ST8SIA1: Difference between revisions

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{{Infobox_gene}}
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'''Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase''' is an [[enzyme]] that in humans is encoded by the '''ST8SIA1''' [[gene]].<ref name="pmid7901202">{{cite journal | vauthors = Sasaki K, Watanabe E, Kawashima K, Sekine S, Dohi T, Oshima M, Hanai N, Nishi T, Hasegawa M | title = Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection | journal = J Biol Chem | volume = 268 | issue = 30 | pages = 22782–7 |date=Dec 1993 | pmid = 7901202 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6489| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
| HGNCid = 10869
| Symbol = ST8SIA1
| AltSymbols =; GD3S; SIAT8; SIAT8A; ST8Sia I; ST8SiaI
| OMIM = 601123
| ECnumber = 
| Homologene = 2282
| MGIid = 106011
| GeneAtlas_image1 = PBB_GE_ST8SIA1_210073_at_tn.png
| Function = {{GNF_GO|id=GO:0003828 |text = alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0030173 |text = integral to Golgi membrane}}
  | Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006486 |text = protein amino acid glycosylation}} {{GNF_GO|id=GO:0006688 |text = glycosphingolipid biosynthetic process}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6489
    | Hs_Ensembl = ENSG00000111728
    | Hs_RefseqProtein = NP_003025
    | Hs_RefseqmRNA = NM_003034
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 22245204
    | Hs_GenLoc_end = 22378915
    | Hs_Uniprot = Q92185
    | Mm_EntrezGene = 20449
    | Mm_Ensembl = ENSMUSG00000030283
    | Mm_RefseqmRNA = NM_011374
    | Mm_RefseqProtein = NP_035504
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 142778763
    | Mm_GenLoc_end = 142921674
    | Mm_Uniprot = A1E2I1
  }}
}}
'''ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1''', also known as '''ST8SIA1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6489| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.<ref name="entrez">{{cite web | title = Entrez Gene: ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6489| accessdate = }}</ref>
| summary_text = [[Ganglioside]]s are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by ST8SIA1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to [[GM3]] to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.<ref name="entrez"/>
 
