NUDT21: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Cleavage and polyadenylation specificity factor subunit 5''' ('''CPSF5''') is a [[enzyme]] that in humans is encoded by the ''NUDT21'' [[gene]].<ref name="pmid9659921">{{cite journal |vauthors=Ruegsegger U, Blank D, Keller W | title = Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits | journal = Mol Cell | volume = 1 | issue = 2 | pages = 243–53 |date=Jul 1998 | pmid = 9659921 | pmc =  | doi =10.1016/S1097-2765(00)80025-8  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11051| accessdate = }}</ref> It belongs to the [[Nudix family]] of hydrolases.
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is one subunit of the [[cleavage factor]] Im complex required for 3' RNA cleavage and polyadenylation processing.<ref name="Hardy">{{cite journal|last1=Hardy|first1=J. G.|last2=Norbury|first2=C. J.|title=Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation|journal=Biochemical Society Transactions|date=15 August 2016|volume=44|issue=4|pages=1051–1057|doi=10.1042/BST20160078}}</ref> The interaction of the protein with the [[RNA]] is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides.<ref name="entrez" />
{{GNF_Protein_box
| image = PBB_Protein_NUDT21_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cl3.
| PDB = {{PDB2|2cl3}}, {{PDB2|2j8q}}
| Name = Nudix (nucleoside diphosphate linked moiety X)-type motif 21
| HGNCid = 13870
| Symbol = NUDT21
| AltSymbols =; CFIM25; CPSF5; DKFZp686H1588
| OMIM = 604978
| ECnumber = 
| Homologene = 5090
| MGIid = 
| GeneAtlas_image1 = PBB_GE_NUDT21_202697_at_tn.png
| GeneAtlas_image2 = PBB_GE_NUDT21_213461_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}  
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005813 |text = centrosome}} {{GNF_GO|id=GO:0042382 |text = paraspeckles}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11051
    | Hs_Ensembl = ENSG00000167005
    | Hs_RefseqProtein = NP_008937
    | Hs_RefseqmRNA = NM_007006
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 55020550
    | Hs_GenLoc_end = 55042766
    | Hs_Uniprot = O43809
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Nudix (nucleoside diphosphate linked moiety X)-type motif 21''', also known as '''NUDT21''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11051| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==References==
{{PBB_Summary
{{reflist}}
| section_title =  
| summary_text = The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides.<ref name="entrez">{{cite web | title = Entrez Gene: NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11051| accessdate = }}</ref>
}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Rüegsegger U, Beyer K, Keller W |title=Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors. |journal=J. Biol. Chem. |volume=271 |issue= 11 |pages= 6107-13 |year= 1996 |pmid= 8626397 |doi=  }}
*{{cite journal  |vauthors=Rüegsegger U, Beyer K, Keller W |title=Purification and characterization of human cleavage factor Im involved in the 3' end processing of messenger RNA precursors |journal=J. Biol. Chem. |volume=271 |issue= 11 |pages= 6107–13 |year= 1996 |pmid= 8626397 |doi=10.1074/jbc.271.11.6107 }}
*{{cite journal  | author=Rüegsegger U, Blank D, Keller W |title=Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits. |journal=Mol. Cell |volume=1 |issue= 2 |pages= 243-53 |year= 1998 |pmid= 9659921 |doi= }}
*{{cite journal  | author=de Vries H |title=Human pre-mRNA cleavage factor IIm contains homologs of yeast proteins and bridges two other cleavage factors |journal=EMBO J. |volume=19 |issue= 21 |pages= 5895–904 |year= 2000 |pmid= 11060040 |doi= 10.1093/emboj/19.21.5895  | pmc=305781 |name-list-format=vanc| author2=Rüegsegger U | author3=Hübner W | display-authors=3  | last4=Friedlein  | first4=A  | last5=Langen  | first5=H  | last6=Keller  | first6=W }}
*{{cite journal | author=de Vries H, Rüegsegger U, Hübner W, ''et al.'' |title=Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. |journal=EMBO J. |volume=19 |issue= 21 |pages= 5895-904 |year= 2000 |pmid= 11060040 |doi= 10.1093/emboj/19.21.5895 }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  | author=Wiemann S |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072  |name-list-format=vanc| author2=Weil B | author3=Wellenreuther R | display-authors=3  | last4=Gassenhuber  | first4=J  | last5=Glassl  | first5=S  | last6=Ansorge  | first6=W  | last7=Böcher  | first7=M  | last8=Blöcker  | first8=H  | last9=Bauersachs  | first9=S }}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  | author=Simpson JC |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058  | pmc=1083732 |name-list-format=vanc| author2=Wellenreuther R  | author3=Poustka A  | display-authors=3  | last4=Pepperkok  | first4=R  | last5=Wiemann  | first5=S }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
*{{cite journal  |vauthors=Kim H, Lee Y |title=Interaction of poly(A) polymerase with the 25-kDa subunit of cleavage factor I |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 2 |pages= 513–8 |year= 2002 |pmid= 11716503 |doi= 10.1006/bbrc.2001.5992 }}
*{{cite journal  | author=Kim H, Lee Y |title=Interaction of poly(A) polymerase with the 25-kDa subunit of cleavage factor I. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 2 |pages= 513-8 |year= 2002 |pmid= 11716503 |doi= 10.1006/bbrc.2001.5992 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Awasthi S, Alwine JC |title=Association of polyadenylation cleavage factor I with U1 snRNP |journal=RNA |volume=9 |issue= 11 |pages= 1400–9 |year= 2003 |pmid= 14561889 |doi=10.1261/rna.5104603  | pmc=1287061  }}
