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{{Infobox_gene}}
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'''Olfactory receptor 5AN1''' is a [[protein]] that in humans is encoded by the ''OR5AN1'' [[gene]].<ref name="entrez"/>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Olfactory receptor, family 5, subfamily AN, member 1
| HGNCid = 15255
| Symbol = OR5AN1
| AltSymbols =; OR11-244
| OMIM = 
| ECnumber = 
| Homologene = 45029
| MGIid = 3031267
| GeneAtlas_image1 = PBB_GE_OR5AN1_gnf1h02107_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 390195
    | Hs_Ensembl = ENSG00000176495
    | Hs_RefseqProtein = NP_001004729
    | Hs_RefseqmRNA = NM_001004729
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 58888508
    | Hs_GenLoc_end = 58889443
    | Hs_Uniprot = Q8NGI8
    | Mm_EntrezGene = 258680
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_146685
    | Mm_RefseqProtein = NP_666896
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
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'''Olfactory receptor, family 5, subfamily AN, member 1''', also known as '''OR5AN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR5AN1 olfactory receptor, family 5, subfamily AN, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=390195| accessdate = }}</ref>


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{{PBB_Summary
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| section_title =  
| section_title =  
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR5AN1 olfactory receptor, family 5, subfamily AN, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=390195| accessdate = }}</ref>
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR5AN1 olfactory receptor, family 5, subfamily AN, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=390195| accessdate = }}</ref>
}}
}}
==Ligands==
* [[Civetone]]
* [[Muscone]] <ref name=Ahmed>{{cite journal |author=Ahmed, L.|title=Molecular Mechanism of Activation of Human Musk Receptors OR5AN1 and OR1A1 by (R)-Muscone and Diverse Other Musk-smelling Compounds|journal=[[Proc. Natl. Acad. Sci. USA]] |volume=115|issue=17| pages=E3950–E3958|year=2018|doi=10.1073/pnas.1713026115|pmid=29632183|display-authors=etal}}</ref>


==See also==
==See also==
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
*{{cite journal  | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993 }}
}}
}}
{{refend}}
{{refend}}
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{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{Olfactory receptors}}
{{Olfactory receptors}}
[[Category:G protein coupled receptors]]
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[[Category:Olfactory receptors]]
 
 
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Latest revision as of 18:13, 3 November 2018

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Identifiers
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External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Olfactory receptor 5AN1 is a protein that in humans is encoded by the OR5AN1 gene.[1]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]

Ligands

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: OR5AN1 olfactory receptor, family 5, subfamily AN, member 1".
  2. ↑ Ahmed, L.; et al. (2018). "Molecular Mechanism of Activation of Human Musk Receptors OR5AN1 and OR1A1 by (R)-Muscone and Diverse Other Musk-smelling Compounds". Proc. Natl. Acad. Sci. USA. 115 (17): E3950–E3958. doi:10.1073/pnas.1713026115. PMID 29632183.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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