In melanocytic cells, ST8SIA1 gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal  |vauthors=Hoek KS, Schlegel NC, Eichhoff OM, etal | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Sasaki K, Watanabe E, Kawashima K, ''et al.'' |title=Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection. |journal=J. Biol. Chem. |volume=268 |issue= 30 |pages= 22782-7 |year= 1993 |pmid= 7901202 |doi=  }}
*{{cite journal   |vauthors=Haraguchi M, Yamashiro S, Yamamoto A, etal |title=Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 22 |pages= 10455–9 |year= 1994 |pmid= 7937974 |doi=10.1073/pnas.91.22.10455 | pmc=45039  }}
*{{cite journal | author=Haraguchi M, Yamashiro S, Yamamoto A, ''et al.'' |title=Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 22 |pages= 10455-9 |year= 1994 |pmid= 7937974 |doi= }}
*{{cite journal   |vauthors=Nara K, Watanabe Y, Maruyama K, etal |title=Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 17 |pages= 7952–6 |year= 1994 |pmid= 8058740 |doi=10.1073/pnas.91.17.7952  | pmc=44522  }}
*{{cite journal | author=Nara K, Watanabe Y, Maruyama K, ''et al.'' |title=Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 17 |pages= 7952-6 |year= 1994 |pmid= 8058740 |doi=  }}
*{{cite journal   |vauthors=Sasaki K, Kurata K, Kojima N, etal |title=Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase). |journal=J. Biol. Chem. |volume=269 |issue= 22 |pages= 15950–6 |year= 1994 |pmid= 8195250 |doi=  }}
*{{cite journal | author=Sasaki K, Kurata K, Kojima N, ''et al.'' |title=Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase). |journal=J. Biol. Chem. |volume=269 |issue= 22 |pages= 15950-6 |year= 1994 |pmid= 8195250 |doi=  }}
*{{cite journal   |vauthors=Nakayama J, Fukuda MN, Hirabayashi Y, etal |title=Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme. |journal=J. Biol. Chem. |volume=271 |issue= 7 |pages= 3684–91 |year= 1996 |pmid= 8631981 |doi=  10.1074/jbc.271.7.3684}}
*{{cite journal | author=Nakayama J, Fukuda MN, Hirabayashi Y, ''et al.'' |title=Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme. |journal=J. Biol. Chem. |volume=271 |issue= 7 |pages= 3684-91 |year= 1996 |pmid= 8631981 |doi= }}
*{{cite journal   |vauthors=Matsuda Y, Nara K, Watanabe Y, etal |title=Chromosome mapping of the GD3 synthase gene (SIAT8) in human and mouse. |journal=Genomics |volume=32 |issue= 1 |pages= 137–9 |year= 1996 |pmid= 8786103 |doi= 10.1006/geno.1996.0090 }}
*{{cite journal | author=Matsuda Y, Nara K, Watanabe Y, ''et al.'' |title=Chromosome mapping of the GD3 synthase gene (SIAT8) in human and mouse. |journal=Genomics |volume=32 |issue= 1 |pages= 137-9 |year= 1996 |pmid= 8786103 |doi= 10.1006/geno.1996.0090 }}
*{{cite journal   |vauthors=De Maria R, Lenti L, Malisan F, etal |title=Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis. |journal=Science |volume=277 |issue= 5332 |pages= 1652–5 |year= 1997 |pmid= 9287216 |doi=10.1126/science.277.5332.1652  }}
*{{cite journal | author=De Maria R, Lenti L, Malisan F, ''et al.'' |title=Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis. |journal=Science |volume=277 |issue= 5332 |pages= 1652-5 |year= 1997 |pmid= 9287216 |doi= }}
*{{cite journal   |vauthors=Angata K, Suzuki M, McAuliffe J, etal |title=Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18594–601 |year= 2000 |pmid= 10766765 |doi= 10.1074/jbc.M910204199 }}
*{{cite journal | author=Angata K, Suzuki M, McAuliffe J, ''et al.'' |title=Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18594-601 |year= 2000 |pmid= 10766765 |doi= 10.1074/jbc.M910204199 }}
*{{cite journal   |vauthors=Zeng G, Gao L, Suetake K, etal |title=Variations in gene expression patterns correlated with phenotype of F-11 tumor cells whose expression of GD3-synthase is suppressed. |journal=Cancer Lett. |volume=178 |issue= 1 |pages= 91–8 |year= 2002 |pmid= 11849746 |doi=10.1016/S0304-3835(01)00817-5  }}
*{{cite journal | author=Zeng G, Gao L, Suetake K, ''et al.'' |title=Variations in gene expression patterns correlated with phenotype of F-11 tumor cells whose expression of GD3-synthase is suppressed. |journal=Cancer Lett. |volume=178 |issue= 1 |pages= 91-8 |year= 2002 |pmid= 11849746 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Furukawa K, Horie M, Okutomi K, etal |title=Isolation and functional analysis of the melanoma specific promoter region of human GD3 synthase gene. |journal=Biochim. Biophys. Acta |volume=1627 |issue= 2-3 |pages= 71–8 |year= 2003 |pmid= 12818424 |doi= 10.1016/s0167-4781(03)00076-9}}
