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{{Infobox_gene}}
{{PBB_Controls
'''[[Calsyntenin]]-1''' is a [[protein]] that in humans is encoded by the ''CLSTN1'' [[gene]].<ref name="pmid10048485">{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 6 | pages = 355–64 | date = Dec 1998 | pmid = 10048485 | pmc =  | doi = 10.1093/dnares/5.6.355 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CLSTN1 calsyntenin 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22883| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical relevance ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Calsyntenin 1
| HGNCid = 17447
| Symbol = CLSTN1
| AltSymbols =; PIK3CD; CSTN1; FLJ32258; KIAA0911; XB31alpha; alcalpha1; alcalpha2
| OMIM = 
| ECnumber = 
| Homologene = 8814
| MGIid = 1929895
| GeneAtlas_image1 = PBB_GE_CLSTN1_201561_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045211 |text = postsynaptic membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007156 |text = homophilic cell adhesion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22883
    | Hs_Ensembl = ENSG00000171603
    | Hs_RefseqProtein = NP_001009566
    | Hs_RefseqmRNA = NM_001009566
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 9711671
    | Hs_GenLoc_end = 9807171
    | Hs_Uniprot = O94985
    | Mm_EntrezGene = 65945
    | Mm_Ensembl = ENSMUSG00000039953
    | Mm_RefseqmRNA = NM_023051
    | Mm_RefseqProtein = NP_075538
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 148430228
    | Mm_GenLoc_end = 148492698
    | Mm_Uniprot = Q8K103
  }}
}}
'''Calsyntenin 1''', also known as '''CLSTN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CLSTN1 calsyntenin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22883| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
Mutations in this gene have been shown associated to pathogenic mechanisms of [[Alzheimer's disease]].<ref name="doi.10.1093/hmg/dds109">{{cite journal | vauthors = Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC | title = Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production | journal = Human Molecular Genetics | volume = 21 | issue = 13 | pages = 2845–54 | date = Jul 2012 | pmid = 22434822 | doi = 10.1093/hmg/dds109 | pmc=3373235}}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CLSTN1 has been shown to [[Protein-protein interaction|interact]] with [[APBA2]]<ref name=pmid12972431>{{cite journal | vauthors = Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T | title = Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism | journal = The Journal of Biological Chemistry | volume = 278 | issue = 49 | pages = 49448–58 | date = Dec 2003 | pmid = 12972431 | doi = 10.1074/jbc.M306024200 }}</ref><ref name=pmid15037614>{{cite journal | vauthors = Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T | title = Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 23 | pages = 24343–54 | date = Jun 2004 | pmid = 15037614 | doi = 10.1074/jbc.M401925200 }}</ref> and [[Amyloid precursor protein]].<ref name=pmid12972431/><ref name=pmid15037614/>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|CLSTN1}}
* {{UCSC gene info|PIK3CD}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Konecna A, Frischknecht R, Kinter J, Ludwig A, Steuble M, Meskenaite V, Indermühle M, Engel M, Cen C, Mateos JM, Streit P, Sonderegger P | title = Calsyntenin-1 docks vesicular cargo to kinesin-1 | journal = Molecular Biology of the Cell | volume = 17 | issue = 8 | pages = 3651–63 | date = Aug 2006 | pmid = 16760430 | pmc = 1525238 | doi = 10.1091/mbc.E06-02-0112 | url = http://www.zora.uzh.ch/1134/1/KonecnaSonderegger2006V.pdf }}
| citations =
* {{cite journal | vauthors = Schmitt-Ulms G, Hansen K, Liu J, Cowdrey C, Yang J, DeArmond SJ, Cohen FE, Prusiner SB, Baldwin MA | title = Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 724–31 | date = Jun 2004 | pmid = 15146195 | doi = 10.1038/nbt969 }}
*{{cite journal | author=Konecna A, Frischknecht R, Kinter J, ''et al.'' |title=Calsyntenin-1 docks vesicular cargo to kinesin-1. |journal=Mol. Biol. Cell |volume=17 |issue= 8 |pages= 3651-63 |year= 2006 |pmid= 16760430 |doi= 10.1091/mbc.E06-02-0112 }}
* {{cite journal | vauthors = Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T | title = Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation | journal = The Journal of Biological Chemistry | volume = 279 | issue = 23 | pages = 24343–54 | date = Jun 2004 | pmid = 15037614 | doi = 10.1074/jbc.M401925200 }}
*{{cite journal  | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
* {{cite journal | vauthors = Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T | title = Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism | journal = The Journal of Biological Chemistry | volume = 278 | issue = 49 | pages = 49448–58 | date = Dec 2003 | pmid = 12972431 | doi = 10.1074/jbc.M306024200 }}
*{{cite journal | author=Schmitt-Ulms G, Hansen K, Liu J, ''et al.'' |title=Time-controlled transcardiac perfusion cross-linking for the study of protein interactions in complex tissues. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 724-31 |year= 2005 |pmid= 15146195 |doi= 10.1038/nbt969 }}
* {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Research | volume = 12 | issue = 11 | pages = 1773–84 | date = Nov 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
*{{cite journal | author=Araki Y, Miyagi N, Kato N, ''et al.'' |title=Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24343-54 |year= 2004 |pmid= 15037614 |doi= 10.1074/jbc.M401925200 }}
* {{cite journal | vauthors = Vogt L, Schrimpf SP, Meskenaite V, Frischknecht R, Kinter J, Leone DP, Ziegler U, Sonderegger P | title = Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain | journal = Molecular and Cellular Neurosciences | volume = 17 | issue = 1 | pages = 151–66 | date = Jan 2001 | pmid = 11161476 | doi = 10.1006/mcne.2000.0937 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Araki Y, Tomita S, Yamaguchi H, ''et al.'' |title=Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism. |journal=J. Biol. Chem. |volume=278 |issue= 49 |pages= 49448-58 |year= 2004 |pmid= 12972431 |doi= 10.1074/jbc.M306024200 }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
*{{cite journal | author=Vogt L, Schrimpf SP, Meskenaite V, ''et al.'' |title=Calsyntenin-1, a proteolytically processed postsynaptic membrane protein with a cytoplasmic calcium-binding domain. |journal=Mol. Cell. Neurosci. |volume=17 |issue= 1 |pages= 151-66 |year= 2001 |pmid= 11161476 |doi= 10.1006/mcne.2000.0937 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355-64 |year= 1999 |pmid= 10048485 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
}}
{{refend}}
{{refend}}


