Amnionless: Difference between revisions

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*{{cite journal  |vauthors=Tanner SM, Aminoff M, Wright FA |title=Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia. |journal=Nat. Genet. |volume=33 |issue= 3 |pages= 426–9 |year= 2003 |pmid= 12590260 |doi= 10.1038/ng1098 |display-authors=etal}}
*{{cite journal  |vauthors=Tanner SM, Aminoff M, Wright FA |title=Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia. |journal=Nat. Genet. |volume=33 |issue= 3 |pages= 426–9 |year= 2003 |pmid= 12590260 |doi= 10.1038/ng1098 |display-authors=etal}}
*{{cite journal  |vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 |display-authors=etal}}
*{{cite journal  |vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 |display-authors=etal}}
*{{cite journal  |vauthors=Fyfe JC, Madsen M, Højrup P |title=The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. |journal=Blood |volume=103 |issue= 5 |pages= 1573–9 |year= 2004 |pmid= 14576052 |doi= 10.1182/blood-2003-08-2852 |display-authors=etal}}
*{{cite journal  |vauthors=Fyfe JC, Madsen M, Højrup P |title=The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless. |journal=Blood |volume=103 |issue= 5 |pages= 1573–9 |year= 2004 |pmid= 14576052 |doi= 10.1182/blood-2003-08-2852 |display-authors=etal|url=http://www.bloodjournal.org/content/bloodjournal/103/5/1573.full.pdf }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  |vauthors=Tsang HT, Connell JW, Brown SE |title=A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. |journal=Genomics |volume=88 |issue= 3 |pages= 333–46 |year= 2006 |pmid= 16730941 |doi= 10.1016/j.ygeno.2006.04.003 |display-authors=etal}}
*{{cite journal  |vauthors=Tsang HT, Connell JW, Brown SE |title=A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. |journal=Genomics |volume=88 |issue= 3 |pages= 333–46 |year= 2006 |pmid= 16730941 |doi= 10.1016/j.ygeno.2006.04.003 |display-authors=etal}}

Latest revision as of 06:30, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Amnionless is a protein that in humans is encoded by the AMN gene.[1][2]

Function

A complex of amnionless and cubilin forms the cubam receptor.

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila.[2]

References

  1. Kalantry S, Manning S, Haub O, Tomihara-Newberger C, Lee HG, Fangman J, Disteche CM, Manova K, Lacy E (Mar 2001). "The amnionless gene, essential for mouse gastrulation, encodes a visceral-endoderm-specific protein with an extracellular cysteine-rich domain". Nat Genet. 27 (4): 412–6. doi:10.1038/86912. PMID 11279523.
  2. 2.0 2.1 "Entrez Gene: AMN amnionless homolog (mouse)".

External links

Further reading