TIMM13: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Mitochondrial import inner membrane translocase subunit Tim13''' is an [[enzyme]] that in humans is encoded by the ''TIMM13'' [[gene]].<ref name="pmid10552927">{{cite journal | vauthors = Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL | title = The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins | journal = Genomics | volume = 61 | issue = 3 | pages = 259–67 | date = Nov 1999 | pmid = 10552927 | pmc =  | doi = 10.1006/geno.1999.5966 }}</ref><ref name="pmid17329230">{{cite journal | vauthors = Gentle IE, Perry AJ, Alcock FH, Likić VA, Dolezal P, Ng ET, Purcell AW, McConnville M, Naderer T, Chanez AL, Charrière F, Aschinger C, Schneider A, Tokatlidis K, Lithgow T | title = Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space | journal = Molecular Biology and Evolution | volume = 24 | issue = 5 | pages = 1149–60 | date = May 2007 | pmid = 17329230 | pmc =  | doi = 10.1093/molbev/msm031 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26517| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Translocase of inner mitochondrial membrane 13 homolog (yeast)
| HGNCid = 11816
| Symbol = TIMM13
| AltSymbols =; TIM13; TIM13B; TIMM13A; TIMM13B; ppv1
| OMIM = 607383
| ECnumber = 
| Homologene = 40846
| MGIid = 1353432
| GeneAtlas_image1 = PBB_GE_TIMM13_218188_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005744 |text = mitochondrial inner membrane presequence translocase complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0042719 |text = mitochondrial intermembrane space protein transporter complex}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0045039 |text = protein import into mitochondrial inner membrane}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26517
    | Hs_Ensembl = ENSG00000099800
    | Hs_RefseqProtein = NP_036590
    | Hs_RefseqmRNA = NM_012458
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 2376630
    | Hs_GenLoc_end = 2378875
    | Hs_Uniprot = Q9Y5L4
    | Mm_EntrezGene = 30055
    | Mm_Ensembl = ENSMUSG00000020219
    | Mm_RefseqmRNA = NM_013895
    | Mm_RefseqProtein = NP_038923
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 80302579
    | Mm_GenLoc_end = 80303895
    | Mm_Uniprot = P62075
  }}
}}
'''Translocase of inner mitochondrial membrane 13 homolog (yeast)''', also known as '''TIMM13''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26517| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a translocase with similarity to yeast mitochondrial proteins that are involved in the import of metabolite transporters from the cytoplasm and into the mitochondrial inner membrane. The encoded protein and the TIMM8a protein form a 70 kDa complex in the intermembrane space. This gene is in a head-to-tail orientation with the gene for lamin B2.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a translocase with similarity to yeast mitochondrial proteins that are involved in the import of metabolite transporters from the cytoplasm and into the mitochondrial inner membrane. The encoded protein and the TIMM8a protein form a 70 kDa complex in the intermembrane space. This gene is in a head-to-tail orientation with the gene for lamin B2.<ref name="entrez">{{cite web | title = Entrez Gene: TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26517| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
TIMM13 has been shown to [[Protein-protein interaction|interact]] with [[TIMM8A]].<ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref><ref name=pmid11875042>{{cite journal | vauthors = Roesch K, Curran SP, Tranebjaerg L, Koehler CM | title = Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex | journal = Human Molecular Genetics | volume = 11 | issue = 5 | pages = 477–86 | date = Mar 2002 | pmid = 11875042 | doi = 10.1093/hmg/11.5.477 }}</ref>
{{refbegin | 2}}
 
{{PBB_Further_reading
== References ==
| citations =
{{reflist}}
*{{cite journal | author=Rehling P, Wiedemann N, Pfanner N, Truscott KN |title=The mitochondrial import machinery for preproteins. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=36 |issue= 3 |pages= 291-336 |year= 2001 |pmid= 11450972 |doi= }}
 
