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'''Intelectin-1''', also known as '''omentin''' or '''intestinal lactoferrin receptor''', is an [[intelectin]] encoded in humans by the ''ITLN1'' [[gene]].<ref name="pmid11313366">{{cite journal | vauthors = Tsuji S, Uehori J, Matsumoto M, Suzuki Y, Matsuhisa A, Toyoshima K, Seya T | title = Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall | journal = J Biol Chem | volume = 276 | issue = 26 | pages = 23456–63 | date = Jun 2001 | pmid = 11313366 | pmc =  | doi = 10.1074/jbc.M103162200 }}</ref><ref name="pmid11181563">{{cite journal | vauthors = Lee JK, Schnee J, Pang M, Wolfert M, Baum LG, Moremen KW, Pierce M | title = Human homologs of the Xenopus oocyte cortical granule lectin XL35 | journal = Glycobiology | volume = 11 | issue = 1 | pages = 65–73 | date = Feb 2001 | pmid = 11181563 | pmc =  | doi = 10.1093/glycob/11.1.65 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ITLN1 intelectin 1 (galactofuranose binding)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55600| accessdate = }}</ref> Intelectin-1 functions both as a receptor for bacterial [[arabinogalactan]]s<ref name="pmid11313366"/> and for [[lactoferrin]].<ref name="pmid11747454">{{cite journal | vauthors = Suzuki YA, Shin K, Lönnerdal B | title = Molecular cloning and functional expression of a human intestinal lactoferrin receptor | journal = Biochemistry | volume = 40 | issue = 51 | pages = 15771–9 | date = December 2001 | pmid = 11747454 | doi = 10.1021/bi0155899 | url =  }}</ref>
'''Intelectin-1''', also known as '''omentin''' or '''intestinal lactoferrin receptor''', is an [[intelectin]] encoded in humans by the ''ITLN1'' [[gene]].<ref name="pmid11313366">{{cite journal | vauthors = Tsuji S, Uehori J, Matsumoto M, Suzuki Y, Matsuhisa A, Toyoshima K, Seya T | title = Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall | journal = J Biol Chem | volume = 276 | issue = 26 | pages = 23456–63 | date = Jun 2001 | pmid = 11313366 | pmc =  | doi = 10.1074/jbc.M103162200 }}</ref><ref name="pmid11181563">{{cite journal | vauthors = Lee JK, Schnee J, Pang M, Wolfert M, Baum LG, Moremen KW, Pierce M | title = Human homologs of the Xenopus oocyte cortical granule lectin XL35 | journal = Glycobiology | volume = 11 | issue = 1 | pages = 65–73 | date = Feb 2001 | pmid = 11181563 | pmc =  | doi = 10.1093/glycob/11.1.65 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ITLN1 intelectin 1 (galactofuranose binding)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55600| accessdate = }}</ref> Intelectin-1 functions both as a receptor for bacterial [[arabinogalactan]]s<ref name="pmid11313366"/> and for [[lactoferrin]].<ref name="pmid11747454">{{cite journal | vauthors = Suzuki YA, Shin K, Lönnerdal B | title = Molecular cloning and functional expression of a human intestinal lactoferrin receptor | journal = Biochemistry | volume = 40 | issue = 51 | pages = 15771–9 | date = December 2001 | pmid = 11747454 | doi = 10.1021/bi0155899 | url =  }}</ref>


