OR7D4: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Olfactory receptor 7D4''' is a [[protein]] that in humans is encoded by the ''OR7D4'' [[gene]].<ref name="entrez"/><ref>{{cite journal | vauthors = Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R | title = DEFOG: a practical scheme for deciphering families of genes | journal = Genomics | volume = 80 | issue = 3 | pages = 295–302 | date = September 2002 | pmid = 12213199 | pmc =  | doi = 10.1006/geno.2002.6830 }}</ref><ref>{{cite journal | vauthors = Malnic B, Godfrey PA, Buck LB | title = The human olfactory receptor gene family | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 8 | pages = 2584–9 | date = February 2004 | pmid = 14983052 | pmc = 356993 | doi = 10.1073/pnas.0307882100 }}</ref><ref>{{cite journal | vauthors = Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H | title = Genetic variation in a human odorant receptor alters odour perception | journal = Nature | volume = 449 | issue = 7161 | pages = 468–72 | date = September 2007 | pmid = 17873857 | pmc =  | doi = 10.1038/nature06162 }}</ref><ref name="mesh">{{MeshName|OR7D4+protein,+human}}</ref><ref>{{cite journal | vauthors = Lunde K, Egelandsdal B, Skuterud E, Mainland JD, Lea T, Hersleth M, Matsunami H | title = Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone | journal = PLOS One | volume = 7 | issue = 5 | pages = e35259 | year = 2012 | pmid = 22567099 | pmc = 3342276 | doi = 10.1371/journal.pone.0035259 | editor1-last = Behrens | editor1-first = Maik }}</ref><ref>{{cite journal | vauthors = Wysocki CJ, Beauchamp GK | title = Ability to smell androstenone is genetically determined | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 81 | issue = 15 | pages = 4899–902 | date = August 1984 | pmid = 6589634 | pmc = 391599 | doi = 10.1073/pnas.81.15.4899 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 7, subfamily D, member 4
| HGNCid = 8380
| Symbol = OR7D4
| AltSymbols =; OR19-7; OR19-B; OR7D4P; hg105
| OMIM = 
| ECnumber = 
| Homologene = 81583
| MGIid = 1313142
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 125958
    | Hs_Ensembl = ENSG00000174667
    | Hs_RefseqProtein = NP_001005191
    | Hs_RefseqmRNA = NM_001005191
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 9185575
    | Hs_GenLoc_end = 9186513
    | Hs_Uniprot = Q8NG98
    | Mm_EntrezGene = 258822
    | Mm_Ensembl = ENSMUSG00000059623
    | Mm_RefseqmRNA = NM_146825
    | Mm_RefseqProtein = NP_667036
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 20036103
    | Mm_GenLoc_end = 20037038
    | Mm_Uniprot = 
  }}
}}
'''Olfactory receptor, family 7, subfamily D, member 4''', also known as '''OR7D4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR7D4 olfactory receptor, family 7, subfamily D, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=125958| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Olfactory receptor]]s interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of [[G protein-coupled receptor]]s (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR7D4 olfactory receptor, family 7, subfamily D, member 4| url = https://www.ncbi.nlm.nih.gov/gene/125958| access-date =2013-12-17 }}</ref>
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR7D4 olfactory receptor, family 7, subfamily D, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=125958| accessdate = }}</ref>
}}


==See also==
==Ligands==
* [[Olfactory receptor]]


==References==
* [[Androstadienone]] <ref>{{cite journal | vauthors = Hornung J, Noack H, Thomas M, Farger G, Nieratschker V, Freiherr J, Derntl B | title = Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction | journal = Hormones and Behavior | volume = 98 | pages = 45–54 | date = February 2018 | pmid = 29246659 | doi = 10.1016/j.yhbeh.2017.12.003 }}</ref>
{{reflist|2}}
* [[Androstenone]] <ref>{{cite journal | vauthors = de March CA, Topin J, Bruguera E, Novikov G, Ikegami K, Matsunami H, Golebiowski J | title = Odorant Receptor 7D4 Activation Dynamics | journal = Angewandte Chemie | volume = 57 | issue = 17 | pages = 4554–4558 | date = April 2018 | pmid = 29462498 | doi = 10.1002/anie.201713065 }}</ref>


==Further reading==
== References ==
{{refbegin | 2}}
{{reflist}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi=  }}
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
*{{cite journal  | author=Keller A, Zhuang H, Chi Q, ''et al.'' |title=Genetic variation in a human odorant receptor alters odour perception. |journal=Nature |volume=449 |issue= 7161 |pages= 468-72 |year= 2007 |pmid= 17873857 |doi= 10.1038/nature06162 }}
}}
{{refend}}


== External links ==
{{NLM content}}
* {{MeshName|OR7D4+protein,+human}}


{{NLM content}}
{{membrane-protein-stub}}
{{Olfactory receptors}}
{{Olfactory receptors}}
[[Category:G protein coupled receptors]]
 
{{WikiDoc Sources}}
[[Category:Olfactory receptors]]
 
 
{{transmembranereceptor-stub}}

Latest revision as of 12:51, 9 August 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Olfactory receptor 7D4 is a protein that in humans is encoded by the OR7D4 gene.[1][2][3][4][5][6][7]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]

Ligands

References

  1. ↑ 1.0 1.1 "Entrez Gene: OR7D4 olfactory receptor, family 7, subfamily D, member 4". Retrieved 2013-12-17.
  2. ↑ Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
  3. ↑ Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
  4. ↑ Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H (September 2007). "Genetic variation in a human odorant receptor alters odour perception". Nature. 449 (7161): 468–72. doi:10.1038/nature06162. PMID 17873857.
  5. ↑ OR7D4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
  6. ↑ Lunde K, Egelandsdal B, Skuterud E, Mainland JD, Lea T, Hersleth M, Matsunami H (2012). Behrens M, ed. "Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone". PLOS One. 7 (5): e35259. doi:10.1371/journal.pone.0035259. PMC 3342276. PMID 22567099.
  7. ↑ Wysocki CJ, Beauchamp GK (August 1984). "Ability to smell androstenone is genetically determined". Proceedings of the National Academy of Sciences of the United States of America. 81 (15): 4899–902. doi:10.1073/pnas.81.15.4899. PMC 391599. PMID 6589634.
  8. ↑ Hornung J, Noack H, Thomas M, Farger G, Nieratschker V, Freiherr J, Derntl B (February 2018). "Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction". Hormones and Behavior. 98: 45–54. doi:10.1016/j.yhbeh.2017.12.003. PMID 29246659.
  9. ↑ de March CA, Topin J, Bruguera E, Novikov G, Ikegami K, Matsunami H, Golebiowski J (April 2018). "Odorant Receptor 7D4 Activation Dynamics". Angewandte Chemie. 57 (17): 4554–4558. doi:10.1002/anie.201713065. PMID 29462498.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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