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{{about|the protein and gene|the microcontroller|ST6/ST7|Star Trek VII|Star Trek Generations|other uses}}
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{{Infobox_gene}}
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'''Suppressor of tumorigenicity protein 7''' is a [[protein]] that in humans is encoded by the ''ST7'' [[gene]].<ref name="pmid8105370">{{cite journal | vauthors = Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M | title = Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1 | journal = Molecular and Cellular Biology | volume = 13 | issue = 10 | pages = 6036–43 | date = October 1993 | pmid = 8105370 | pmc = 364663 | doi =  10.1128/mcb.13.10.6036}}</ref><ref name="pmid8938430">{{cite journal | vauthors = Zenklusen JC, Rodriguez LV, LaCava M, Wang Z, Goldstein LS, Conti CJ | title = Novel susceptibility locus for mouse hepatomas: evidence for a conserved tumor suppressor gene | journal = Genome Research | volume = 6 | issue = 11 | pages = 1070–6 | date = November 1996 | pmid = 8938430 | pmc =  | doi = 10.1101/gr.6.11.1070 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ST7 suppression of tumorigenicity 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7982| accessdate = }}</ref> ST7 [[orthologs]] <ref name="OrthoMaM">{{cite web | title = OrthoMaM phylogenetic marker: ST7 coding sequence | url = http://www.orthomam.univ-montp2.fr/orthomam/data/cds/detailMarkers/ENSG00000004866_ST7.xml }}</ref> have been identified in all [[mammals]] for which complete genome data are available.
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Suppression of tumorigenicity 7
| HGNCid = 11351
| Symbol = ST7
| AltSymbols =; DKFZp762O2113; ETS7q; FAM4A1; HELG; RAY1; SEN4; TSG7
| OMIM = 600833
| ECnumber = 
| Homologene = 10185
| MGIid = 1927450
| Function =  
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7982
    | Hs_Ensembl = ENSG00000004866
    | Hs_RefseqProtein = NP_060882
    | Hs_RefseqmRNA = NM_018412
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 116380617
    | Hs_GenLoc_end = 116657313
    | Hs_Uniprot = 
    | Mm_EntrezGene = 64213
    | Mm_Ensembl = ENSMUSG00000029534
    | Mm_RefseqmRNA = NM_022332
    | Mm_RefseqProtein = NP_071727
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 17644032
    | Mm_GenLoc_end = 17893020
    | Mm_Uniprot = 
  }}
}}
'''Suppression of tumorigenicity 7''', also known as '''ST7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ST7 suppression of tumorigenicity 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7982| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The gene for this product maps to a region on human chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The gene for this product maps to a region on chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described.<ref name="entrez">{{cite web | title = Entrez Gene: ST7 suppression of tumorigenicity 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7982| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
ST7 has been shown to [[Protein-protein interaction|interact]] with [[ITGB1BP3]]<ref name=pmid12809483>{{cite journal | vauthors = Battle MA, Maher VM, McCormick JJ | title = ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways | journal = Biochemistry | volume = 42 | issue = 24 | pages = 7270–82 | date = June 2003 | pmid = 12809483 | doi = 10.1021/bi034081y }}</ref> and [[GNB2L1]].<ref name=pmid12809483/>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Zenklusen JC, Weitzel JN, Ball HG, Conti CJ | title = Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene | journal = Oncogene | volume = 11 | issue = 2 | pages = 359–63 | date = July 1995 | pmid = 7624150 | doi =  }}
| citations =
* {{cite journal | vauthors = Zenklusen JC, Thompson JC, Troncoso P, Kagan J, Conti CJ | title = Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1 | journal = Cancer Research | volume = 54 | issue = 24 | pages = 6370–3 | date = December 1994 | pmid = 7987830 | doi =  }}
*{{cite journal | author=Zenklusen JC, Weitzel JN, Ball HG, Conti CJ |title=Allelic loss at 7q31.1 in human primary ovarian carcinomas suggests the existence of a tumor suppressor gene. |journal=Oncogene |volume=11 |issue= 2 |pages= 359-63 |year= 1995 |pmid= 7624150 |doi=  }}
* {{cite journal | vauthors = Zenklusen JC, Bièche I, Lidereau R, Conti CJ | title = (C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 91 | issue = 25 | pages = 12155–8 | date = December 1994 | pmid = 7991599 | pmc = 45395 | doi = 10.1073/pnas.91.25.12155 }}
*{{cite journal | author=Zenklusen JC, Thompson JC, Troncoso P, ''et al.'' |title=Loss of heterozygosity in human primary prostate carcinomas: a possible tumor suppressor gene at 7q31.1. |journal=Cancer Res. |volume=54 |issue= 24 |pages= 6370-3 |year= 1995 |pmid= 7987830 |doi=  }}
* {{cite journal | vauthors = Folstein SE, Mankoski RE | title = Chromosome 7q: where autism meets language disorder? | journal = American Journal of Human Genetics | volume = 67 | issue = 2 | pages = 278–81 | date = August 2000 | pmid = 10889044 | pmc = 1287175 | doi = 10.1086/303034 }}
*{{cite journal | author=Zenklusen JC, Bièche I, Lidereau R, Conti CJ |title=(C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 25 |pages= 12155-8 |year= 1995 |pmid= 7991599 |doi= }}
* {{cite journal | vauthors = Vincent JB, Herbrick JA, Gurling HM, Bolton PF, Roberts W, Scherer SW | title = Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual | journal = American Journal of Human Genetics | volume = 67 | issue = 2 | pages = 510–4 | date = August 2000 | pmid = 10889047 | pmc = 1287197 | doi = 10.1086/303005 }}
*{{cite journal  | author=Ogata T, Ayusawa D, Namba M, ''et al.'' |title=Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1. |journal=Mol. Cell. Biol. |volume=13 |issue= 10 |pages= 6036-43 |year= 1993 |pmid= 8105370 |doi=  }}
