RGS19: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (1 revision imported)
 
(2 intermediate revisions by 2 users not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Regulator of G-protein signaling 19''' is a [[protein]] that in humans is encoded by the ''RGS19'' [[gene]].<ref name="pmid8524874">{{cite journal |vauthors=De Vries L, Mousli M, Wurmser A, Farquhar MG | title = GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain | journal = Proc Natl Acad Sci U S A | volume = 92 | issue = 25 | pages = 11916–20 |date=January 1996 | pmid = 8524874 | pmc = 40514 | doi =10.1073/pnas.92.25.11916 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RGS19 regulator of G-protein signalling 19| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10287| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RGS19_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1cmz.
| PDB = {{PDB2|1cmz}}
| Name = Regulator of G-protein signalling 19
| HGNCid = 13735
| Symbol = RGS19
| AltSymbols =; GAIP; RGSGAIP
| OMIM = 605071
| ECnumber = 
| Homologene = 23320
| MGIid = 1915153
| GeneAtlas_image1 = PBB_GE_RGS19_204336_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005096 |text = GTPase activator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0005834 |text = heterotrimeric G-protein complex}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006914 |text = autophagy}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}} {{GNF_GO|id=GO:0009968 |text = negative regulation of signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10287
    | Hs_Ensembl = ENSG00000171700
    | Hs_RefseqProtein = NP_001034556
    | Hs_RefseqmRNA = NM_001039467
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 62174981
    | Hs_GenLoc_end = 62181767
    | Hs_Uniprot = P49795
    | Mm_EntrezGene = 56470
    | Mm_Ensembl = ENSMUSG00000002458
    | Mm_RefseqmRNA = XM_990290
    | Mm_RefseqProtein = XP_995384
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 181617829
    | Mm_GenLoc_end = 181623330
    | Mm_Uniprot = Q78NN4
  }}
}}
'''Regulator of G-protein signalling 19''', also known as '''RGS19''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RGS19 regulator of G-protein signalling 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10287| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =
| summary_text = G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling.<ref name="entrez">{{cite web | title = Entrez Gene: RGS19 regulator of G-protein signalling 19| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10287| accessdate = }}</ref>
| summary_text = G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling.<ref name="entrez" /><ref>{{cite journal  |vauthors=Berman DM, Wilkie TM, Gilman AG |title=GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits |journal=Cell |volume=86 |issue= 3 |pages= 445–452 |year= 1996 |pmid= 8756726 |doi=10.1016/S0092-8674(00)80117-8  }}</ref>
}}
}}
==Interactions==
RGS19 has been shown to [[Protein-protein interaction|interact]] with [[GNAO1]],<ref name=pmid8986788>{{cite journal |last=De Vries |first=L |authorlink= |author2=Elenko E |author3=Hubler L |author4=Jones T L |author5=Farquhar M G  |date=Dec 1996 |title=GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=93 |issue=26 |pages=15203–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8986788 | bibcode =1996PNAS...9315203D | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.93.26.15203 |pmc=26381 }}</ref><ref name=pmid10364213>{{cite journal |last=Woulfe |first=D S |authorlink= |author2=Stadel J M  |date=June 1999 |title=Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP |journal=J. Biol. Chem. |volume=274 |issue=25 |pages=17718–24 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10364213 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.274.25.17718 }}</ref> [[GIPC1]],<ref name=pmid11251075>{{cite journal |last=Lou |first=X |authorlink= |author2=Yano H |author3=Lee F |author4=Chao M V |author5=Farquhar M G  |date=March 2001 |title=GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways |journal=Mol. Biol. Cell |volume=12 |issue=3 |pages=615–27 |publisher= |location = United States| issn = 1059-1524| pmid = 11251075 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=30968 | doi=10.1091/mbc.12.3.615}}</ref> [[OSTM1]],<ref name=pmid12826607>{{cite journal |last=Fischer |first=Thierry |authorlink= |author2=De Vries Luc |author3=Meerloo Timo |author4=Farquhar Marilyn Gist  |date=July 2003 |title=Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=100 |issue=14 |pages=8270–5 |publisher= |location = United States| issn = 0027-8424| pmid = 12826607 |doi = 10.1073/pnas.1432965100 | bibcode =2003PNAS..100.8270F | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=166218 }}</ref> [[GNAI1]],<ref name=pmid8986788/><ref name=pmid10364213/> [[GNAI3]]<ref name=pmid8524874 /><ref name=pmid8986788/><ref name=pmid10364213/> and [[GNAZ]].<ref name=pmid8986788/><ref name=pmid10906137>{{cite journal |last=Fan |first=X |authorlink= |author2=Brass L F |author3=Poncz M |author4=Spitz F |author5=Maire P |author6=Manning D R  |date=October 2000 |title=The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins |journal=J. Biol. Chem. |volume=275 |issue=41 |pages=32129–34 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10906137 |doi = 10.1074/jbc.M004577200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{Reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal  | author=De Vries L, Mousli M, Wurmser A, Farquhar MG |title=GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 25 |pages= 11916-20 |year= 1996 |pmid= 8524874 |doi=  }}
