MOS (gene): Difference between revisions

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{{Infobox_gene}}
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'''Proto-oncogene serine/threonine-protein kinase mos''' is an [[enzyme]] that in humans is encoded by the ''MOS'' [[gene]].<ref name="pmid9552420">{{cite journal |vauthors=Singh B, Arlinghaus RB | title = Mos and the cell cycle | journal = Prog Cell Cycle Res | volume = 3 | issue =  | pages = 251–9 |date=May 1998 | pmid = 9552420 | pmc =  | doi 10.1007/978-1-4615-5371-7_20}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MOS v-mos Moloney murine sarcoma viral oncogene homolog| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4342| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = V-mos Moloney murine sarcoma viral oncogene homolog
| HGNCid = 7199
| Symbol = MOS
| AltSymbols =; MGC119962; MGC119963; MSV
| OMIM = 190060
| ECnumber = 
| Homologene = 3919
| MGIid = 97052
| GeneAtlas_image1 = PBB_GE_MOS_221367_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4342
    | Hs_Ensembl = ENSG00000172680
    | Hs_RefseqProtein = NP_005363
    | Hs_RefseqmRNA = NM_005372
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 57188055
    | Hs_GenLoc_end = 57189095
    | Hs_Uniprot = P00540
    | Mm_EntrezGene = 17451
    | Mm_Ensembl =   
    | Mm_RefseqmRNA = XM_973427
    | Mm_RefseqProtein = XP_978521
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''V-mos Moloney murine sarcoma viral oncogene homolog''', also known as '''MOS''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MOS v-mos Moloney murine sarcoma viral oncogene homolog| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4342| accessdate = }}</ref>