*{{cite journal  | author=Awasthi S, Alwine JC |title=Association of polyadenylation cleavage factor I with U1 snRNP. |journal=RNA |volume=9 |issue= 11 |pages= 1400-9 |year= 2003 |pmid= 14561889 |doi= }}
*{{cite journal  |vauthors=Brown KM, Gilmartin GM |title=A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im |journal=Mol. Cell |volume=12 |issue= 6 |pages= 1467–76 |year= 2004 |pmid= 14690600 |doi=10.1016/S1097-2765(03)00453-2  }}
*{{cite journal  | author=Brown KM, Gilmartin GM |title=A mechanism for the regulation of pre-mRNA 3' processing by human cleavage factor Im. |journal=Mol. Cell |volume=12 |issue= 6 |pages= 1467-76 |year= 2004 |pmid= 14690600 |doi=  }}
*{{cite journal  | author=Bouwmeester T |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 |name-list-format=vanc| author2=Bauch A  | author3=Ruffner H  | display-authors=3  | last4=Angrand  | first4=Pierre-Olivier  | last5=Bergamini  | first5=Giovanna  | last6=Croughton  | first6=Karen  | last7=Cruciat  | first7=Cristina  | last8=Eberhard  | first8=Dirk  | last9=Gagneur  | first9=Julien }}
*{{cite journal | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal  | author=Dettwiler S |title=Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization |journal=J. Biol. Chem. |volume=279 |issue= 34 |pages= 35788–97 |year= 2005 |pmid= 15169763 |doi= 10.1074/jbc.M403927200 |name-list-format=vanc| author2=Aringhieri C  | author3=Cardinale S  | display-authors=3  | last4=Keller  | first4=W  | last5=Barabino  | first5=SM }}
*{{cite journal | author=Dettwiler S, Aringhieri C, Cardinale S, ''et al.'' |title=Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 34 |pages= 35788-97 |year= 2005 |pmid= 15169763 |doi= 10.1074/jbc.M403927200 }}
*{{cite journal  |vauthors=Lehner B, Sanderson CM |title=A Protein Interaction Framework for Human mRNA Degradation |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004  | pmc=442147 }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Wiemann S |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704  | pmc=528930  |name-list-format=vanc| author2=Arlt D  | author3=Huber W  | display-authors=3  | last4=Wellenreuther  | first4=R  | last5=Schleeger  | first5=S  | last6=Mehrle  | first6=A  | last7=Bechtel  | first7=S  | last8=Sauermann  | first8=M  | last9=Korf  | first9=U }}
*{{cite journal | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  | author=Rush J |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046  |name-list-format=vanc| author2=Moritz A  | author3=Lee KA  | display-authors=3  | last4=Guo  | first4=Ailan  | last5=Goss  | first5=Valerie L  | last6=Spek  | first6=Erik J  | last7=Zhang  | first7=Hui  | last8=Zha  | first8=Xiang-Ming  | last9=Polakiewicz  | first9=Roberto D }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  | author=Andersen JS |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207  |name-list-format=vanc| author2=Lam YW  | author3=Leung AK  | display-authors=3  | last4=Ong  | first4=Shao-En  | last5=Lyon  | first5=Carol E.  | last6=Lamond  | first6=Angus I.  | last7=Mann  | first7=Matthias }}
*{{cite journal | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal  | author=Stelzl U |title=A human protein-protein interaction network: a resource for annotating the proteome |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029  |name-list-format=vanc| author2=Worm U  | author3=Lalowski M  | display-authors=3  | last4=Haenig  | first4=Christian  | last5=Brembeck  | first5=Felix H.  | last6=Goehler  | first6=Heike  | last7=Stroedicke  | first7=Martin  | last8=Zenkner  | first8=Martina  | last9=Schoenherr  | first9=Anke }}
*{{cite journal  | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Mehrle A |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501  |name-list-format=vanc| author2=Rosenfelder H  | author3=Schupp I  | display-authors=3  | last4=Del Val  | first4=C  | last5=Arlt  | first5=D  | last6=Hahne  | first6=F  | last7=Bechtel  | first7=S  | last8=Simpson  | first8=J  | last9=Hofmann  | first9=O }}
*{{cite journal | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=11051}}
{{gene-16-stub}}


{{protein-stub}}
[[Category:Nudix hydrolases]]
{{WikiDoc Sources}}

Latest revision as of 13:20, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cleavage and polyadenylation specificity factor subunit 5 (CPSF5) is a enzyme that in humans is encoded by the NUDT21 gene.[1][2] It belongs to the Nudix family of hydrolases.

The protein encoded by this gene is one subunit of the cleavage factor Im complex required for 3' RNA cleavage and polyadenylation processing.[3] The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides.[2]

References

  1. ↑ Ruegsegger U, Blank D, Keller W (Jul 1998). "Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits". Mol Cell. 1 (2): 243–53. doi:10.1016/S1097-2765(00)80025-8. PMID 9659921.
  2. ↑ 2.0 2.1 "Entrez Gene: NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21".
  3. ↑ Hardy, J. G.; Norbury, C. J. (15 August 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–1057. doi:10.1042/BST20160078.

Further reading

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