*{{cite journal  |vauthors=Berman DM, Wilkie TM, Gilman AG |title=GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits |journal=Cell |volume=86 |issue= 3 |pages= 445–452 |year= 1996 |pmid= 8756726 |doi=10.1016/S0092-8674(00)80117-8 }}
*{{cite journal | author=De Vries L, Elenko E, Hubler L, ''et al.'' |title=GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 26 |pages= 15203-8 |year= 1997 |pmid= 8986788 |doi= }}
*{{cite journal   |vauthors=De Vries L, Elenko E, Hubler L, etal |title=GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 26 |pages= 15203–8 |year= 1997 |pmid= 8986788 |doi=10.1073/pnas.93.26.15203  | pmc=26381  |bibcode=1996PNAS...9315203D }}
*{{cite journal  | author=Ogier-Denis E, Petiot A, Bauvy C, Codogno P |title=Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24599-603 |year= 1997 |pmid= 9305927 |doi= }}
*{{cite journal  |vauthors=Ogier-Denis E, Petiot A, Bauvy C, Codogno P |title=Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24599–603 |year= 1997 |pmid= 9305927 |doi=10.1074/jbc.272.39.24599  }}
*{{cite journal | author=De Vries L, Elenko E, McCaffery JM, ''et al.'' |title=RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G proteins, is located on clathrin-coated vesicles. |journal=Mol. Biol. Cell |volume=9 |issue= 5 |pages= 1123-34 |year= 1998 |pmid= 9571244 |doi=  }}
*{{cite journal   |vauthors=De Vries L, Elenko E, McCaffery JM, etal |title=RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G proteins, is located on clathrin-coated vesicles |journal=Mol. Biol. Cell |volume=9 |issue= 5 |pages= 1123–34 |year= 1998 |pmid= 9571244 |doi=  10.1091/mbc.9.5.1123| pmc=25334  }}
*{{cite journal  | author=Wang J, Ducret A, Tu Y, ''et al.'' |title=RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily. |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 26014-25 |year= 1998 |pmid= 9748280 |doi= }}
*{{cite journal  |vauthors=Popov S, Yu K, Kozasa T, Wilkie TM |title= The regulators of G protein signaling (RGS) domains of RGS4, RGS10 and GAIP retain GTPase activating protein activity in vitro
*{{cite journal | author=De Vries L, Lou X, Zhao G, ''et al.'' |title=GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 21 |pages= 12340-5 |year= 1998 |pmid= 9770488 |doi=  }}
|journal= Proc Natl Acad Sci USA
*{{cite journal | author=Fischer T, Elenko E, McCaffery JM, ''et al.'' |title=Clathrin-coated vesicles bearing GAIP possess GTPase-activating protein activity in vitro. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6722-7 |year= 1999 |pmid= 10359779 |doi= }}
|volume=94
*{{cite journal | author=Woulfe DS, Stadel JM |title=Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP. |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17718-24 |year= 1999 |pmid= 10364213 |doi=  }}
|issue=14
*{{cite journal  | author=de Alba E, De Vries L, Farquhar MG, Tjandra N |title=Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling. |journal=J. Mol. Biol. |volume=291 |issue= 4 |pages= 927-39 |year= 1999 |pmid= 10452897 |doi= 10.1006/jmbi.1999.2989 }}
|pages= 7216–20
*{{cite journal  | author=Zheng B, Chen D, Farquhar MG |title=MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 3999-4004 |year= 2000 |pmid= 10760272 |doi= }}
|year= 1997
*{{cite journal  | author=Fischer T, Elenko E, Wan L, ''et al.'' |title=Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 4040-5 |year= 2000 |pmid= 10760275 |doi= }}
|pmid=9207071
*{{cite journal | author=Ogier-Denis E, Pattingre S, El Benna J, Codogno P |title=Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39090-5 |year= 2001 |pmid= 10993892 |doi= 10.1074/jbc.M006198200 }}
  |doi=10.1073/pnas.94.14.7216
*{{cite journal  | author=Ito E, Xie G, Maruyama K, Palmer PP |title=A core-promoter region functions bi-directionally for human opioid-receptor-like gene ORL1 and its 5'-adjacent gene GAIP. |journal=J. Mol. Biol. |volume=304 |issue= 3 |pages= 259-70 |year= 2000 |pmid= 11090272 |doi= 10.1006/jmbi.2000.4212 }}
  |pmc=23796|bibcode=1997PNAS...94.7216P}}
*{{cite journal  | author=Lou X, Yano H, Lee F, ''et al.'' |title=GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways. |journal=Mol. Biol. Cell |volume=12 |issue= 3 |pages= 615-27 |year= 2001 |pmid= 11251075 |doi= }}
*{{cite journal   |vauthors=Wang J, Ducret A, Tu Y, etal |title=RGSZ1, a Gz-selective RGS protein in brain. Structure, membrane association, regulation by Galphaz phosphorylation, and relationship to a Gz gtpase-activating protein subfamily |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 26014–25 |year= 1998 |pmid= 9748280 |doi=10.1074/jbc.273.40.26014 }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal   |vauthors=De Vries L, Lou X, Zhao G, etal |title=GIPC, a PDZ domain containing protein, interacts specifically with the C terminus of RGS-GAIP |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 21 |pages= 12340–5 |year= 1998 |pmid= 9770488 |doi=10.1073/pnas.95.21.12340  | pmc=22833  |bibcode=1998PNAS...9512340D }}
