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{{Infobox_gene}}
'''Gamma-tubulin complex component 2''' is a [[protein]] that in humans is encoded by the ''TUBGCP2'' [[gene]].<ref name="pmid9566967">{{cite journal |vauthors=Murphy SM, Urbani L, Stearns T | title = The Mammalian γ-Tubulin Complex Contains Homologues of the Yeast Spindle Pole Body Components Spc97p and Spc98p | journal = J Cell Biol | volume = 141 | issue = 3 | pages = 663–74 |date=Jun 1998 | pmid = 9566967 | pmc = 2132743 | doi =10.1083/jcb.141.3.663  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TUBGCP2 tubulin, gamma complex associated protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10844| accessdate = }}</ref>
It is part of the gamma tubulin complex, which required for [[microtubule nucleation]] at the [[centrosome]].
==See also==
*[[Tubulin]]
* [[TUBGCP3]]
* [[TUBGCP4]]
* [[TUBGCP5]]
* [[TUBGCP6]]
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Rush J |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046  |name-list-format=vanc| author2=Moritz A  | author3=Lee KA  | display-authors=3  | last4=Guo  | first4=Ailan  | last5=Goss  | first5=Valerie L  | last6=Spek  | first6=Erik J  | last7=Zhang  | first7=Hui  | last8=Zha  | first8=Xiang-Ming  | last9=Polakiewicz  | first9=Roberto D }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  |vauthors=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8  | pmc=395752 }}
*{{cite journal  | author=Bouwmeester T |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086  |name-list-format=vanc| author2=Bauch A  | author3=Ruffner H  | display-authors=3  | last4=Angrand  | first4=Pierre-Olivier  | last5=Bergamini  | first5=Giovanna  | last6=Croughton  | first6=Karen  | last7=Cruciat  | first7=Cristina  | last8=Eberhard  | first8=Dirk  | last9=Gagneur  | first9=Julien }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Takahashi M |title=Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex |journal=Mol. Biol. Cell |volume=13 |issue= 9 |pages= 3235–45 |year= 2003 |pmid= 12221128 |doi= 10.1091/mbc.E02-02-0112  | pmc=124155  |name-list-format=vanc| author2=Yamagiwa A  | author3=Nishimura T  | display-authors=3  | last4=Mukai  | first4=H  | last5=Ono  | first5=Y }}
*{{cite journal  | author=Murphy SM |title=GCP5 and GCP6: Two New Members of the Human γ-Tubulin Complex |journal=Mol. Biol. Cell |volume=12 |issue= 11 |pages= 3340–52 |year= 2002 |pmid= 11694571 |doi=  10.1091/mbc.12.11.3340| pmc=60259  |name-list-format=vanc| author2=Preble AM  | author3=Patel UK  | display-authors=3  | last4=O'Connell  | first4=KL  | last5=Dias  | first5=DP  | last6=Moritz  | first6=M  | last7=Agard  | first7=D  | last8=Stults  | first8=JT  | last9=Stearns  | first9=T  }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=Akira  | last5=Sugano  | first5=Sumio  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
*{{cite journal  | author=Adams MD |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3–174 |year= 1995 |pmid= 7566098 |doi=<!-- none available --> |url=http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf | format=PDF  |name-list-format=vanc| author2=Kerlavage AR  | author3=Fleischmann RD  | display-authors=3  | last4=Fuldner  | first4=RA  | last5=Bult  | first5=CJ  | last6=Lee  | first6=NH  | last7=Kirkness  | first7=EF  | last8=Weinstock  | first8=KG  | last9=Gocayne  | first9=JD  }}
}}
{{refend}}
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Tubulin, gamma complex associated protein 2
| HGNCid = 18599
| Symbol = TUBGCP2
| AltSymbols =; GCP2; MGC138162; SPBC97; Spc97p
| OMIM = 
| ECnumber = 
| Homologene = 55980
| MGIid = 1921487
| GeneAtlas_image1 = PBB_GE_TUBGCP2_202477_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TUBGCP2_202476_s_at_tn.png
| Function =
| Component = {{GNF_GO|id=GO:0000922 |text = spindle pole}} {{GNF_GO|id=GO:0005815 |text = microtubule organizing center}} {{GNF_GO|id=GO:0005881 |text = cytoplasmic microtubule}}
| Process = {{GNF_GO|id=GO:0000226 |text = microtubule cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0007020 |text = microtubule nucleation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10844
    | Hs_Ensembl = ENSG00000130640
    | Hs_RefseqProtein = NP_006650
    | Hs_RefseqmRNA = NM_006659
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 134943125
    | Hs_GenLoc_end = 134975831
    | Hs_Uniprot = Q9BSJ2
    | Mm_EntrezGene = 74237
    | Mm_Ensembl = ENSMUSG00000025474
    | Mm_RefseqmRNA = NM_133755
    | Mm_RefseqProtein = NP_598516
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 139847316
    | Mm_GenLoc_end = 139887586
    | Mm_Uniprot = Q3TIB7
  }}
}}
'''Tubulin, gamma complex associated protein 2''', also known as '''TUBGCP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TUBGCP2 tubulin, gamma complex associated protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10844| accessdate = }}</ref>
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==References==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Hillman RT, Green RE, Brenner SE |title=An unappreciated role for RNA surveillance. |journal=Genome Biol. |volume=5 |issue= 2 |pages= R8 |year= 2005 |pmid= 14759258 |doi= 10.1186/gb-2004-5-2-r8 }}
*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Takahashi M, Yamagiwa A, Nishimura T, ''et al.'' |title=Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex. |journal=Mol. Biol. Cell |volume=13 |issue= 9 |pages= 3235-45 |year= 2003 |pmid= 12221128 |doi= 10.1091/mbc.E02-02-0112 }}
*{{cite journal  | author=Murphy SM, Preble AM, Patel UK, ''et al.'' |title=GCP5 and GCP6: two new members of the human gamma-tubulin complex. |journal=Mol. Biol. Cell |volume=12 |issue= 11 |pages= 3340-52 |year= 2002 |pmid= 11694571 |doi=  }}
*{{cite journal  | author=Murphy SM, Urbani L, Stearns T |title=The mammalian gamma-tubulin complex contains homologues of the yeast spindle pole body components spc97p and spc98p. |journal=J. Cell Biol. |volume=141 |issue= 3 |pages= 663-74 |year= 1998 |pmid= 9566967 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Adams MD, Kerlavage AR, Fleischmann RD, ''et al.'' |title=Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |journal=Nature |volume=377 |issue= 6547 Suppl |pages= 3-174 |year= 1995 |pmid= 7566098 |doi=  }}
}}
{{refend}}


{{protein-stub}}
{{gene-10-stub}}
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Latest revision as of 12:27, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Gamma-tubulin complex component 2 is a protein that in humans is encoded by the TUBGCP2 gene.[1][2] It is part of the gamma tubulin complex, which required for microtubule nucleation at the centrosome.

See also

References

  1. ↑ Murphy SM, Urbani L, Stearns T (Jun 1998). "The Mammalian γ-Tubulin Complex Contains Homologues of the Yeast Spindle Pole Body Components Spc97p and Spc98p". J Cell Biol. 141 (3): 663–74. doi:10.1083/jcb.141.3.663. PMC 2132743. PMID 9566967.
  2. ↑ "Entrez Gene: TUBGCP2 tubulin, gamma complex associated protein 2".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=TUBGCP2&oldid=1414347"