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{{Infobox_gene}}
{{PBB_Controls
'''SERTA domain-containing protein 1''' is a [[protein]] that in humans is encoded by the ''SERTAD1'' [[gene]].<ref name="pmid6434876">{{cite journal | vauthors = Besley GT, Broadhead DM, Lawlor E | title = Acid esterase deficiency: comparison of biochemical findings in infantile and adult forms | journal = J Inherit Metab Dis | volume = 7 Suppl 2 | issue =  | pages = 155–6 | date = Nov 1984 | pmid = 6434876 | pmc =  | doi = 10.1007/978-94-009-5612-4_52 }}</ref><ref name="pmid10580009">{{cite journal | vauthors = Sugimoto M, Nakamura T, Ohtani N, Hampson L, Hampson IN, Shimamoto A, Furuichi Y, Okumura K, Niwa S, Taya Y, Hara E | title = Regulation of CDK4 activity by a novel CDK4-binding protein, p34SEI-1 | journal = Genes Dev | volume = 13 | issue = 22 | pages = 3027–33 | date = Jan 2000 | pmid = 10580009 | pmc = 317153 | doi = 10.1101/gad.13.22.3027 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SERTAD1 SERTA domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29950| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = SERTA domain containing 1
| HGNCid = 17932
| Symbol = SERTAD1
| AltSymbols =; SEI1; TRIP-Br1
| OMIM = 
| ECnumber = 
| Homologene = 8365
| MGIid = 1913438
| GeneAtlas_image1 = PBB_GE_SERTAD1_gnf1h00138_at_tn.png
| GeneAtlas_image2 = PBB_GE_SERTAD1_gnf1h00139_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016563 |text = transcription activator activity}}
| Component =
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0045941 |text = positive regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 29950
    | Hs_Ensembl = ENSG00000197019
    | Hs_RefseqProtein = NP_037508
    | Hs_RefseqmRNA = NM_013376
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 45619339
    | Hs_GenLoc_end = 45623772
    | Hs_Uniprot = Q9UHV2
    | Mm_EntrezGene = 55942
    | Mm_Ensembl = ENSMUSG00000008384
    | Mm_RefseqmRNA = NM_018820
    | Mm_RefseqProtein = NP_061290
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 27195670
    | Mm_GenLoc_end = 27199067
    | Mm_Uniprot = Q9JL10
  }}
}}
'''SERTA domain containing 1''', also known as '''SERTAD1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SERTAD1 SERTA domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29950| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
SERTAD1 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[CREB-binding protein]],<ref name = pmid12736710>{{cite journal | vauthors = Hirose T, Fujii R, Nakamura H, Aratani S, Fujita H, Nakazawa M, Nakamura K, Nishioka K, Nakajima T | title = Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP | journal = Int. J. Mol. Med. | volume = 11 | issue = 6 | pages = 705–12 | date = Jun 2003 | pmid = 12736710 | doi = 10.3892/ijmm.11.6.705}}</ref>
| section_title =  
* [[Cyclin-dependent kinase 4]],<ref name = pmid10580009/><ref name = pmid15065884/> and
| summary_text =  
* [[P16 (gene)|P16]].<ref name = pmid10580009 /><ref name = pmid15065884>{{cite journal | vauthors = Li J, Melvin WS, Tsai MD, Muscarella P | title = The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner | journal = Biochemistry | volume = 43 | issue = 14 | pages = 4394–9 | date = Apr 2004 | pmid = 15065884 | doi = 10.1021/bi035601s }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
| citations =
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Besley GT, Broadhead DM, Lawlor E |title=Acid esterase deficiency: comparison of biochemical findings in infantile and adult forms. |journal=J. Inherit. Metab. Dis. |volume=7 Suppl 2 |issue=  |pages= 155-6 |year= 1984 |pmid= 6434876 |doi=  }}
* {{cite journal | vauthors = Hsu SI, Yang CM, Sim KG, Hentschel DM, O'Leary E, Bonventre JV | title = TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1 | journal = EMBO J. | volume = 20 | issue = 9 | pages = 2273–85 | year = 2001 | pmid = 11331592 | pmc = 125435 | doi = 10.1093/emboj/20.9.2273 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Hirose T, Fujii R, Nakamura H, Aratani S, Fujita H, Nakazawa M, Nakamura K, Nishioka K, Nakajima T | title = Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP | journal = Int. J. Mol. Med. | volume = 11 | issue = 6 | pages = 705–12 | year = 2004 | pmid = 12736710 | doi = 10.3892/ijmm.11.6.705 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Gupta S, Takhar PP, Degenkolbe R, Koh CH, Zimmermann H, Yang CM, Guan Sim K, Hsu SI, Bernard HU | title = The human papillomavirus type 11 and 16 E6 proteins modulate the cell-cycle regulator and transcription cofactor TRIP-Br1 | journal = Virology | volume = 317 | issue = 1 | pages = 155–64 | year = 2004 | pmid = 14675634 | doi = 10.1016/j.virol.2003.08.008 }}
*{{cite journal  | author=Sugimoto M, Nakamura T, Ohtani N, ''et al.'' |title=Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). |journal=Genes Dev. |volume=13 |issue= 22 |pages= 3027-33 |year= 2000 |pmid= 10580009 |doi=  }}
* {{cite journal | vauthors = Li J, Melvin WS, Tsai MD, Muscarella P | title = The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner | journal = Biochemistry | volume = 43 | issue = 14 | pages = 4394–9 | year = 2004 | pmid = 15065884 | doi = 10.1021/bi035601s }}
*{{cite journal | author=Hsu SI, Yang CM, Sim KG, ''et al.'' |title=TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. |journal=EMBO J. |volume=20 |issue= 9 |pages= 2273-85 |year= 2001 |pmid= 11331592 |doi= 10.1093/emboj/20.9.2273 }}
* {{cite journal | vauthors = Li J, Muscarella P, Joo SH, Knobloch TJ, Melvin WS, Weghorst CM, Tsai MD | title = Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A) | journal = Biochemistry | volume = 44 | issue = 40 | pages = 13246–56 | year = 2006 | pmid = 16201750 | doi = 10.1021/bi0504658 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T | title = Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries | journal = DNA Res. | volume = 12 | issue = 2 | pages = 117–26 | year = 2007 | pmid = 16303743 | doi = 10.1093/dnares/12.2.117 }}
*{{cite journal  | author=Hirose T, Fujii R, Nakamura H, ''et al.'' |title=Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP. |journal=Int. J. Mol. Med. |volume=11 |issue= 6 |pages= 705-12 |year= 2004 |pmid= 12736710 |doi= }}
* {{cite journal | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Gupta S, Takhar PP, Degenkolbe R, ''et al.'' |title=The human papillomavirus type 11 and 16 E6 proteins modulate the cell-cycle regulator and transcription cofactor TRIP-Br1. |journal=Virology |volume=317 |issue= 1 |pages= 155-64 |year= 2004 |pmid= 14675634 |doi= }}
*{{cite journal | author=Li J, Melvin WS, Tsai MD, Muscarella P |title=The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner. |journal=Biochemistry |volume=43 |issue= 14 |pages= 4394-9 |year= 2004 |pmid= 15065884 |doi= 10.1021/bi035601s }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Li J, Muscarella P, Joo SH, ''et al.'' |title=Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A). |journal=Biochemistry |volume=44 |issue= 40 |pages= 13246-56 |year= 2006 |pmid= 16201750 |doi= 10.1021/bi0504658 }}
*{{cite journal | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
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Latest revision as of 06:09, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SERTA domain-containing protein 1 is a protein that in humans is encoded by the SERTAD1 gene.[1][2][3]

