Paroxysmal nocturnal hemoglobinuria MRI: Difference between revisions

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==Overview==
==Overview==
 
MRI may be helpful in diagnosing venous thrombosis which is often associated with PNH. MRI is also useful for assessing for splenomegaly.  
There are no MRI findings associated with [disease name].
 
OR
 
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include [finding 1], [finding 2], and [finding 3].
 
OR
 
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include [complication 1], [complication 2], and [complication 3].


==MRI==
==MRI==


There are no MRI findings associated with [disease name].
There are no MRI findings associated with [PNH]. However, a MRI may be helpful in the diagnosis of complications of [PNH], which include:
*Renal cortical signal intensity loss secondary to hemosiderin accumulation in the renal cortex due to hemoglobinemia and haemoglobinuria.
* Hepatic and splenic signal intensity loss secondary to transfusional siderosis due to repeated blood transfusions.
* Intracranial thrombosis
* Splenic vein thrombosis
* Portal vein thrombosis
* Splenomegaly, which can be quantitated by MRI<ref name="pmid29774182">{{cite journal| author=Xie CL, Zhang M, Chen Y, Hu R, Tang MY, Chen TW et al.| title=Spleen and splenic vascular involvement in acute pancreatitis: an MRI study. | journal=Quant Imaging Med Surg | year= 2018 | volume= 8 | issue= 3 | pages= 291-300 | pmid=29774182 | doi=10.21037/qims.2018.03.04 | pmc=5941205 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29774182  }} </ref>


OR
[Location] MRI may be helpful in the diagnosis of [disease name]. Findings on MRI suggestive of/diagnostic of [disease name] include:
*[Finding 1]
*[Finding 2]
*[Finding 3]
OR
There are no MRI findings associated with [disease name]. However, a MRI may be helpful in the diagnosis of complications of [disease name], which include:
*[Complication 1]
*[Complication 2]
*[Complication 3]
*Renal cortical signal intensity loss (hemosiderin accumulates in the renal cortex when intravascular hemolysis results in the direct release of hemoglobin into the plasma).
*Venous thrombosis.
*Liver and spleen are usually of normal signal intensity in paroxysmal nocturnal hemoglobinuria, unless repeated transfusions have resulted in hepatic and splenic signal intensity loss owing to transfusional siderosis.


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(Images shown below are courtesy of RadsWiki)
(Images shown below are courtesy of RadsWiki)
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==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Latest revision as of 21:59, 18 December 2018

Paroxysmal nocturnal hemoglobinuria Microchapters

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Overview

Historical Perspective

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Epidemiology and Demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]; Associate Editor(s)-in-Chief:

Overview

MRI may be helpful in diagnosing venous thrombosis which is often associated with PNH. MRI is also useful for assessing for splenomegaly.

MRI

There are no MRI findings associated with [PNH]. However, a MRI may be helpful in the diagnosis of complications of [PNH], which include:

  • Renal cortical signal intensity loss secondary to hemosiderin accumulation in the renal cortex due to hemoglobinemia and haemoglobinuria.
  • Hepatic and splenic signal intensity loss secondary to transfusional siderosis due to repeated blood transfusions.
  • Intracranial thrombosis
  • Splenic vein thrombosis
  • Portal vein thrombosis
  • Splenomegaly, which can be quantitated by MRI[1]


References

  1. Xie CL, Zhang M, Chen Y, Hu R, Tang MY, Chen TW; et al. (2018). "Spleen and splenic vascular involvement in acute pancreatitis: an MRI study". Quant Imaging Med Surg. 8 (3): 291–300. doi:10.21037/qims.2018.03.04. PMC 5941205. PMID 29774182.

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