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{{Infobox_gene}}
{{PBB_Controls
'''Actin-binding LIM protein 3''' is a [[protein]] that in humans is encoded by the '''ABLIM3''' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ABLIM3 actin binding LIM protein family, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22885| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_ABLIM3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1ujs.
| PDB = {{PDB2|1ujs}}, {{PDB2|2dj7}}
| Name = Actin binding LIM protein family, member 3
| HGNCid = 29132
| Symbol = ABLIM3
| AltSymbols =; HMFN1661
| OMIM = 
| ECnumber = 
| Homologene = 69175
| MGIid = 2442582
| GeneAtlas_image1 = PBB_GE_ABLIM3_205730_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22885
    | Hs_Ensembl = ENSG00000173210
    | Hs_RefseqProtein = NP_055760
    | Hs_RefseqmRNA = NM_014945
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 148501326
    | Hs_GenLoc_end = 148620192
    | Hs_Uniprot = O94929
    | Mm_EntrezGene = 319713
    | Mm_Ensembl = ENSMUSG00000032735
    | Mm_RefseqmRNA = NM_198649
    | Mm_RefseqProtein = NP_941051
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 61926664
    | Mm_GenLoc_end = 61997085
    | Mm_Uniprot = Q69ZX8
  }}
}}
'''Actin binding LIM protein family, member 3''', also known as '''ABLIM3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ABLIM3 actin binding LIM protein family, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22885| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
The [[LIM domain]] is a double [[zinc finger]] structure that promotes [[protein-protein interaction]]s. LIM domain proteins, such as ABLIM3, play roles in [[embryonic development]], cell lineage determination, and [[cancer]].<ref>{{cite journal | vauthors = Krupp M, Weinmann A, Galle PR, Teufel A | title = Actin binding LIM protein 3 (abLIM3) | journal = International Journal of Molecular Medicine | volume = 17 | issue = 1 | date = Jan 2006 | pmid = 16328021 | doi=10.3892/ijmm.17.1.129 | pages=129–33}}</ref> An important [[paralog]] of this gene is [[LIMS1]].
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== Clinical relevance ==
{{reflist|2}}
 
==Further reading==
Diseases associated with ABLIM3 include [[hepatoblastoma]], and among its related super-pathways are [[axon guidance]] and DCC mediated attractive signaling.
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|ABLIM3}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 6 | pages = 355–64 | date = Dec 1998 | pmid = 10048485 | doi = 10.1093/dnares/5.6.355 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Nagase T, Ishikawa K, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355-64 |year= 1999 |pmid= 10048485 |doi= }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Yamada S, Ohira M, Horie H, Ando K, Takayasu H, Suzuki Y, Sugano S, Hirata T, Goto T, Matsunaga T, Hiyama E, Hayashi Y, Ando H, Suita S, Kaneko M, Sasaki F, Hashizume K, Ohnuma N, Nakagawara A | title = Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas | journal = Oncogene | volume = 23 | issue = 35 | pages = 5901–11 | date = Aug 2004 | pmid = 15221005 | doi = 10.1038/sj.onc.1207782 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Zheng B, Wen JK, Han M, Zhou AR | title = hhLIM protein is involved in cardiac hypertrophy | journal = Biochimica et Biophysica Acta | volume = 1690 | issue = 1 | pages = 1–10 | date = Sep 2004 | pmid = 15337165 | doi = 10.1016/j.bbadis.2004.04.009 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Research | volume = 14 | issue = 9 | pages = 1711–8 | date = Sep 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
*{{cite journal  | author=Yamada S, Ohira M, Horie H, ''et al.'' |title=Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. |journal=Oncogene |volume=23 |issue= 35 |pages= 5901-11 |year= 2004 |pmid= 15221005 |doi= 10.1038/sj.onc.1207782 }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = Oct 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
*{{cite journal | author=Zheng B, Wen JK, Han M, Zhou AR |title=hhLIM protein is involved in cardiac hypertrophy. |journal=Biochim. Biophys. Acta |volume=1690 |issue= 1 |pages= 1-10 |year= 2004 |pmid= 15337165 |doi= 10.1016/j.bbadis.2004.04.009 }}
* {{cite journal | vauthors = Krupp M, Weinmann A, Galle PR, Teufel A | title = Actin binding LIM protein 3 (abLIM3) | journal = International Journal of Molecular Medicine | volume = 17 | issue = 1 | pages = 129–33 | date = Jan 2006 | pmid = 16328021 | doi = 10.3892/ijmm.17.1.129 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415–8 | date = Jan 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
* {{cite journal | vauthors = Barrientos T, Frank D, Kuwahara K, Bezprozvannaya S, Pipes GC, Bassel-Duby R, Richardson JA, Katus HA, Olson EN, Frey N | title = Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin | journal = The Journal of Biological Chemistry | volume = 282 | issue = 11 | pages = 8393–403 | date = Mar 2007 | pmid = 17194709 | doi = 10.1074/jbc.M607549200 }}
*{{cite journal | author=Krupp M, Weinmann A, Galle PR, Teufel A |title=Actin binding LIM protein 3 (abLIM3). |journal=Int. J. Mol. Med. |volume=17 |issue= 1 |pages= 129-33 |year= 2006 |pmid= 16328021 |doi= }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Barrientos T, Frank D, Kuwahara K, ''et al.'' |title=Two novel members of the ABLIM protein family, ABLIM-2 and -3, associate with STARS and directly bind F-actin. |journal=J. Biol. Chem. |volume=282 |issue= 11 |pages= 8393-403 |year= 2007 |pmid= 17194709 |doi= 10.1074/jbc.M607549200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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Latest revision as of 17:41, 29 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Actin-binding LIM protein 3 is a protein that in humans is encoded by the ABLIM3 gene.[1]

Function

The LIM domain is a double zinc finger structure that promotes protein-protein interactions. LIM domain proteins, such as ABLIM3, play roles in embryonic development, cell lineage determination, and cancer.[2] An important paralog of this gene is LIMS1.

Clinical relevance

Diseases associated with ABLIM3 include hepatoblastoma, and among its related super-pathways are axon guidance and DCC mediated attractive signaling.

References

  1. ↑ "Entrez Gene: ABLIM3 actin binding LIM protein family, member 3".
  2. ↑ Krupp M, Weinmann A, Galle PR, Teufel A (Jan 2006). "Actin binding LIM protein 3 (abLIM3)". International Journal of Molecular Medicine. 17 (1): 129–33. doi:10.3892/ijmm.17.1.129. PMID 16328021.

External links

Further reading



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