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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein Tob1''' is a [[protein]] that in humans is encoded by the ''TOB1'' [[gene]].<ref name="pmid8632892">{{cite journal | vauthors = Matsuda S, Kawamura-Tsuzuku J, Ohsugi M, Yoshida M, Emi M, Nakamura Y, Onda M, Yoshida Y, Nishiyama A, Yamamoto T | title = Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity | journal = Oncogene | volume = 12 | issue = 4 | pages = 705–13 | date = Feb 1996 | pmid = 8632892 | pmc =  | doi =  }}</ref><ref name="pmid17785442">{{cite journal | vauthors = Ezzeddine N, Chang TC, Zhu W, Yamashita A, Chen CY, Zhong Z, Yamashita Y, Zheng D, Shyu AB | title = Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation | journal = Molecular and Cellular Biology | volume = 27 | issue = 22 | pages = 7791–801 | date = Nov 2007 | pmid = 17785442 | pmc = 2169145 | doi = 10.1128/MCB.01254-07 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TOB1 transducer of ERBB2, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10140| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_TOB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2d5r.
| PDB = {{PDB2|2d5r}}
| Name = Transducer of ERBB2, 1
| HGNCid = 11979
| Symbol = TOB1
| AltSymbols =; APRO6; MGC104792; MGC34446; PIG49; TOB; TROB; TROB1
| OMIM = 605523
| ECnumber = 
| Homologene = 31334
| MGIid = 1349721
| GeneAtlas_image1 = PBB_GE_TOB1_202704_at_tn.png
| Function = {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0046332 |text = SMAD binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007184 |text = SMAD protein nuclear translocation}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}} {{GNF_GO|id=GO:0030514 |text = negative regulation of BMP signaling pathway}} {{GNF_GO|id=GO:0045668 |text = negative regulation of osteoblast differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10140
    | Hs_Ensembl = ENSG00000141232
    | Hs_RefseqProtein = NP_005740
    | Hs_RefseqmRNA = NM_005749
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 46295340
    | Hs_GenLoc_end = 46296377
    | Hs_Uniprot = P50616
    | Mm_EntrezGene = 22057
    | Mm_Ensembl = ENSMUSG00000037573
    | Mm_RefseqmRNA = NM_009427
    | Mm_RefseqProtein = NP_033453
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 94027544
    | Mm_GenLoc_end = 94031585
    | Mm_Uniprot = Q3UQ91
  }}
}}
'''Transducer of ERBB2, 1''', also known as '''TOB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TOB1 transducer of ERBB2, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10140| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein suppresses cell growth in tissue culture. The protein undergoes phosphorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein supresses cell growth in tissue culture. The protein undergoes phophorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.<ref name="entrez">{{cite web | title = Entrez Gene: TOB1 transducer of ERBB2, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10140| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Sasaki S, Imai K |title=[Monoclonal antibody induces apoptosis against cancer cells] |journal=Nippon Rinsho |volume=60 |issue= 3 |pages= 451-6 |year= 2002 |pmid= 11904957 |doi=  }}
*{{cite journal  | author=Matsuda S, Kawamura-Tsuzuku J, Ohsugi M, ''et al.'' |title=Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity. |journal=Oncogene |volume=12 |issue= 4 |pages= 705-13 |year= 1996 |pmid= 8632892 |doi=  }}
*{{cite journal  | author=Yoshida Y, Matsuda S, Yamamoto T |title=Cloning and characterization of the mouse tob gene. |journal=Gene |volume=191 |issue= 1 |pages= 109-13 |year= 1997 |pmid= 9210596 |doi=  }}