*{{cite journal | author=Paschen SA, Neupert W |title=Protein import into mitochondria. |journal=IUBMB Life |volume=52 |issue= 3-5 |pages= 101-12 |year= 2002 |pmid= 11798021 |doi= }}
== Further reading ==
*{{cite journal | author=Neupert W, Brunner M |title=The protein import motor of mitochondria. |journal=Nat. Rev. Mol. Cell Biol. |volume=3 |issue= 8 |pages= 555-65 |year= 2002 |pmid= 12154367 |doi= 10.1038/nrm878 }}
{{refbegin|33em}}
*{{cite journal | author=Jensen RE, Dunn CD |title=Protein import into and across the mitochondrial inner membrane: role of the TIM23 and TIM22 translocons. |journal=Biochim. Biophys. Acta |volume=1592 |issue= 1 |pages= 25-34 |year= 2002 |pmid= 12191765 |doi= }}
* {{cite journal | vauthors = Rehling P, Wiedemann N, Pfanner N, Truscott KN | title = The mitochondrial import machinery for preproteins | journal = Critical Reviews in Biochemistry and Molecular Biology | volume = 36 | issue = 3 | pages = 291–336 | year = 2001 | pmid = 11450972 | doi = 10.1080/20014091074200 }}
*{{cite journal  | author=Jin H, Kendall E, Freeman TC, ''et al.'' |title=The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins. |journal=Genomics |volume=61 |issue= 3 |pages= 259-67 |year= 2000 |pmid= 10552927 |doi= 10.1006/geno.1999.5966 }}
* {{cite journal | vauthors = Paschen SA, Neupert W | title = Protein import into mitochondria | journal = IUBMB Life | volume = 52 | issue = 3-5 | pages = 101–12 | year = 2002 | pmid = 11798021 | doi = 10.1080/15216540152845894 }}
*{{cite journal | author=Bauer MF, Rothbauer U, Mühlenbein N, ''et al.'' |title=The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. |journal=FEBS Lett. |volume=464 |issue= 1-2 |pages= 41-7 |year= 2000 |pmid= 10611480 |doi= }}
* {{cite journal | vauthors = Neupert W, Brunner M | title = The protein import motor of mitochondria | journal = Nature Reviews. Molecular Cell Biology | volume = 3 | issue = 8 | pages = 555–65 | date = Aug 2002 | pmid = 12154367 | doi = 10.1038/nrm878 }}
*{{cite journal | author=Paschen SA, Rothbauer U, Káldi K, ''et al.'' |title=The role of the TIM8-13 complex in the import of Tim23 into mitochondria. |journal=EMBO J. |volume=19 |issue= 23 |pages= 6392-400 |year= 2001 |pmid= 11101512 |doi= 10.1093/emboj/19.23.6392 }}
* {{cite journal | vauthors = Jensen RE, Dunn CD | title = Protein import into and across the mitochondrial inner membrane: role of the TIM23 and TIM22 translocons | journal = Biochimica et Biophysica Acta | volume = 1592 | issue = 1 | pages = 25–34 | date = Sep 2002 | pmid = 12191765 | doi = 10.1016/S0167-4889(02)00261-6 }}
*{{cite journal | author=Rothbauer U, Hofmann S, Mühlenbein N, ''et al.'' |title=Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria. |journal=J. Biol. Chem. |volume=276 |issue= 40 |pages= 37327-34 |year= 2001 |pmid= 11489896 |doi= 10.1074/jbc.M105313200 }}
* {{cite journal | vauthors = Bauer MF, Rothbauer U, Mühlenbein N, Smith RJ, Gerbitz K, Neupert W, Brunner M, Hofmann S | title = The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom | journal = FEBS Letters | volume = 464 | issue = 1-2 | pages = 41–7 | date = Dec 1999 | pmid = 10611480 | doi = 10.1016/S0014-5793(99)01665-8 }}
*{{cite journal | author=Roesch K, Curran SP, Tranebjaerg L, Koehler CM |title=Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex. |journal=Hum. Mol. Genet. |volume=11 |issue= 5 |pages= 477-86 |year= 2002 |pmid= 11875042 |doi= }}
* {{cite journal | vauthors = Paschen SA, Rothbauer U, Káldi K, Bauer MF, Neupert W, Brunner M | title = The role of the TIM8-13 complex in the import of Tim23 into mitochondria | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6392–400 | date = Dec 2000 | pmid = 11101512 | pmc = 305865 | doi = 10.1093/emboj/19.23.6392 }}
*{{cite journal | author=Chacinska A, Pfanner N, Meisinger C |title=How mitochondria import hydrophilic and hydrophobic proteins. |journal=Trends Cell Biol. |volume=12 |issue= 7 |pages= 299-303 |year= 2003 |pmid= 12185844 |doi= }}
* {{cite journal | vauthors = Rothbauer U, Hofmann S, Mühlenbein N, Paschen SA, Gerbitz KD, Neupert W, Brunner M, Bauer MF | title = Role of the deafness dystonia peptide 1 (DDP1) in import of human Tim23 into the inner membrane of mitochondria | journal = The Journal of Biological Chemistry | volume = 276 | issue = 40 | pages = 37327–34 | date = Oct 2001 | pmid = 11489896 | doi = 10.1074/jbc.M105313200 }}
*{{cite journal | author=Curran SP, Leuenberger D, Schmidt E, Koehler CM |title=The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins. |journal=J. Cell Biol. |volume=158 |issue= 6 |pages= 1017-27 |year= 2002 |pmid= 12221072 |doi= 10.1083/jcb.200205124 }}
* {{cite journal | vauthors = Roesch K, Curran SP, Tranebjaerg L, Koehler CM | title = Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex | journal = Human Molecular Genetics | volume = 11 | issue = 5 | pages = 477–86 | date = Mar 2002 | pmid = 11875042 | doi = 10.1093/hmg/11.5.477 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Chacinska A, Pfanner N, Meisinger C | title = How mitochondria import hydrophilic and hydrophobic proteins | journal = Trends in Cell Biology | volume = 12 | issue = 7 | pages = 299–303 | date = Jul 2002 | pmid = 12185844 | doi = 10.1016/S0962-8924(02)02310-3 }}
*{{cite journal  | author=Roesch K, Hynds PJ, Varga R, ''et al.'' |title=The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex. |journal=Hum. Mol. Genet. |volume=13 |issue= 18 |pages= 2101-11 |year= 2005 |pmid= 15254020 |doi= 10.1093/hmg/ddh217 }}
* {{cite journal | vauthors = Curran SP, Leuenberger D, Schmidt E, Koehler CM | title = The role of the Tim8p-Tim13p complex in a conserved import pathway for mitochondrial polytopic inner membrane proteins | journal = The Journal of Cell Biology | volume = 158 | issue = 6 | pages = 1017–27 | date = Sep 2002 | pmid = 12221072 | pmc = 2173223 | doi = 10.1083/jcb.200205124 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Roesch K, Hynds PJ, Varga R, Tranebjaerg L, Koehler CM | title = The calcium-binding aspartate/glutamate carriers, citrin and aralar1, are new substrates for the DDP1/TIMM8a-TIMM13 complex | journal = Human Molecular Genetics | volume = 13 | issue = 18 | pages = 2101–11 | date = Sep 2004 | pmid = 15254020 | doi = 10.1093/hmg/ddh217 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Molecular Systems Biology | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:26, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Mitochondrial import inner membrane translocase subunit Tim13 is an enzyme that in humans is encoded by the TIMM13 gene.[1][2][3]