* {{cite journal | vauthors = Zenklusen JC, Conti CJ, Green ED | title = Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31 | journal = Nature Genetics | volume = 27 | issue = 4 | pages = 392–8 | date = April 2001 | pmid = 11279520 | doi = 10.1038/86891 }}
*{{cite journal | author=Zenklusen JC, Rodriguez LV, LaCava M, ''et al.'' |title=Novel susceptibility locus for mouse hepatomas: evidence for a conserved tumor suppressor gene. |journal=Genome Res. |volume=6 |issue= 11 |pages= 1070-6 |year= 1997 |pmid= 8938430 |doi=  }}
* {{cite journal | vauthors = Brown VL, Proby CM, Barnes DM, Kelsell DP | title = Lack of mutations within ST7 gene in tumour-derived cell lines and primary epithelial tumours | journal = British Journal of Cancer | volume = 87 | issue = 2 | pages = 208–11 | date = July 2002 | pmid = 12107844 | pmc = 2376116 | doi = 10.1038/sj.bjc.6600418 }}
*{{cite journal  | author=Folstein SE, Mankoski RE |title=Chromosome 7q: where autism meets language disorder? |journal=Am. J. Hum. Genet. |volume=67 |issue= 2 |pages= 278-81 |year= 2000 |pmid= 10889044 |doi= }}
* {{cite journal | vauthors = Vincent JB, Petek E, Thevarkunnel S, Kolozsvari D, Cheung J, Patel M, Scherer SW | title = The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system | journal = Genomics | volume = 80 | issue = 3 | pages = 283–94 | date = September 2002 | pmid = 12213198 | doi = 10.1006/geno.2002.6835 }}
*{{cite journal | author=Vincent JB, Herbrick JA, Gurling HM, ''et al.'' |title=Identification of a novel gene on chromosome 7q31 that is interrupted by a translocation breakpoint in an autistic individual. |journal=Am. J. Hum. Genet. |volume=67 |issue= 2 |pages= 510-4 |year= 2000 |pmid= 10889047 |doi= }}
* {{cite journal | vauthors = Dong SM, Sidransky D | title = Absence of ST7 gene alterations in human cancer | journal = Clinical Cancer Research | volume = 8 | issue = 9 | pages = 2939–41 | date = September 2002 | pmid = 12231539 | doi =  }}
*{{cite journal | author=Zenklusen JC, Conti CJ, Green ED |title=Mutational and functional analyses reveal that ST7 is a highly conserved tumor-suppressor gene on human chromosome 7q31. |journal=Nat. Genet. |volume=27 |issue= 4 |pages= 392-8 |year= 2001 |pmid= 11279520 |doi= 10.1038/86891 }}
* {{cite journal | vauthors = Wang S, Mori Y, Sato F, Yin J, Xu Y, Zou TT, Olaru A, Kimos MC, Perry K, Selaru FM, Deacu E, Sun M, Shi YC, Shibata D, Abraham JM, Greenwald BD, Meltzer SJ | title = An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma | journal = Oncogene | volume = 22 | issue = 3 | pages = 467–70 | date = January 2003 | pmid = 12545169 | doi = 10.1038/sj.onc.1206125 }}
*{{cite journal | author=Brown VL, Proby CM, Barnes DM, Kelsell DP |title=Lack of mutations within ST7 gene in tumour-derived cell lines and primary epithelial tumours. |journal=Br. J. Cancer |volume=87 |issue= 2 |pages= 208-11 |year= 2002 |pmid= 12107844 |doi= 10.1038/sj.bjc.6600418 }}
* {{cite journal | vauthors = Battle MA, Maher VM, McCormick JJ | title = ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways | journal = Biochemistry | volume = 42 | issue = 24 | pages = 7270–82 | date = June 2003 | pmid = 12809483 | doi = 10.1021/bi034081y }}
*{{cite journal | author=Vincent JB, Petek E, Thevarkunnel S, ''et al.'' |title=The RAY1/ST7 tumor-suppressor locus on chromosome 7q31 represents a complex multi-transcript system. |journal=Genomics |volume=80 |issue= 3 |pages= 283-94 |year= 2003 |pmid= 12213198 |doi= }}
* {{cite journal | vauthors = Sivasundaram K, Suzuki H, Seto M, Hosokawa Y | title = Mutational analysis of the ST7 gene in human myeloid tumor cell lines | journal = Oncology Reports | volume = 10 | issue = 6 | pages = 1737–9 | year = 2004 | pmid = 14534688 | doi = 10.3892/or.10.6.1737 }}
*{{cite journal | author=Dong SM, Sidransky D |title=Absence of ST7 gene alterations in human cancer. |journal=Clin. Cancer Res. |volume=8 |issue= 9 |pages= 2939-41 |year= 2002 |pmid= 12231539 |doi=  }}
* {{cite journal | vauthors = Lu C, Xu HM, Ren Q, Ao Y, Wang ZN, Ao X, Jiang L, Luo Y, Zhang X | title = Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC | journal = World Journal of Gastroenterology | volume = 9 | issue = 12 | pages = 2662–5 | date = December 2003 | pmid = 14669308 | doi =  10.3748/wjg.v9.i12.2662}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Liu J, Gough J, Rost B | title = Distinguishing protein-coding from non-coding RNAs through support vector machines | journal = PLoS Genetics | volume = 2 | issue = 4 | pages = e29 | date = April 2006 | pmid = 16683024 | pmc = 1449884 | doi = 10.1371/journal.pgen.0020029 }} {{open access}}
*{{cite journal  | author=Wang S, Mori Y, Sato F, ''et al.'' |title=An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma. |journal=Oncogene |volume=22 |issue= 3 |pages= 467-70 |year= 2003 |pmid= 12545169 |doi= 10.1038/sj.onc.1206125 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | author=Battle MA, Maher VM, McCormick JJ |title=ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways. |journal=Biochemistry |volume=42 |issue= 24 |pages= 7270-82 |year= 2003 |pmid= 12809483 |doi= 10.1021/bi034081y }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | author=Sivasundaram K, Suzuki H, Seto M, Hosokawa Y |title=Mutational analysis of the ST7 gene in human myeloid tumor cell lines. |journal=Oncol. Rep. |volume=10 |issue= 6 |pages= 1737-9 |year= 2004 |pmid= 14534688 |doi= }}
*{{cite journal | author=Lu C, Xu HM, Ren Q, ''et al.'' |title=Somatic mutation analysis of p53 and ST7 tumor suppressor genes in gastric carcinoma by DHPLC. |journal=World J. Gastroenterol. |volume=9 |issue= 12 |pages= 2662-5 |year= 2004 |pmid= 14669308 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Liu J, Gough J, Rost B |title=Distinguishing protein-coding from non-coding RNAs through support vector machines. |journal=PLoS Genet. |volume=2 |issue= 4 |pages= e29 |year= 2006 |pmid= 16683024 |doi= 10.1371/journal.pgen.0020029 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 11:24, 19 October 2017