*{{cite journal  | author=Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, ''et al.'' |title=Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases. |journal=Oncogene |volume=18 |issue= 52 |pages= 7432-41 |year= 2000 |pmid= 10602502 |doi= 10.1038/sj.onc.1203193 }}
*{{cite journal  | author=Yoshida Y, Tanaka S, Umemori H, ''et al.'' |title=Negative regulation of BMP/Smad signaling by Tob in osteoblasts. |journal=Cell |volume=103 |issue= 7 |pages= 1085-97 |year= 2001 |pmid= 11163184 |doi=  }}
*{{cite journal  | author=Suzuki T, Matsuda S, Tsuzuku JK, ''et al.'' |title=A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob. |journal=Genes Cells |volume=6 |issue= 2 |pages= 131-8 |year= 2001 |pmid= 11260258 |doi=  }}
*{{cite journal  | author=Jin Cho S, La  M, Ahn JK, ''et al.'' |title=Tob-mediated cross-talk between MARCKS phosphorylation and ErbB-2 activation. |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 2 |pages= 273-7 |year= 2001 |pmid= 11327693 |doi= 10.1006/bbrc.2001.4773 }}
*{{cite journal  | author=Yoshida Y, Hosoda E, Nakamura T, Yamamoto T |title=Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. |journal=Jpn. J. Cancer Res. |volume=92 |issue= 6 |pages= 592-6 |year= 2001 |pmid= 11429045 |doi=  }}
*{{cite journal  | author=Tzachanis D, Freeman GJ, Hirano N, ''et al.'' |title=Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. |journal=Nat. Immunol. |volume=2 |issue= 12 |pages= 1174-82 |year= 2001 |pmid= 11694881 |doi= 10.1038/ni730 }}
*{{cite journal  | author=Suzuki T, K-Tsuzuku J, Ajima R, ''et al.'' |title=Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation. |journal=Genes Dev. |volume=16 |issue= 11 |pages= 1356-70 |year= 2002 |pmid= 12050114 |doi= 10.1101/gad.962802 }}
*{{cite journal  | author=Sasajima H, Nakagawa K, Yokosawa H |title=Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system. |journal=Eur. J. Biochem. |volume=269 |issue= 14 |pages= 3596-604 |year= 2002 |pmid= 12135500 |doi=  }}
*{{cite journal  | author=Maekawa M, Nishida E, Tanoue T |title=Identification of the Anti-proliferative protein Tob as a MAPK substrate. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37783-7 |year= 2002 |pmid= 12151396 |doi= 10.1074/jbc.M204506200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Yoshida Y, von Bubnoff A, Ikematsu N, ''et al.'' |title=Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling. |journal=Mech. Dev. |volume=120 |issue= 5 |pages= 629-37 |year= 2004 |pmid= 12782279 |doi=  }}
*{{cite journal  | author=Iwanaga K, Sueoka N, Sato A, ''et al.'' |title=Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer. |journal=Cancer Lett. |volume=202 |issue= 1 |pages= 71-9 |year= 2004 |pmid= 14643028 |doi=  }}
*{{cite journal  | author=Maekawa M, Yamamoto T, Nishida E |title=Regulation of subcellular localization of the antiproliferative protein Tob by its nuclear export signal and bipartite nuclear localization signal sequences. |journal=Exp. Cell Res. |volume=295 |issue= 1 |pages= 59-65 |year= 2004 |pmid= 15051490 |doi= 10.1016/j.yexcr.2003.12.016 }}
*{{cite journal  | author=Kawamura-Tsuzuku J, Suzuki T, Yoshida Y, Yamamoto T |title=Nuclear localization of Tob is important for regulation of its antiproliferative activity. |journal=Oncogene |volume=23 |issue= 39 |pages= 6630-8 |year= 2004 |pmid= 15235587 |doi= 10.1038/sj.onc.1207890 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Okochi K, Suzuki T, Inoue J, ''et al.'' |title=Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control. |journal=Genes Cells |volume=10 |issue= 2 |pages= 151-63 |year= 2005 |pmid= 15676026 |doi= 10.1111/j.1365-2443.2005.00826.x }}
}}
{{refend}}