Having conserved ligand binding site residues, both human and mouse intelectin-1 bind the exocyclic vicinal diol of carbohydrate ligands such as galactofuranose.<ref>{{cite journal|last1=Wesener|first1=Darryl A|last2=Wangkanont|first2=Kittikhun|last3=McBride|first3=Ryan|last4=Song|first4=Xuezheng|last5=Kraft|first5=Matthew B|last6=Hodges|first6=Heather L|last7=Zarling|first7=Lucas C|last8=Splain|first8=Rebecca A|last9=Smith|first9=David F|last10=Cummings|first10=Richard D|last11=Paulson|first11=James C|last12=Forest|first12=Katrina T|last13=Kiessling|first13=Laura L|title=Recognition of microbial glycans by human intelectin-1|journal=Nature Structural & Molecular Biology|date=6 July 2015|volume=22|issue=8|pages=603–610|doi=10.1038/nsmb.3053|pmid=26148048|pmc=4526365}}</ref><ref>{{cite journal|last1=Wangkanont|first1=K|last2=Wesener|first2=DA|last3=Vidani|first3=JA|last4=Kiessling|first4=LL|last5=Forest|first5=KT|title=Structures of Xenopus embryonic epidermal lectin reveal a conserved mechanism of microbial glycan recognition.|journal=The Journal of Biological Chemistry|date=11 January 2016|pmid=26755729|doi=10.1074/jbc.M115.709212|volume=291|pages=5596–610}}</ref>
Having conserved ligand binding site residues, both human and mouse intelectin-1 bind the exocyclic vicinal diol of carbohydrate ligands such as galactofuranose.<ref>{{cite journal|last1=Wesener|first1=Darryl A|last2=Wangkanont|first2=Kittikhun|last3=McBride|first3=Ryan|last4=Song|first4=Xuezheng|last5=Kraft|first5=Matthew B|last6=Hodges|first6=Heather L|last7=Zarling|first7=Lucas C|last8=Splain|first8=Rebecca A|last9=Smith|first9=David F|last10=Cummings|first10=Richard D|last11=Paulson|first11=James C|last12=Forest|first12=Katrina T|last13=Kiessling|first13=Laura L|title=Recognition of microbial glycans by human intelectin-1|journal=Nature Structural & Molecular Biology|date=6 July 2015|volume=22|issue=8|pages=603–610|doi=10.1038/nsmb.3053|pmid=26148048|pmc=4526365}}</ref><ref>{{cite journal|last1=Wangkanont|first1=K|last2=Wesener|first2=DA|last3=Vidani|first3=JA|last4=Kiessling|first4=LL|last5=Forest|first5=KT|title=Structures of Xenopus embryonic epidermal lectin reveal a conserved mechanism of microbial glycan recognition.|journal=The Journal of Biological Chemistry|date=11 January 2016|pmid=26755729|doi=10.1074/jbc.M115.709212|volume=291|pages=5596–610|pmc=4786701}}</ref>


== See also ==
== See also ==

Latest revision as of 11:07, 16 May 2018

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Orthologs
SpeciesHumanMouse
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Intelectin-1, also known as omentin or intestinal lactoferrin receptor, is an intelectin encoded in humans by the ITLN1 gene.[1][2][3] Intelectin-1 functions both as a receptor for bacterial arabinogalactans[1] and for lactoferrin.[4]

Having conserved ligand binding site residues, both human and mouse intelectin-1 bind the exocyclic vicinal diol of carbohydrate ligands such as galactofuranose.[5][6]

See also

References

  1. 1.0 1.1 Tsuji S, Uehori J, Matsumoto M, Suzuki Y, Matsuhisa A, Toyoshima K, Seya T (Jun 2001). "Human intelectin is a novel soluble lectin that recognizes galactofuranose in carbohydrate chains of bacterial cell wall". J Biol Chem. 276 (26): 23456–63. doi:10.1074/jbc.M103162200. PMID 11313366.
  2. Lee JK, Schnee J, Pang M, Wolfert M, Baum LG, Moremen KW, Pierce M (Feb 2001). "Human homologs of the Xenopus oocyte cortical granule lectin XL35". Glycobiology. 11 (1): 65–73. doi:10.1093/glycob/11.1.65. PMID 11181563.
  3. "Entrez Gene: ITLN1 intelectin 1 (galactofuranose binding)".
  4. Suzuki YA, Shin K, Lönnerdal B (December 2001). "Molecular cloning and functional expression of a human intestinal lactoferrin receptor". Biochemistry. 40 (51): 15771–9. doi:10.1021/bi0155899. PMID 11747454.
  5. Wesener, Darryl A; Wangkanont, Kittikhun; McBride, Ryan; Song, Xuezheng; Kraft, Matthew B; Hodges, Heather L; Zarling, Lucas C; Splain, Rebecca A; Smith, David F; Cummings, Richard D; Paulson, James C; Forest, Katrina T; Kiessling, Laura L (6 July 2015). "Recognition of microbial glycans by human intelectin-1". Nature Structural & Molecular Biology. 22 (8): 603–610. doi:10.1038/nsmb.3053. PMC 4526365. PMID 26148048.
  6. Wangkanont, K; Wesener, DA; Vidani, JA; Kiessling, LL; Forest, KT (11 January 2016). "Structures of Xenopus embryonic epidermal lectin reveal a conserved mechanism of microbial glycan recognition". The Journal of Biological Chemistry. 291: 5596–610. doi:10.1074/jbc.M115.709212. PMC 4786701. PMID 26755729.

Further reading