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Latest revision as of 13:45, 4 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Calsyntenin-1 is a protein that in humans is encoded by the CLSTN1 gene.[1][2]

Clinical relevance

Mutations in this gene have been shown associated to pathogenic mechanisms of Alzheimer's disease.[3]

Interactions

CLSTN1 has been shown to interact with APBA2[4][5] and Amyloid precursor protein.[4][5]

References

  1. ↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
  2. ↑ "Entrez Gene: CLSTN1 calsyntenin 1".
  3. ↑ Vagnoni A, Perkinton MS, Gray EH, Francis PT, Noble W, Miller CC (Jul 2012). "Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates Aβ production". Human Molecular Genetics. 21 (13): 2845–54. doi:10.1093/hmg/dds109. PMC 3373235. PMID 22434822.
  4. ↑ 4.0 4.1 Araki Y, Tomita S, Yamaguchi H, Miyagi N, Sumioka A, Kirino Y, Suzuki T (Dec 2003). "Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological Chemistry. 278 (49): 49448–58. doi:10.1074/jbc.M306024200. PMID 12972431.
  5. ↑ 5.0 5.1 Araki Y, Miyagi N, Kato N, Yoshida T, Wada S, Nishimura M, Komano H, Yamamoto T, De Strooper B, Yamamoto K, Suzuki T (Jun 2004). "Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation". The Journal of Biological Chemistry. 279 (23): 24343–54. doi:10.1074/jbc.M401925200. PMID 15037614.

External links

Further reading


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