RGS1: Difference between revisions

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'''Regulator of G-protein signaling 1''' is a [[protein]] that in humans is encoded by the ''RGS1'' [[gene]].<ref name="pmid8241276">{{cite journal | vauthors = Newton JS, Deed RW, Mitchell EL, Murphy JJ, Norton JD | title = A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein | journal = Biochim Biophys Acta | volume = 1216 | issue = 2 | pages = 314–6 |date=Jan 1994 | pmid = 8241276 | pmc =  | doi =  10.1016/0167-4781(93)90163-8}}</ref><ref name="pmid8602223">{{cite journal | vauthors = Druey KM, Blumer KJ, Kang VH, Kehrl JH | title = Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family | journal = Nature | volume = 379 | issue = 6567 | pages = 742–6 |date=May 1996 | pmid = 8602223 | pmc =  | doi = 10.1038/379742a0 }}</ref><ref name="entrez"/>
'''Regulator of G-protein signaling 1''' is a [[protein]] that in humans is encoded by the ''RGS1'' [[gene]].<ref name="pmid8241276">{{cite journal | vauthors = Newton JS, Deed RW, Mitchell EL, Murphy JJ, Norton JD | title = A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein | journal = Biochim Biophys Acta | volume = 1216 | issue = 2 | pages = 314–6 |date=Jan 1994 | pmid = 8241276 | pmc =  | doi =  10.1016/0167-4781(93)90163-8}}</ref><ref name="pmid8602223">{{cite journal | vauthors = Druey KM, Blumer KJ, Kang VH, Kehrl JH | title = Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family | journal = Nature | volume = 379 | issue = 6567 | pages = 742–6 |date=May 1996 | pmid = 8602223 | pmc =  | doi = 10.1038/379742a0 }}</ref><ref name="entrez"/>
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{{PBB_Summary
{{PBB_Summary
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| summary_text = This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.<ref name="entrez">{{cite web | title = Entrez Gene: RGS1 regulator of G-protein signalling 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5996| accessdate = }}</ref>
| summary_text = This gene encodes a member of the regulator of G-protein signaling family. This protein is located on the [[cytosolic]] side of the [[plasma membrane]] and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of [[G-proteins]] by binding to activated, GTP-bound G alpha subunits and acting as a [[GTPase activating protein]] (GAP), increasing the rate of conversion of the GTP to GDP. This [[hydrolysis]] allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.<ref name="entrez">{{cite web | title = Entrez Gene: RGS1 regulator of G-protein signalling 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5996| accessdate = }}</ref>
}}
}}


Latest revision as of 16:59, 19 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.[1][2][3]

This gene encodes a member of the regulator of G-protein signaling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.[3]

References

  1. ↑ Newton JS, Deed RW, Mitchell EL, Murphy JJ, Norton JD (Jan 1994). "A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein". Biochim Biophys Acta. 1216 (2): 314–6. doi:10.1016/0167-4781(93)90163-8. PMID 8241276.
  2. ↑ Druey KM, Blumer KJ, Kang VH, Kehrl JH (May 1996). "Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family". Nature. 379 (6567): 742–6. doi:10.1038/379742a0. PMID 8602223.
  3. ↑ 3.0 3.1 "Entrez Gene: RGS1 regulator of G-protein signalling 1".

Further reading



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