*{{cite journal  | author=Furukawa K, Horie M, Okutomi K, ''et al.'' |title=Isolation and functional analysis of the melanoma specific promoter region of human GD3 synthase gene. |journal=Biochim. Biophys. Acta |volume=1627 |issue= 2-3 |pages= 71-8 |year= 2003 |pmid= 12818424 |doi= }}
*{{cite journal  | vauthors=Moon SK, Kim HM, Lee YC, Kim CH |title=Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33063–70 |year= 2004 |pmid= 15175338 |doi= 10.1074/jbc.M313462200 }}
*{{cite journal  | author=Moon SK, Kim HM, Lee YC, Kim CH |title=Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33063-70 |year= 2004 |pmid= 15175338 |doi= 10.1074/jbc.M313462200 }}
*{{cite journal  | vauthors=Ha KT, Lee YC, Kim CH |title=Overexpression of GD3 synthase induces apoptosis of vascular endothelial ECV304 cells through downregulation of Bcl-2. |journal=FEBS Lett. |volume=568 |issue= 1-3 |pages= 183–7 |year= 2004 |pmid= 15196944 |doi= 10.1016/j.febslet.2004.05.020 }}
*{{cite journal | author=Ha KT, Lee YC, Kim CH |title=Overexpression of GD3 synthase induces apoptosis of vascular endothelial ECV304 cells through downregulation of Bcl-2. |journal=FEBS Lett. |volume=568 |issue= 1-3 |pages= 183-7 |year= 2004 |pmid= 15196944 |doi= 10.1016/j.febslet.2004.05.020 }}
*{{cite journal   |vauthors=Tomassini B, Malisan F, Franchi L, etal |title=Calnexin suppresses GD3 synthase-induced apoptosis. |journal=FASEB J. |volume=18 |issue= 13 |pages= 1553–5 |year= 2005 |pmid= 15319364 |doi= 10.1096/fj.04-1675fje }}
*{{cite journal | author=Tomassini B, Malisan F, Franchi L, ''et al.'' |title=Calnexin suppresses GD3 synthase-induced apoptosis. |journal=FASEB J. |volume=18 |issue= 13 |pages= 1553-5 |year= 2005 |pmid= 15319364 |doi= 10.1096/fj.04-1675fje }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Teintenier-Lelièvre M, Julien S, Juliant S, etal |title=Molecular cloning and expression of a human hST8Sia VI (alpha2,8-sialyltransferase) responsible for the synthesis of the diSia motif on O-glycosylproteins. |journal=Biochem. J. |volume=392 |issue= Pt 3 |pages= 665–74 |year= 2006 |pmid= 16120058 |doi= 10.1042/BJ20051120  | pmc=1316308 }}
*{{cite journal | author=Teintenier-Lelièvre M, Julien S, Juliant S, ''et al.'' |title=Molecular cloning and expression of a human hST8Sia VI (alpha2,8-sialyltransferase) responsible for the synthesis of the diSia motif on O-glycosylproteins. |journal=Biochem. J. |volume=392 |issue= Pt 3 |pages= 665-74 |year= 2006 |pmid= 16120058 |doi= 10.1042/BJ20051120 }}
*{{cite journal   |vauthors=Kang NY, Kang Y, Kang SK, etal |title=Transcriptional regulation of the human GD3 synthase gene expression in Fas-induced Jurkat T cells: a critical role of transcription factor NF-kappaB in regulated expression. |journal=Glycobiology |volume=16 |issue= 5 |pages= 375–89 |year= 2006 |pmid= 16481330 |doi= 10.1093/glycob/cwj087 }}
*{{cite journal | author=Kang NY, Kang Y, Kang SK, ''et al.'' |title=Transcriptional regulation of the human GD3 synthase gene expression in Fas-induced Jurkat T cells: a critical role of transcription factor NF-kappaB in regulated expression. |journal=Glycobiology |volume=16 |issue= 5 |pages= 375-89 |year= 2006 |pmid= 16481330 |doi= 10.1093/glycob/cwj087 }}
*{{cite journal   |vauthors=Ko K, Furukawa K, Takahashi T, etal |title=Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers. |journal=Oncogene |volume=25 |issue= 52 |pages= 6924–35 |year= 2006 |pmid= 16862187 |doi= 10.1038/sj.onc.1209683 }}
*{{cite journal | author=Ko K, Furukawa K, Takahashi T, ''et al.'' |title=Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers. |journal=Oncogene |volume=25 |issue= 52 |pages= 6924-35 |year= 2006 |pmid= 16862187 |doi= 10.1038/sj.onc.1209683 }}
*{{cite journal   |vauthors=Szabo R, Skropeta D, etal |title=Advancement of Sialyltransferase Inhibitors: Therapeutic Challenges and Opportunities. |journal=Med. Res. Rev. |volume=37 |pages= 210-270 |year= 2017 |doi= 10.1002/med.21407 }}
}}
}}
{{refend}}
{{refend}}


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Latest revision as of 07:08, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA1 gene.[1][2]

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by ST8SIA1 is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.[2]

In melanocytic cells, ST8SIA1 gene expression may be regulated by MITF.[3]

References

  1. ↑ Sasaki K, Watanabe E, Kawashima K, Sekine S, Dohi T, Oshima M, Hanai N, Nishi T, Hasegawa M (Dec 1993). "Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection". J Biol Chem. 268 (30): 22782–7. PMID 7901202.
  2. ↑ 2.0 2.1 "Entrez Gene: ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1".
  3. ↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading



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