*{{cite journal | author=Sierra DA, Gilbert DJ, Householder D, ''et al.'' |title=Evolution of the regulators of G-protein signaling multigene family in mouse and human. |journal=Genomics |volume=79 |issue= 2 |pages= 177-85 |year= 2002 |pmid= 11829488 |doi= 10.1006/geno.2002.6693 }}
*{{cite journal   |vauthors=Fischer T, Elenko E, McCaffery JM, etal |title=Clathrin-coated vesicles bearing GAIP possess GTPase-activating protein activity in vitro |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6722–7 |year= 1999 |pmid= 10359779 |doi=10.1073/pnas.96.12.6722 | pmc=21982  |bibcode=1999PNAS...96.6722F }}
*{{cite journal  | author=Kirikoshi H, Katoh M |title=Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors. |journal=Int. J. Mol. Med. |volume=9 |issue= 5 |pages= 509-13 |year= 2002 |pmid= 11956658 |doi= }}
*{{cite journal  |vauthors=Woulfe DS, Stadel JM |title=Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP |journal=J. Biol. Chem. |volume=274 |issue= 25 |pages= 17718–24 |year= 1999 |pmid= 10364213 |doi=10.1074/jbc.274.25.17718  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=de Alba E, De Vries L, Farquhar MG, Tjandra N |title=Solution structure of human GAIP (Galpha interacting protein): a regulator of G protein signaling |journal=J. Mol. Biol. |volume=291 |issue= 4 |pages= 927–39 |year= 1999 |pmid= 10452897 |doi= 10.1006/jmbi.1999.2989 }}
*{{cite journal  | author=Xie GX, Han X, Ito E, ''et al.'' |title=Gene structure, dual-promoters and mRNA alternative splicing of the human and mouse regulator of G protein signaling GAIP/RGS19. |journal=J. Mol. Biol. |volume=325 |issue= 4 |pages= 721-32 |year= 2003 |pmid= 12507475 |doi=  }}
*{{cite journal  |vauthors=Zheng B, Chen D, Farquhar MG |title=MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 3999–4004 |year= 2000 |pmid= 10760272 |doi=10.1073/pnas.97.8.3999  | pmc=18131  |bibcode=2000PNAS...97.3999Z }}
*{{cite journal | author=Fischer T, De Vries L, Meerloo T, Farquhar MG |title=Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8270-5 |year= 2003 |pmid= 12826607 |doi= 10.1073/pnas.1432965100 }}
*{{cite journal   |vauthors=Fischer T, Elenko E, Wan L, etal |title=Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 8 |pages= 4040–5 |year= 2000 |pmid= 10760275 |doi=10.1073/pnas.97.8.4040  | pmc=18141  |bibcode=2000PNAS...97.4040F }}
*{{cite journal  |vauthors=Ogier-Denis E, Pattingre S, El Benna J, Codogno P |title=Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells |journal=J. Biol. Chem. |volume=275 |issue= 50 |pages= 39090–5 |year= 2001 |pmid= 10993892 |doi= 10.1074/jbc.M006198200 }}
*{{cite journal  |vauthors=Ito E, Xie G, Maruyama K, Palmer PP |title=A core-promoter region functions bi-directionally for human opioid-receptor-like gene ORL1 and its 5'-adjacent gene GAIP |journal=J. Mol. Biol. |volume=304 |issue= 3 |pages= 259–70 |year= 2000 |pmid= 11090272 |doi= 10.1006/jmbi.2000.4212 }}
*{{cite journal   |vauthors=Lou X, Yano H, Lee F, etal |title=GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways |journal=Mol. Biol. Cell |volume=12 |issue= 3 |pages= 615–27 |year= 2001 |pmid= 11251075 |doi= 10.1091/mbc.12.3.615| pmc=30968  }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |bibcode=2001Natur.414..865D }}
*{{cite journal  |vauthors=Ross EM, Wilkie TM |title=GTPase-activating proteins for heterotrimeric G proteins:  regulators of G protein signaling (RGS) and RGS-like proteins |journal=Annual Review of Biochemistry |volume=69 |pages=795–827 |year= 2000 |pmid= 10966476 |doi=10.1146/annurev.biochem.69.1.795}}  
*{{cite journal  |vauthors=Sierra DA, Gilbert DJ, Householder D, Grishin NV, Yu K, Ukidwe P, Barker SA, He W, Wensel TG, Otero G, Brown G, Copeland NG, Jenkins NA, Wilkie TM |title=Evolution of the regulators of G-protein signaling multigene family in mouse and human |journal=Genomics |volume=79 |issue=2 |pages=177–85 |year=2002 |pmid=11829488 |doi=10.1006/geno.2002.6693 }}
*{{cite journal  |vauthors=Kirikoshi H, Katoh M |title=Expression of human GIPC1 in normal tissues, cancer cell lines, and primary tumors |journal=Int. J. Mol. Med. |volume=9 |issue= 5 |pages= 509–13 |year= 2002 |pmid= 11956658 |doi=  10.3892/ijmm.9.5.509}}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  |vauthors=Xie GX, Han X, Ito E, etal |title=Gene structure, dual-promoters and mRNA alternative splicing of the human and mouse regulator of G protein signaling GAIP/RGS19 |journal=J. Mol. Biol. |volume=325 |issue= 4 |pages= 721–32 |year= 2003 |pmid= 12507475 |doi=10.1016/S0022-2836(02)01283-4  }}
*{{cite journal  |vauthors=Fischer T, De Vries L, Meerloo T, Farquhar MG |title=Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 14 |pages= 8270–5 |year= 2003 |pmid= 12826607 |doi= 10.1073/pnas.1432965100 | pmc=166218 |bibcode=2003PNAS..100.8270F }}
}}
}}
{{refend}}
{{Refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|RGS19}}
* {{UCSC gene details|RGS19}}
 