{{protein-stub}}
TOB1 has been shown to [[Protein-protein interaction|interact]] with:
{{WikiDoc Sources}}
* [[CNOT7]],<ref name = pmid18056425>{{cite journal | vauthors = Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, Tsujimoto M, Suzuki T, Katada T, Hoshino S | title = Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases | journal = Genes & Development | volume = 21 | issue = 23 | pages = 3135–48 | date = Dec 2007 | pmid = 18056425 | pmc = 2081979 | doi = 10.1101/gad.1597707 }}</ref><ref name = pmid10602502>{{cite journal | vauthors = Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T | title = Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases | journal = Oncogene | volume = 18 | issue = 52 | pages = 7432–41 | date = Dec 1999 | pmid = 10602502 | doi = 10.1038/sj.onc.1203193 }}</ref>
* [[MAPK1]]<ref name = pmid12151396>{{cite journal | vauthors = Maekawa M, Nishida E, Tanoue T | title = Identification of the Anti-proliferative protein Tob as a MAPK substrate | journal = The Journal of Biological Chemistry | volume = 277 | issue = 40 | pages = 37783–7 | date = Oct 2002 | pmid = 12151396 | doi = 10.1074/jbc.M204506200 }}</ref>
* [[MARCKS]],<ref name = pmid11327693>{{cite journal | vauthors = Jin Cho S, La M, Ahn JK, Meadows GG, Joe CO | title = Tob-mediated cross-talk between MARCKS phosphorylation and ErbB-2 activation | journal = Biochemical and Biophysical Research Communications | volume = 283 | issue = 2 | pages = 273–7 | date = May 2001 | pmid = 11327693 | doi = 10.1006/bbrc.2001.4773 }}</ref>
* [[Mitogen-activated protein kinase 9]],<ref name = pmid12151396/> and
* [[RPS6KA1]].<ref name = pmid11260258>{{cite journal | vauthors = Suzuki T, Matsuda S, Tsuzuku JK, Yoshida Y, Yamamoto T | title = A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob | journal = Genes to Cells | volume = 6 | issue = 2 | pages = 131–8 | date = Feb 2001 | pmid = 11260258 | doi =  10.1046/j.1365-2443.2001.00406.x}}</ref>
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Sasaki S, Imai K | title = [Monoclonal antibody induces apoptosis against cancer cells] | journal = Nihon Rinsho. Japanese Journal of Clinical Medicine | volume = 60 | issue = 3 | pages = 451–6 | date = Mar 2002 | pmid = 11904957 | doi =  }}
* {{cite journal | vauthors = Yoshida Y, Matsuda S, Yamamoto T | title = Cloning and characterization of the mouse tob gene | journal = Gene | volume = 191 | issue = 1 | pages = 109–13 | date = May 1997 | pmid = 9210596 | doi = 10.1016/S0378-1119(97)00049-8 }}
* {{cite journal | vauthors = Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T | title = Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases | journal = Oncogene | volume = 18 | issue = 52 | pages = 7432–41 | date = Dec 1999 | pmid = 10602502 | doi = 10.1038/sj.onc.1203193 }}
* {{cite journal | vauthors = Yoshida Y, Tanaka S, Umemori H, Minowa O, Usui M, Ikematsu N, Hosoda E, Imamura T, Kuno J, Yamashita T, Miyazono K, Noda M, Noda T, Yamamoto T | title = Negative regulation of BMP/Smad signaling by Tob in osteoblasts | journal = Cell | volume = 103 | issue = 7 | pages = 1085–97 | date = Dec 2000 | pmid = 11163184 | doi = 10.1016/S0092-8674(00)00211-7 }}
* {{cite journal | vauthors = Suzuki T, Matsuda S, Tsuzuku JK, Yoshida Y, Yamamoto T | title = A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob | journal = Genes to Cells | volume = 6 | issue = 2 | pages = 131–8 | date = Feb 2001 | pmid = 11260258 | doi = 10.1046/j.1365-2443.2001.00406.x }}