Interactions

SERTAD1 has been shown to interact with:

References

  1. ↑ Besley GT, Broadhead DM, Lawlor E (Nov 1984). "Acid esterase deficiency: comparison of biochemical findings in infantile and adult forms". J Inherit Metab Dis. 7 Suppl 2: 155–6. doi:10.1007/978-94-009-5612-4_52. PMID 6434876.
  2. ↑ 2.0 2.1 2.2 Sugimoto M, Nakamura T, Ohtani N, Hampson L, Hampson IN, Shimamoto A, Furuichi Y, Okumura K, Niwa S, Taya Y, Hara E (Jan 2000). "Regulation of CDK4 activity by a novel CDK4-binding protein, p34SEI-1". Genes Dev. 13 (22): 3027–33. doi:10.1101/gad.13.22.3027. PMC 317153. PMID 10580009.
  3. ↑ "Entrez Gene: SERTAD1 SERTA domain containing 1".
  4. ↑ Hirose T, Fujii R, Nakamura H, Aratani S, Fujita H, Nakazawa M, Nakamura K, Nishioka K, Nakajima T (Jun 2003). "Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP". Int. J. Mol. Med. 11 (6): 705–12. doi:10.3892/ijmm.11.6.705. PMID 12736710.
  5. ↑ 5.0 5.1 Li J, Melvin WS, Tsai MD, Muscarella P (Apr 2004). "The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner". Biochemistry. 43 (14): 4394–9. doi:10.1021/bi035601s. PMID 15065884.

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Hsu SI, Yang CM, Sim KG, Hentschel DM, O'Leary E, Bonventre JV (2001). "TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1". EMBO J. 20 (9): 2273–85. doi:10.1093/emboj/20.9.2273. PMC 125435. PMID 11331592.
  • Hirose T, Fujii R, Nakamura H, Aratani S, Fujita H, Nakazawa M, Nakamura K, Nishioka K, Nakajima T (2004). "Regulation of CREB-mediated transcription by association of CDK4 binding protein p34SEI-1 with CBP". Int. J. Mol. Med. 11 (6): 705–12. doi:10.3892/ijmm.11.6.705. PMID 12736710.
  • Gupta S, Takhar PP, Degenkolbe R, Koh CH, Zimmermann H, Yang CM, Guan Sim K, Hsu SI, Bernard HU (2004). "The human papillomavirus type 11 and 16 E6 proteins modulate the cell-cycle regulator and transcription cofactor TRIP-Br1". Virology. 317 (1): 155–64. doi:10.1016/j.virol.2003.08.008. PMID 14675634.
  • Li J, Melvin WS, Tsai MD, Muscarella P (2004). "The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner". Biochemistry. 43 (14): 4394–9. doi:10.1021/bi035601s. PMID 15065884.
  • Li J, Muscarella P, Joo SH, Knobloch TJ, Melvin WS, Weghorst CM, Tsai MD (2006). "Dissection of CDK4-binding and transactivation activities of p34(SEI-1) and comparison between functions of p34(SEI-1) and p16(INK4A)". Biochemistry. 44 (40): 13246–56. doi:10.1021/bi0504658. PMID 16201750.
  • Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.


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