MAGEC2: Difference between revisions

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{{About|the protein||Magec (disambiguation)}}
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{{Infobox_gene}}
{{GNF_Protein_box
'''Melanoma-associated antigen C2''' is a [[protein]] that in humans is encoded by the ''MAGEC2'' [[gene]].<ref name="pmid10699956">{{cite journal |vauthors=Gure AO, Stockert E, Arden KC, Boyer AD, Viars CS, Scanlan MJ, Old LJ, Chen YT | title = CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis | journal = Int J Cancer | volume = 85 | issue = 5 | pages = 726–32 |date=Mar 2000 | pmid = 10699956 | pmc =  | doi =10.1002/(SICI)1097-0215(20000301)85:5<726::AID-IJC21>3.0.CO;2-F }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAGEC2 melanoma antigen family C, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51438| accessdate = }}</ref>
| image =
| image_source =
| PDB =
| Name = Melanoma antigen family C, 2
| HGNCid = 13574
| Symbol = MAGEC2
| AltSymbols =; CT10; HCA587; MAGEE1; MGC13377
| OMIM = 300468
| ECnumber =
| Homologene =
| MGIid =
  | GeneAtlas_image1 = PBB_GE_MAGEC2_220062_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51438
    | Hs_Ensembl = ENSG00000046774
    | Hs_RefseqProtein = NP_057333
    | Hs_RefseqmRNA = NM_016249
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 141117797
    | Hs_GenLoc_end = 141120744
    | Hs_Uniprot = Q9UBF1
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot =  
  }}
}}
'''Melanoma antigen family C, 2''', also known as '''MAGEC2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAGEC2 melanoma antigen family C, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51438| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is related to members of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the MAGEC genes are clustered on chromosome Xq26-q27.<ref name="entrez">{{cite web | title = Entrez Gene: MAGEC2 melanoma antigen family C, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51438| accessdate = }}</ref>
| summary_text = This gene is related to members of the [[MAGEC]] gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the MAGEC genes are clustered on chromosome Xq26-q27.<ref name="entrez">{{cite web | title = Entrez Gene: MAGEC2 melanoma antigen family C, 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51438| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Güre AO, Stockert E, Arden KC, ''et al.'' |title=CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis. |journal=Int. J. Cancer |volume=85 |issue= 5 |pages= 726-32 |year= 2000 |pmid= 10699956 |doi=  }}
*{{cite journal  |vauthors=Lucas S, De Plaen E, Boon T |title=MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. |journal=Int. J. Cancer |volume=87 |issue= 1 |pages= 55–60 |year= 2000 |pmid= 10861452 |doi=10.1002/1097-0215(20000701)87:1<55::AID-IJC8>3.0.CO;2-J }}
*{{cite journal  | author=Lucas S, De Plaen E, Boon T |title=MAGE-B5, MAGE-B6, MAGE-C2, and MAGE-C3: four new members of the MAGE family with tumor-specific expression. |journal=Int. J. Cancer |volume=87 |issue= 1 |pages= 55-60 |year= 2000 |pmid= 10861452 |doi=  }}
*{{cite journal   |vauthors=Sasaki M, Nakahira K, Kawano Y, etal |title=MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma. |journal=Cancer Res. |volume=61 |issue= 12 |pages= 4809–14 |year= 2001 |pmid= 11406556 |doi=  }}
*{{cite journal | author=Sasaki M, Nakahira K, Kawano Y, ''et al.'' |title=MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma. |journal=Cancer Res. |volume=61 |issue= 12 |pages= 4809-14 |year= 2001 |pmid= 11406556 |doi=  }}
*{{cite journal   |vauthors=Kawano Y, Sasaki M, Nakahira K, etal |title=Structural characterization and chromosomal localization of the MAGE-E1 gene. |journal=Gene |volume=277 |issue= 1-2 |pages= 129–37 |year= 2001 |pmid= 11602350 |doi=10.1016/S0378-1119(01)00698-9 }}
*{{cite journal | author=Kawano Y, Sasaki M, Nakahira K, ''et al.'' |title=Structural characterization and chromosomal localization of the MAGE-E1 gene. |journal=Gene |volume=277 |issue= 1-2 |pages= 129-37 |year= 2001 |pmid= 11602350 |doi=  }}
*{{cite journal   |vauthors=Wang Y, Han KJ, Pang XW, etal |title=Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. |journal=J. Immunol. |volume=169 |issue= 2 |pages= 1102–9 |year= 2002 |pmid= 12097419 |doi=  10.4049/jimmunol.169.2.1102}}