* {{cite journal | vauthors = Jin Cho S, La M, Ahn JK, Meadows GG, Joe CO | title = Tob-mediated cross-talk between MARCKS phosphorylation and ErbB-2 activation | journal = Biochemical and Biophysical Research Communications | volume = 283 | issue = 2 | pages = 273–7 | date = May 2001 | pmid = 11327693 | doi = 10.1006/bbrc.2001.4773 }}
* {{cite journal | vauthors = Yoshida Y, Hosoda E, Nakamura T, Yamamoto T | title = Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex | journal = Japanese Journal of Cancer Research | volume = 92 | issue = 6 | pages = 592–6 | date = Jun 2001 | pmid = 11429045 | doi = 10.1111/j.1349-7006.2001.tb01135.x }}
* {{cite journal | vauthors = Tzachanis D, Freeman GJ, Hirano N, van Puijenbroek AA, Delfs MW, Berezovskaya A, Nadler LM, Boussiotis VA | title = Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells | journal = Nature Immunology | volume = 2 | issue = 12 | pages = 1174–82 | date = Dec 2001 | pmid = 11694881 | doi = 10.1038/ni730 }}
* {{cite journal | vauthors = Suzuki T, K-Tsuzuku J, Ajima R, Nakamura T, Yoshida Y, Yamamoto T | title = Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation | journal = Genes & Development | volume = 16 | issue = 11 | pages = 1356–70 | date = Jun 2002 | pmid = 12050114 | pmc = 186319 | doi = 10.1101/gad.962802 }}
* {{cite journal | vauthors = Sasajima H, Nakagawa K, Yokosawa H | title = Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system | journal = European Journal of Biochemistry / FEBS | volume = 269 | issue = 14 | pages = 3596–604 | date = Jul 2002 | pmid = 12135500 | doi = 10.1046/j.1432-1033.2002.03052.x }}
* {{cite journal | vauthors = Maekawa M, Nishida E, Tanoue T | title = Identification of the Anti-proliferative protein Tob as a MAPK substrate | journal = The Journal of Biological Chemistry | volume = 277 | issue = 40 | pages = 37783–7 | date = Oct 2002 | pmid = 12151396 | doi = 10.1074/jbc.M204506200 }}
* {{cite journal | vauthors = Yoshida Y, von Bubnoff A, Ikematsu N, Blitz IL, Tsuzuku JK, Yoshida EH, Umemori H, Miyazono K, Yamamoto T, Cho KW | title = Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling | journal = Mechanisms of Development | volume = 120 | issue = 5 | pages = 629–37 | date = May 2003 | pmid = 12782279 | doi = 10.1016/S0925-4773(03)00020-0 }}
* {{cite journal | vauthors = Iwanaga K, Sueoka N, Sato A, Sakuragi T, Sakao Y, Tominaga M, Suzuki T, Yoshida Y, K-Tsuzuku J, Yamamoto T, Hayashi S, Nagasawa K, Sueoka E | title = Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer | journal = Cancer Letters | volume = 202 | issue = 1 | pages = 71–9 | date = Dec 2003 | pmid = 14643028 | doi = 10.1016/j.canlet.2003.08.019 }}
* {{cite journal | vauthors = Maekawa M, Yamamoto T, Nishida E | title = Regulation of subcellular localization of the antiproliferative protein Tob by its nuclear export signal and bipartite nuclear localization signal sequences | journal = Experimental Cell Research | volume = 295 | issue = 1 | pages = 59–65 | date = Apr 2004 | pmid = 15051490 | doi = 10.1016/j.yexcr.2003.12.016 }}
* {{cite journal | vauthors = Kawamura-Tsuzuku J, Suzuki T, Yoshida Y, Yamamoto T | title = Nuclear localization of Tob is important for regulation of its antiproliferative activity | journal = Oncogene | volume = 23 | issue = 39 | pages = 6630–8 | date = Aug 2004 | pmid = 15235587 | doi = 10.1038/sj.onc.1207890 }}
* {{cite journal | vauthors = Okochi K, Suzuki T, Inoue J, Matsuda S, Yamamoto T | title = Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control | journal = Genes to Cells | volume = 10 | issue = 2 | pages = 151–63 | date = Feb 2005 | pmid = 15676026 | doi = 10.1111/j.1365-2443.2005.00826.x }}
{{Refend}}
 