{{PDB Gallery|geneid=10287}}
 
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}

Latest revision as of 07:16, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Regulator of G-protein signaling 19 is a protein that in humans is encoded by the RGS19 gene.[1][2]

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling.[2][3]

Interactions

RGS19 has been shown to interact with GNAO1,[4][5] GIPC1,[6] OSTM1,[7] GNAI1,[4][5] GNAI3[1][4][5] and GNAZ.[4][8]

References

  1. ↑ 1.0 1.1 De Vries L, Mousli M, Wurmser A, Farquhar MG (January 1996). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proc Natl Acad Sci U S A. 92 (25): 11916–20. doi:10.1073/pnas.92.25.11916. PMC 40514. PMID 8524874.
  2. ↑ 2.0 2.1 "Entrez Gene: RGS19 regulator of G-protein signalling 19".
  3. ↑ Berman DM, Wilkie TM, Gilman AG (1996). "GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits". Cell. 86 (3): 445–452. doi:10.1016/S0092-8674(00)80117-8. PMID 8756726.
  4. ↑ 4.0 4.1 4.2 4.3 De Vries, L; Elenko E; Hubler L; Jones T L; Farquhar M G (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 93 (26): 15203–8. Bibcode:1996PNAS...9315203D. doi:10.1073/pnas.93.26.15203. ISSN 0027-8424. PMC 26381. PMID 8986788.
  5. ↑ 5.0 5.1 5.2 Woulfe, D S; Stadel J M (June 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". J. Biol. Chem. UNITED STATES. 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. ISSN 0021-9258. PMID 10364213.
  6. ↑ Lou, X; Yano H; Lee F; Chao M V; Farquhar M G (March 2001). "GIPC and GAIP form a complex with TrkA: a putative link between G protein and receptor tyrosine kinase pathways". Mol. Biol. Cell. United States. 12 (3): 615–27. doi:10.1091/mbc.12.3.615. ISSN 1059-1524. PMC 30968. PMID 11251075.
  7. ↑ Fischer, Thierry; De Vries Luc; Meerloo Timo; Farquhar Marilyn Gist (July 2003). "Promotion of G alpha i3 subunit down-regulation by GIPN, a putative E3 ubiquitin ligase that interacts with RGS-GAIP". Proc. Natl. Acad. Sci. U.S.A. United States. 100 (14): 8270–5. Bibcode:2003PNAS..100.8270F. doi:10.1073/pnas.1432965100. ISSN 0027-8424. PMC 166218. PMID 12826607.
  8. ↑ Fan, X; Brass L F; Poncz M; Spitz F; Maire P; Manning D R (October 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. UNITED STATES. 275 (41): 32129–34. doi:10.1074/jbc.M004577200. ISSN 0021-9258. PMID 10906137.

Further reading

External links


Retrieved from "https://www.wikidoc.org/index.php?title=RGS19&oldid=1522153"