1016/S0092-8674(00)00102-1 }}
* {{cite journal | vauthors = Blanc V, Navaratnam N, Henderson JO, Anant S, Kennedy S, Jarmuz A, Scott J, Davidson NO | title = Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing | journal = The Journal of Biological Chemistry | volume = 276 | issue = 13 | pages = 10272–83 | date = March 2001 | pmid = 11134005 | doi = 10.1074/jbc.M006435200 }}
* {{cite journal | vauthors = Mourelatos Z, Abel L, Yong J, Kataoka N, Dreyfuss G | title = SMN interacts with a novel family of hnRNP and spliceosomal proteins | journal = The EMBO Journal | volume = 20 | issue = 19 | pages = 5443–52 | date = October 2001 | pmid = 11574476 | pmc = 125643 | doi = 10.1093/emboj/20.19.5443 }}
* {{cite journal | vauthors = Rossoll W, Kröning AK, Ohndorf UM, Steegborn C, Jablonka S, Sendtner M | title = Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons? | journal = Human Molecular Genetics | volume = 11 | issue = 1 | pages = 93–105 | date = January 2002 | pmid = 11773003 | doi = 10.1093/hmg/11.1.93 }}
* {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = RNA | volume = 8 | issue = 4 | pages = 426–39 | date = April 2002 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }}
* {{cite journal | vauthors = Hresko RC, Mueckler M | title = Identification of pp68 as the Tyrosine-phosphorylated Form of SYNCRIP/NSAP1. A cytoplasmic RNA-binding protein | journal = The Journal of Biological Chemistry | volume = 277 | issue = 28 | pages = 25233–8 | date = July 2002 | pmid = 11994298 | doi = 10.1074/jbc.M202556200 }}
* {{cite journal | vauthors = Carty SM, Greenleaf AL | title = Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing | journal = Molecular & Cellular Proteomics | volume = 1 | issue = 8 | pages = 598–610 | date = August 2002 | pmid = 12376575 | doi = 10.1074/mcp.M200029-MCP200 }}
* {{cite journal | vauthors = Angenstein F, Evans AM, Settlage RE, Moran ST, Ling SC, Klintsova AY, Shabanowitz J, Hunt DF, Greenough WT | title = A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons | journal = The Journal of Neuroscience | volume = 22 | issue = 20 | pages = 8827–37 | date = October 2002 | pmid = 12388589 | doi =  }}
* {{cite journal | vauthors = Hinsby AM, Olsen JV, Bennett KL, Mann M | title = Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry | journal = Molecular & Cellular Proteomics | volume = 2 | issue = 1 | pages = 29–36 | date = January 2003 | pmid = 12601080 | doi = 10.1074/mcp.M200075-MCP200 }}
* {{cite journal | vauthors = Moraes KC, Quaresma AJ, Maehnss K, Kobarg J | title = Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D) | journal = Biological Chemistry | volume = 384 | issue = 1 | pages = 25–37 | date = January 2003 | pmid = 12674497 | doi = 10.1515/BC.2003.004 }}
* {{cite journal | vauthors = Kim JH, Paek KY, Ha SH, Cho S, Choi K, Kim CS, Ryu SH, Jang SK | title = A cellular RNA-binding protein enhances internal ribosomal entry site-dependent translation through an interaction downstream of the hepatitis C virus polyprotein initiation codon | journal = Molecular and Cellular Biology | volume = 24 | issue = 18 | pages = 7878–90 | date = September 2004 | pmid = 15340051 | pmc = 515056 | doi = 10.1128/MCB.24.18.7878-7890.2004 }}
* {{cite journal | vauthors = Quaresma AJ, Bressan GC, Gava LM, Lanza DC, Ramos CH, Kobarg J | title = Human hnRNP Q re-localizes to cytoplasmic granules upon PMA, thapsigargin, arsenite and heat-shock treatments | journal = Experimental Cell Research | volume = 315 | issue = 6 | pages = 968–80 | date = April 2009 | pmid = 19331829 | pmc =  | doi = 10.1016/j.yexcr.2009.01.012 }}
* {{cite journal | vauthors = Moraes KC, Quaresma AJ, Maehnss K, Kobarg J | title = Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP D) | journal = Biological Chemistry | volume = 384 | issue = 1 | pages = 25–37 | date = January 2003 | pmid = 12674497 | doi = 10.1515/BC.2003.004 | ISSN = 1431-6730 }}
{{Refend}}
{{PDB Gallery|geneid=10492}}
 
 
{{Gene-6-stub}}

Latest revision as of 01:20, 28 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Synaptotagmin binding, cytoplasmic RNA interacting protein, also known as Heterogeneous nuclear ribonucleoprotein Q is a protein that in humans is encoded by the SYNCRIP gene.[1][2][3]

Interactions

SYNCRIP has been shown to interact with ACF,[2][4] APOBEC1,[2] SYT7[5] and SYT9,[5]

References

  1. Harris CE, Boden RA, Astell CR (January 1999). "A novel heterogeneous nuclear ribonucleoprotein-like protein interacts with NS1 of the minute virus of mice". Journal of Virology. 73 (1): 72–80. PMC 103810. PMID 9847309.
  2. 2.0 2.1 2.2 Lau PP, Chang BH, Chan L (April 2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec-1 editosome". Biochemical and Biophysical Research Communications. 282 (4): 977–83. doi:10.1006/bbrc.2001.4679. PMID 11352648.
  3. "Entrez Gene: SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein".
  4. Blanc V, Navaratnam N, Henderson JO, Anant S, Kennedy S, Jarmuz A, Scott J, Davidson NO (March 2001). "Identification of GRY-RBP as an apolipoprotein B RNA-binding protein that interacts with both apobec-1 and apobec-1 complementation factor to modulate C to U editing". The Journal of Biological Chemistry. 276 (13): 10272–83. doi:10.1074/jbc.M006435200. PMID 11134005.
  5. 5.0 5.1 Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (March 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.

Further reading