== External links ==
* {{UCSC genome browser|TOB1}}
* {{UCSC gene details|TOB1}}
 
{{PDB Gallery|geneid=10140}}
 
{{Gene-17-stub}}

Latest revision as of 02:03, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein Tob1 is a protein that in humans is encoded by the TOB1 gene.[1][2][3]

Function

This gene encodes a member of the tob/btg1 family of anti-proliferative proteins that have the potential to regulate cell growth. When exogenously expressed, this protein suppresses cell growth in tissue culture. The protein undergoes phosphorylation by a serine/threonine kinase, 90 kDa ribosomal S6 kinase. Interactions of this protein with the v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 gene product p185 interferes with growth suppression. This protein inhibits T cell proliferation and transcription of cytokines and cyclins. The protein interacts with both mothers against decapentaplegic Drosophila homolog 2 and 4 to enhance their DNA binding activity. This interaction inhibits interleukin 2 transcription in T cells.[3]

Interactions

TOB1 has been shown to interact with:

References

  1. ↑ Matsuda S, Kawamura-Tsuzuku J, Ohsugi M, Yoshida M, Emi M, Nakamura Y, Onda M, Yoshida Y, Nishiyama A, Yamamoto T (Feb 1996). "Tob, a novel protein that interacts with p185erbB2, is associated with anti-proliferative activity". Oncogene. 12 (4): 705–13. PMID 8632892.
  2. ↑ Ezzeddine N, Chang TC, Zhu W, Yamashita A, Chen CY, Zhong Z, Yamashita Y, Zheng D, Shyu AB (Nov 2007). "Human TOB, an antiproliferative transcription factor, is a poly(A)-binding protein-dependent positive regulator of cytoplasmic mRNA deadenylation". Molecular and Cellular Biology. 27 (22): 7791–801. doi:10.1128/MCB.01254-07. PMC 2169145. PMID 17785442.
  3. ↑ 3.0 3.1 "Entrez Gene: TOB1 transducer of ERBB2, 1".
  4. ↑ Funakoshi Y, Doi Y, Hosoda N, Uchida N, Osawa M, Shimada I, Tsujimoto M, Suzuki T, Katada T, Hoshino S (Dec 2007). "Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases". Genes & Development. 21 (23): 3135–48. doi:10.1101/gad.1597707. PMC 2081979. PMID 18056425.
  5. ↑ Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (Dec 1999). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502.
  6. ↑ 6.0 6.1 Maekawa M, Nishida E, Tanoue T (Oct 2002). "Identification of the Anti-proliferative protein Tob as a MAPK substrate". The Journal of Biological Chemistry. 277 (40): 37783–7. doi:10.1074/jbc.M204506200. PMID 12151396.
  7. ↑ Jin Cho S, La M, Ahn JK, Meadows GG, Joe CO (May 2001). "Tob-mediated cross-talk between MARCKS phosphorylation and ErbB-2 activation". Biochemical and Biophysical Research Communications. 283 (2): 273–7. doi:10.1006/bbrc.2001.4773. PMID 11327693.
  8. ↑ Suzuki T, Matsuda S, Tsuzuku JK, Yoshida Y, Yamamoto T (Feb 2001). "A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob". Genes to Cells. 6 (2): 131–8. doi:10.1046/j.1365-2443.2001.00406.x. PMID 11260258.