Function

This gene encodes a translocase with similarity to yeast mitochondrial proteins that are involved in the import of metabolite transporters from the cytoplasm and into the mitochondrial inner membrane. The encoded protein and the TIMM8a protein form a 70 kDa complex in the intermembrane space. This gene is in a head-to-tail orientation with the gene for lamin B2.[3]

Interactions

TIMM13 has been shown to interact with TIMM8A.[4][5]

References

  1. ↑ Jin H, Kendall E, Freeman TC, Roberts RG, Vetrie DL (Nov 1999). "The human family of Deafness/Dystonia peptide (DDP) related mitochondrial import proteins". Genomics. 61 (3): 259–67. doi:10.1006/geno.1999.5966. PMID 10552927.
  2. ↑ Gentle IE, Perry AJ, Alcock FH, Likić VA, Dolezal P, Ng ET, Purcell AW, McConnville M, Naderer T, Chanez AL, Charrière F, Aschinger C, Schneider A, Tokatlidis K, Lithgow T (May 2007). "Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space". Molecular Biology and Evolution. 24 (5): 1149–60. doi:10.1093/molbev/msm031. PMID 17329230.
  3. ↑ 3.0 3.1 "Entrez Gene: TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)".
  4. ↑ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  5. ↑ Roesch K, Curran SP, Tranebjaerg L, Koehler CM (Mar 2002). "Human deafness dystonia syndrome is caused by a defect in assembly of the DDP1/TIMM8a-TIMM13 complex". Human Molecular Genetics. 11 (5): 477–86. doi:10.1093/hmg/11.5.477. PMID 11875042.

Further reading


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