Lead poisoning diagnostic study of choice: Difference between revisions
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== Overview == | == Overview == | ||
The best and the most accurate method to diagnose [[lead poisoning]] is directly measuring the venous blood lead levels. | The best and the most accurate method to diagnose [[lead poisoning]] is directly measuring the venous blood lead levels. | ||
== Diagnostic Study of Choice == | == Diagnostic Study of Choice == | ||
== Study of choice == | |||
* [{Blood Lead Levels] is the gold standard test for the diagnosis of [[lead poisoning]]. <ref name="pmid22468050">{{cite journal| author=D'souza HS, Dsouza SA, Menezes G, Venkatesh T| title=Diagnosis, evaluation, and treatment of lead poisoning in general population. | journal=Indian J Clin Biochem | year= 2011 | volume= 26 | issue= 2 | pages= 197-201 | pmid=22468050 | doi=10.1007/s12291-011-0122-6 | pmc=3107416 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22468050 }} </ref> | * [{Blood Lead Levels] is the gold standard test for the diagnosis of [[lead poisoning]]. <ref name="pmid22468050">{{cite journal| author=D'souza HS, Dsouza SA, Menezes G, Venkatesh T| title=Diagnosis, evaluation, and treatment of lead poisoning in general population. | journal=Indian J Clin Biochem | year= 2011 | volume= 26 | issue= 2 | pages= 197-201 | pmid=22468050 | doi=10.1007/s12291-011-0122-6 | pmc=3107416 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22468050 }} </ref> | ||
* The following result of [[blood lead levels] is confirmatory of [[lead poisoning]]: | * The following result of [[blood lead levels] is confirmatory of [[lead poisoning]]: | ||
** BLL >5mcg/dL <ref name="pmid17718907">{{cite journal| author=Herman DS, Geraldine M, Venkatesh T| title=Evaluation, diagnosis, and treatment of lead poisoning in a patient with occupational lead exposure: a case presentation. | journal=J Occup Med Toxicol | year= 2007 | volume= 2 | issue= | pages= 7 | pmid=17718907 | doi=10.1186/1745-6673-2-7 | pmc=2000868 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17718907 }} </ref> | ** BLL >5mcg/dL <ref name="pmid17718907">{{cite journal| author=Herman DS, Geraldine M, Venkatesh T| title=Evaluation, diagnosis, and treatment of lead poisoning in a patient with occupational lead exposure: a case presentation. | journal=J Occup Med Toxicol | year= 2007 | volume= 2 | issue= | pages= 7 | pmid=17718907 | doi=10.1186/1745-6673-2-7 | pmc=2000868 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17718907 }} </ref> | ||
==== The comparison of various diagnostic studies for [disease name] ==== | ==== The comparison of various diagnostic studies for [disease name] ==== | ||
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* A positive venous blood lead levels >5mcg is detected in the patient, to confirm the diagnosis. | * A positive venous blood lead levels >5mcg is detected in the patient, to confirm the diagnosis. | ||
The rest of the main laboratory tests that measure lead effects are: | The rest of the main laboratory tests that measure lead effects are: | ||
*[[free erythrocyte protoporphyrin test]] | *[[free erythrocyte protoporphyrin test]] <ref name="pmid701012">{{cite journal| author=Peter F, Reynolds RG| title=Lead-erythrocyte protoporphyrin correlation in blood of exposed workers. | journal=Health Lab Sci | year= 1978 | volume= 15 | issue= 3 | pages= 144-9 | pmid=701012 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=701012 }} </ref> | ||
*[[zinc protoporphyrin test]] | *[[zinc protoporphyrin test]] | ||
*[[CBC]] with blood smear morphology | *[[CBC]] with blood smear morphology | ||
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*There are no established criteria for the diagnosis of [[lead poisoning]]. What matters in diagnosing [[lead poisoning]] is directly measuring the blood lead levels in venous blood. | *There are no established criteria for the diagnosis of [[lead poisoning]]. What matters in diagnosing [[lead poisoning]] is directly measuring the blood lead levels in venous blood. | ||
==References== | ==References== | ||
Latest revision as of 16:15, 15 August 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aksiniya Stevasarova, M.D.
Overview
The best and the most accurate method to diagnose lead poisoning is directly measuring the venous blood lead levels.
Diagnostic Study of Choice
Study of choice
- [{Blood Lead Levels] is the gold standard test for the diagnosis of lead poisoning. [1]
- The following result of [[blood lead levels] is confirmatory of lead poisoning:
- BLL >5mcg/dL [2]
The comparison of various diagnostic studies for [disease name]
| Test | Sensitivity | Specificity |
|---|---|---|
| Blood Lead Levels | 100% | 100% |
Blood Lead Levels= The best test based on the feature
Diagnostic results
The following result of direct venous blood lead levels in patients is confirmatory of lead poisoning:
- BLL >5mcg/dL
- BLL >40mcg/dL requires treatment with chelating agents
Sequence of Diagnostic Studies
The BLL test should be performed when:
- The patient presented with symptoms like abdominal pain ("lead colic"), joint/muscle aches, short-term memory problems, difficulty concentrating, irritability, anemia and nephropathy is the first step of diagnosis.
- A positive venous blood lead levels >5mcg is detected in the patient, to confirm the diagnosis.
The rest of the main laboratory tests that measure lead effects are:
- free erythrocyte protoporphyrin test [3]
- zinc protoporphyrin test
- CBC with blood smear morphology
- blood urea nitrogen
- serum creatinine
- urinalysis
Diagnostic Criteria
- There are no established criteria for the diagnosis of lead poisoning. What matters in diagnosing lead poisoning is directly measuring the blood lead levels in venous blood.
References
- ↑ D'souza HS, Dsouza SA, Menezes G, Venkatesh T (2011). "Diagnosis, evaluation, and treatment of lead poisoning in general population". Indian J Clin Biochem. 26 (2): 197–201. doi:10.1007/s12291-011-0122-6. PMC 3107416. PMID 22468050.
- ↑ Herman DS, Geraldine M, Venkatesh T (2007). "Evaluation, diagnosis, and treatment of lead poisoning in a patient with occupational lead exposure: a case presentation". J Occup Med Toxicol. 2: 7. doi:10.1186/1745-6673-2-7. PMC 2000868. PMID 17718907.
- ↑ Peter F, Reynolds RG (1978). "Lead-erythrocyte protoporphyrin correlation in blood of exposed workers". Health Lab Sci. 15 (3): 144–9. PMID 701012.