This article is about the protein and gene. For the microcontroller, see ST6/ST7. For Star Trek VII, see Star Trek Generations. For other uses, see ST7 (disambiguation).
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Suppressor of tumorigenicity protein 7 is a protein that in humans is encoded by the ST7 gene.[1][2][3] ST7 orthologs [4] have been identified in all mammals for which complete genome data are available.

Function

The gene for this product maps to a region on human chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described.[3]

Interactions

ST7 has been shown to interact with ITGB1BP3[5] and GNB2L1.[5]

References

  1. ↑ Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M (October 1993). "Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1". Molecular and Cellular Biology. 13 (10): 6036–43. doi:10.1128/mcb.13.10.6036. PMC 364663. PMID 8105370.
  2. ↑ Zenklusen JC, Rodriguez LV, LaCava M, Wang Z, Goldstein LS, Conti CJ (November 1996). "Novel susceptibility locus for mouse hepatomas: evidence for a conserved tumor suppressor gene". Genome Research. 6 (11): 1070–6. doi:10.1101/gr.6.11.1070. PMID 8938430.
  3. ↑ 3.0 3.1 "Entrez Gene: ST7 suppression of tumorigenicity 7".
  4. ↑ "OrthoMaM phylogenetic marker: ST7 coding sequence".
  5. ↑ 5.0 5.1 Battle MA, Maher VM, McCormick JJ (June 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry. 42 (24): 7270–82. doi:10.1021/bi034081y. PMID 12809483.

Further reading

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