Further reading

  • Sasaki S, Imai K (Mar 2002). "[Monoclonal antibody induces apoptosis against cancer cells]". Nihon Rinsho. Japanese Journal of Clinical Medicine. 60 (3): 451–6. PMID 11904957.
  • Yoshida Y, Matsuda S, Yamamoto T (May 1997). "Cloning and characterization of the mouse tob gene". Gene. 191 (1): 109–13. doi:10.1016/S0378-1119(97)00049-8. PMID 9210596.
  • Ikematsu N, Yoshida Y, Kawamura-Tsuzuku J, Ohsugi M, Onda M, Hirai M, Fujimoto J, Yamamoto T (Dec 1999). "Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a component of the CCR4 transcriptional regulatory complex capable of binding cyclin-dependent kinases". Oncogene. 18 (52): 7432–41. doi:10.1038/sj.onc.1203193. PMID 10602502.
  • Yoshida Y, Tanaka S, Umemori H, Minowa O, Usui M, Ikematsu N, Hosoda E, Imamura T, Kuno J, Yamashita T, Miyazono K, Noda M, Noda T, Yamamoto T (Dec 2000). "Negative regulation of BMP/Smad signaling by Tob in osteoblasts". Cell. 103 (7): 1085–97. doi:10.1016/S0092-8674(00)00211-7. PMID 11163184.
  • Suzuki T, Matsuda S, Tsuzuku JK, Yoshida Y, Yamamoto T (Feb 2001). "A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob". Genes to Cells. 6 (2): 131–8. doi:10.1046/j.1365-2443.2001.00406.x. PMID 11260258.
  • Jin Cho S, La M, Ahn JK, Meadows GG, Joe CO (May 2001). "Tob-mediated cross-talk between MARCKS phosphorylation and ErbB-2 activation". Biochemical and Biophysical Research Communications. 283 (2): 273–7. doi:10.1006/bbrc.2001.4773. PMID 11327693.
  • Yoshida Y, Hosoda E, Nakamura T, Yamamoto T (Jun 2001). "Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex". Japanese Journal of Cancer Research. 92 (6): 592–6. doi:10.1111/j.1349-7006.2001.tb01135.x. PMID 11429045.
  • Tzachanis D, Freeman GJ, Hirano N, van Puijenbroek AA, Delfs MW, Berezovskaya A, Nadler LM, Boussiotis VA (Dec 2001). "Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells". Nature Immunology. 2 (12): 1174–82. doi:10.1038/ni730. PMID 11694881.
  • Suzuki T, K-Tsuzuku J, Ajima R, Nakamura T, Yoshida Y, Yamamoto T (Jun 2002). "Phosphorylation of three regulatory serines of Tob by Erk1 and Erk2 is required for Ras-mediated cell proliferation and transformation". Genes & Development. 16 (11): 1356–70. doi:10.1101/gad.962802. PMC 186319. PMID 12050114.
  • Sasajima H, Nakagawa K, Yokosawa H (Jul 2002). "Antiproliferative proteins of the BTG/Tob family are degraded by the ubiquitin-proteasome system". European Journal of Biochemistry / FEBS. 269 (14): 3596–604. doi:10.1046/j.1432-1033.2002.03052.x. PMID 12135500.
  • Maekawa M, Nishida E, Tanoue T (Oct 2002). "Identification of the Anti-proliferative protein Tob as a MAPK substrate". The Journal of Biological Chemistry. 277 (40): 37783–7. doi:10.1074/jbc.M204506200. PMID 12151396.
  • Yoshida Y, von Bubnoff A, Ikematsu N, Blitz IL, Tsuzuku JK, Yoshida EH, Umemori H, Miyazono K, Yamamoto T, Cho KW (May 2003). "Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling". Mechanisms of Development. 120 (5): 629–37. doi:10.1016/S0925-4773(03)00020-0. PMID 12782279.
  • Iwanaga K, Sueoka N, Sato A, Sakuragi T, Sakao Y, Tominaga M, Suzuki T, Yoshida Y, K-Tsuzuku J, Yamamoto T, Hayashi S, Nagasawa K, Sueoka E (Dec 2003). "Alteration of expression or phosphorylation status of tob, a novel tumor suppressor gene product, is an early event in lung cancer". Cancer Letters. 202 (1): 71–9. doi:10.1016/j.canlet.2003.08.019. PMID 14643028.
  • Maekawa M, Yamamoto T, Nishida E (Apr 2004). "Regulation of subcellular localization of the antiproliferative protein Tob by its nuclear export signal and bipartite nuclear localization signal sequences". Experimental Cell Research. 295 (1): 59–65. doi:10.1016/j.yexcr.2003.12.016. PMID 15051490.
  • Kawamura-Tsuzuku J, Suzuki T, Yoshida Y, Yamamoto T (Aug 2004). "Nuclear localization of Tob is important for regulation of its antiproliferative activity". Oncogene. 23 (39): 6630–8. doi:10.1038/sj.onc.1207890. PMID 15235587.
  • Okochi K, Suzuki T, Inoue J, Matsuda S, Yamamoto T (Feb 2005). "Interaction of anti-proliferative protein Tob with poly(A)-binding protein and inducible poly(A)-binding protein: implication of Tob in translational control". Genes to Cells. 10 (2): 151–63. doi:10.1111/j.1365-2443.2005.00826.x. PMID 15676026.

External links

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