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==Interactions==
MOS (gene) has been shown to [[Protein-protein interaction|interact]] with [[MyoD]].<ref name=pmid9001211>{{cite journal |last=Lenormand |first=J L |authorlink= |author2=Benayoun B |author3=Guillier M |author4=Vandromme M |author5=Leibovitch M P |author6=Leibovitch S A  |date=Feb 1997 |title=Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins |journal=Mol. Cell. Biol. |volume=17 |issue=2 |pages=584–93 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 9001211 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=231783 | doi=10.1128/mcb.17.2.584}}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Sagata N |title=What does Mos do in oocytes and somatic cells? |journal=Bioessays |volume=19 |issue= 1 |pages= 13-21 |year= 1997 |pmid= 9008413 |doi= 10.1002/bies.950190105 }}
*{{cite journal  | author=Sagata N |title=What does Mos do in oocytes and somatic cells? |journal=BioEssays |volume=19 |issue= 1 |pages= 13–21 |year= 1997 |pmid= 9008413 |doi= 10.1002/bies.950190105 }}
*{{cite journal | author=Singh B, Arlinghaus RB |title=Mos and the cell cycle. |journal=Progress in cell cycle research |volume=3 |issue=  |pages= 251-9 |year= 1998 |pmid= 9552420 |doi=  }}
*{{cite journal   |vauthors=Caubet JF, Mathieu-Mahul D, Bernheim A, etal |title=Human proto-oncogene c-mos maps to 8q11. |journal=EMBO J. |volume=4 |issue= 9 |pages= 2245–8 |year= 1986 |pmid= 3000766 |doi= | pmc=554492 }}
*{{cite journal  | author=Caubet JF, Mathieu-Mahul D, Bernheim A, ''et al.'' |title=Human proto-oncogene c-mos maps to 8q11. |journal=EMBO J. |volume=4 |issue= 9 |pages= 2245-8 |year= 1986 |pmid= 3000766 |doi=  }}
*{{cite journal  |vauthors=Watson R, Oskarsson M, Vande Woude GF |title=Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=79 |issue= 13 |pages= 4078–82 |year= 1982 |pmid= 6287464 |doi=10.1073/pnas.79.13.4078 | pmc=346580  |bibcode=1982PNAS...79.4078W }}
*{{cite journal  | author=Watson R, Oskarsson M, Vande Woude GF |title=Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=79 |issue= 13 |pages= 4078-82 |year= 1982 |pmid= 6287464 |doi=  }}
*{{cite journal  |vauthors=Heikinheimo O, Lanzendorf SE, Baka SG, Gibbons WE |title=Cell cycle genes c-mos and cyclin-B1 are expressed in a specific pattern in human oocytes and preimplantation embryos. |journal=Hum. Reprod. |volume=10 |issue= 3 |pages= 699–707 |year= 1995 |pmid= 7540181 |doi=  }}
*{{cite journal  | author=Heikinheimo O, Lanzendorf SE, Baka SG, Gibbons WE |title=Cell cycle genes c-mos and cyclin-B1 are expressed in a specific pattern in human oocytes and preimplantation embryos. |journal=Hum. Reprod. |volume=10 |issue= 3 |pages= 699-707 |year= 1995 |pmid= 7540181 |doi=  }}
*{{cite journal   |vauthors=Lenormand JL, Benayoun B, Guillier M, etal |title=Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins. |journal=Mol. Cell. Biol. |volume=17 |issue= 2 |pages= 584–93 |year= 1997 |pmid= 9001211 |doi= 10.1128/mcb.17.2.584| pmc=231783 }}
*{{cite journal | author=Lenormand JL, Benayoun B, Guillier M, ''et al.'' |title=Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins. |journal=Mol. Cell. Biol. |volume=17 |issue= 2 |pages= 584-93 |year= 1997 |pmid= 9001211 |doi=  }}
*{{cite journal   |vauthors=Liu H, Vuyyuru VB, Pham CD, etal |title=Evidence of an interaction between Mos and Hsp70: a role of the Mos residue serine 3 in mediating Hsp70 association. |journal=Oncogene |volume=18 |issue= 23 |pages= 3461–70 |year= 1999 |pmid= 10376524 |doi= 10.1038/sj.onc.1202699 }}
*{{cite journal | author=Liu H, Vuyyuru VB, Pham CD, ''et al.'' |title=Evidence of an interaction between Mos and Hsp70: a role of the Mos residue serine 3 in mediating Hsp70 association. |journal=Oncogene |volume=18 |issue= 23 |pages= 3461-70 |year= 1999 |pmid= 10376524 |doi= 10.1038/sj.onc.1202699 }}
*{{cite journal   |vauthors=Pham CD, Vuyyuru VB, Yang Y, etal |title=Evidence for an important role of serine 16 and its phosphorylation in the stabilization of c-Mos. |journal=Oncogene |volume=18 |issue= 30 |pages= 4287–94 |year= 1999 |pmid= 10439036 |doi= 10.1038/sj.onc.1202804 }}
*{{cite journal | author=Pham CD, Vuyyuru VB, Yang Y, ''et al.'' |title=Evidence for an important role of serine 16 and its phosphorylation in the stabilization of c-Mos. |journal=Oncogene |volume=18 |issue= 30 |pages= 4287-94 |year= 1999 |pmid= 10439036 |doi= 10.1038/sj.onc.1202804 }}
*{{cite journal  |vauthors=Proikas-Cezanne T, Stabel S, Riethmacher D |title=Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos. |journal=BMC Biochem. |volume=3|pages= 6 |year= 2002 |pmid= 12022922 |doi=10.1186/1471-2091-3-6  | pmc=102758 }}
*{{cite journal  | author=Proikas-Cezanne T, Stabel S, Riethmacher D |title=Identification of protein tyrosine phosphatase 1B and casein as substrates for 124-v-Mos. |journal=BMC Biochem. |volume=3 |issue=  |pages= 6 |year= 2002 |pmid= 12022922 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Hassel S, Eichner A, Yakymovych M, etal |title=Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. |journal=Proteomics |volume=4 |issue= 5 |pages= 1346–58 |year= 2004 |pmid= 15188402 |doi= 10.1002/pmic.200300770 }}
*{{cite journal | author=Hassel S, Eichner A, Yakymovych M, ''et al.'' |title=Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry. |journal=Proteomics |volume=4 |issue= 5 |pages= 1346-58 |year= 2004 |pmid= 15188402 |doi= 10.1002/pmic.200300770 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Kalejs M, Ivanov A, Plakhins G, etal |title=Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe. |journal=BMC Cancer |volume=6|pages= 6 |year= 2006 |pmid= 16401344 |doi= 10.1186/1471-2407-6-6 | pmc=1351196 }}
*{{cite journal | author=Kalejs M, Ivanov A, Plakhins G, ''et al.'' |title=Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe. |journal=BMC Cancer |volume=6 |issue=  |pages= 6 |year= 2006 |pmid= 16401344 |doi= 10.1186/1471-2407-6-6 }}
}}
}}
{{refend}}
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Latest revision as of 08:43, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Proto-oncogene serine/threonine-protein kinase mos is an enzyme that in humans is encoded by the MOS gene.[1][2]


Interactions

MOS (gene) has been shown to interact with MyoD.[3]

References

  1. Singh B, Arlinghaus RB (May 1998). "Mos and the cell cycle". Prog Cell Cycle Res. 3: 251–9. doi:10.1007/978-1-4615-5371-7_20. PMID 9552420.
  2. "Entrez Gene: MOS v-mos Moloney murine sarcoma viral oncogene homolog".
  3. Lenormand, J L; Benayoun B; Guillier M; Vandromme M; Leibovitch M P; Leibovitch S A (Feb 1997). "Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins". Mol. Cell. Biol. UNITED STATES. 17 (2): 584–93. doi:10.1128/mcb.17.2.584. ISSN 0270-7306. PMC 231783. PMID 9001211.

Further reading