*{{cite journal | author=Wang Y, Han KJ, Pang XW, ''et al.'' |title=Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. |journal=J. Immunol. |volume=169 |issue= 2 |pages= 1102-9 |year= 2002 |pmid= 12097419 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Li B, Qian XP, Pang XW, etal |title=HCA587 antigen expression in normal tissues and cancers: correlation with tumor differentiation in hepatocellular carcinoma. |journal=Lab. Invest. |volume=83 |issue= 8 |pages= 1185–92 |year= 2003 |pmid= 12920247 |doi=10.1097/01.LAB.0000080605.73839.96 }}
*{{cite journal | author=Li B, Qian XP, Pang XW, ''et al.'' |title=HCA587 antigen expression in normal tissues and cancers: correlation with tumor differentiation in hepatocellular carcinoma. |journal=Lab. Invest. |volume=83 |issue= 8 |pages= 1185-92 |year= 2003 |pmid= 12920247 |doi=  }}
*{{cite journal   |vauthors=Ma W, Germeau C, Vigneron N, etal |title=Two new [[tumor-specific antigen]]ic peptides encoded by gene MAGE-C2 and presented to cytolytic T lymphocytes by HLA-A2. |journal=Int. J. Cancer |volume=109 |issue= 5 |pages= 698–702 |year= 2004 |pmid= 14999777 |doi= 10.1002/ijc.20038 }}
*{{cite journal | author=Ma W, Germeau C, Vigneron N, ''et al.'' |title=Two new tumor-specific antigenic peptides encoded by gene MAGE-C2 and presented to cytolytic T lymphocytes by HLA-A2. |journal=Int. J. Cancer |volume=109 |issue= 5 |pages= 698-702 |year= 2004 |pmid= 14999777 |doi= 10.1002/ijc.20038 }}
*{{cite journal   |vauthors=Wang Y, Liang Z, Yuan YH, etal |title=[Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery] |journal=Zhonghua Yi Xue Za Zhi |volume=84 |issue= 6 |pages= 464–8 |year= 2004 |pmid= 15061963 |doi=  }}
*{{cite journal | author=Wang Y, Liang Z, Yuan YH, ''et al.'' |title=[Expression of multiple cancer-testis antigen genes in non-small cell lung cancer treated by chemotherapy prior surgery] |journal=Zhonghua Yi Xue Za Zhi |volume=84 |issue= 6 |pages= 464-8 |year= 2004 |pmid= 15061963 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal   |vauthors=Godelaine D, Carrasco J, Brasseur F, etal |title=A new tumor-specific antigen encoded by MAGE-C2 and presented to cytolytic T lymphocytes by HLA-B44. |journal=Cancer Immunol. Immunother. |volume=56 |issue= 6 |pages= 753–9 |year= 2007 |pmid= 17096150 |doi= 10.1007/s00262-006-0244-5 }}
*{{cite journal | author=Godelaine D, Carrasco J, Brasseur F, ''et al.'' |title=A new tumor-specific antigen encoded by MAGE-C2 and presented to cytolytic T lymphocytes by HLA-B44. |journal=Cancer Immunol. Immunother. |volume=56 |issue= 6 |pages= 753-9 |year= 2007 |pmid= 17096150 |doi= 10.1007/s00262-006-0244-5 }}
*{{cite journal   |vauthors=Yang B, Wu J, Maddodi N, etal |title=Epigenetic control of MAGE gene expression by the KIT tyrosine kinase. |journal=J. Invest. Dermatol. |volume=127 |issue= 9 |pages= 2123–8 |year= 2007 |pmid= 17495964 |doi= 10.1038/sj.jid.5700836 }}
*{{cite journal | author=Yang B, Wu J, Maddodi N, ''et al.'' |title=Epigenetic control of MAGE gene expression by the KIT tyrosine kinase. |journal=J. Invest. Dermatol. |volume=127 |issue= 9 |pages= 2123-8 |year= 2007 |pmid= 17495964 |doi= 10.1038/sj.jid.5700836 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:01, 4 September 2017

This article is about the protein. For other uses, see Magec (disambiguation).
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Melanoma-associated antigen C2 is a protein that in humans is encoded by the MAGEC2 gene.[1][2]

This gene is related to members of the MAGEC gene family. It is not expressed in normal tissues, except for testis, and is expressed in tumors of various histological types. This gene and the MAGEC genes are clustered on chromosome Xq26-q27.[2]

References

  1. ↑ Gure AO, Stockert E, Arden KC, Boyer AD, Viars CS, Scanlan MJ, Old LJ, Chen YT (Mar 2000). "CT10: a new cancer-testis (CT) antigen homologous to CT7 and the MAGE family, identified by representational-difference analysis". Int J Cancer. 85 (5): 726–32. doi:10.1002/(SICI)1097-0215(20000301)85:5<726::AID-IJC21>3.0.CO;2-F. PMID 10699956.
  2. ↑ 2.0 2.1 "Entrez Gene: MAGEC2 melanoma antigen family C, 2".

Further reading



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