PEA15: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Astrocytic phosphoprotein PEA-15''' is a [[protein]] that in humans is encoded by the ''PEA15'' [[gene]].<ref name="pmid9205133">{{cite journal | vauthors = Hwang S, Kuo WL, Cochran JF, Guzman RC, Tsukamoto T, Bandyopadhyay G, Myambo K, Collins CC | title = Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers | journal = Genomics | volume = 42 | issue = 3 | pages = 540–2 | date = September 1997 | pmid = 9205133 | pmc = | doi = 10.1006/geno.1997.4768 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PEA15 phosphoprotein enriched in astrocytes 15| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8682| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the [[central nervous system]], particularly in [[astrocytes]].<ref name="entrez"/>
{{GNF_Protein_box
| image = PBB_Protein_PEA15_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1n3k.
| PDB = {{PDB2|1n3k}}
| Name = Phosphoprotein enriched in astrocytes 15
| HGNCid = 8822
| Symbol = PEA15
| AltSymbols =; MAT1; PED; HMAT1; HUMMAT1H; MAT1H; PEA-15
| OMIM = 603434
| ECnumber = 
| Homologene = 7884
| MGIid = 104799
| GeneAtlas_image1 = PBB_GE_PEA15_200788_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PEA15_200787_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005351 |text = sugar:hydrogen ion symporter activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}} {{GNF_GO|id=GO:0046325 |text = negative regulation of glucose import}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8682
    | Hs_Ensembl = ENSG00000162734
    | Hs_RefseqProtein = NP_003759
    | Hs_RefseqmRNA = NM_003768
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 158441751
    | Hs_GenLoc_end = 158451790
    | Hs_Uniprot = Q15121
    | Mm_EntrezGene = 18611
    | Mm_Ensembl = ENSMUSG00000013698
    | Mm_RefseqmRNA = NM_011063
    | Mm_RefseqProtein = NP_035193
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 174033404
    | Mm_GenLoc_end = 174043456
    | Mm_Uniprot = Q62048
  }}
}}
'''Phosphoprotein enriched in astrocytes 15''', also known as '''PEA15''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PEA15 phosphoprotein enriched in astrocytes 15| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8682| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
PEA-15 promotes autophagy in glioma cells in a JNK-dependent manner.<ref>{{cite journal | vauthors = Böck BC, Tagscherer KE, Fassl A, Krämer A, Oehme I, Zentgraf HW, Keith M, Roth W | title = The PEA-15 protein regulates autophagy via activation of JNK | journal = J. Biol. Chem. | volume = 285 | issue = 28 | pages = 21644–54 | date = July 2010 | pmid = 20452983 | pmc = 2898427 | doi = 10.1074/jbc.M109.096628 | url = http://www.jbc.org/cgi/pmidlookup?view=long&pmid=20452983 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text = PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PEA15 phosphoprotein enriched in astrocytes 15| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8682| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PEA15 has been shown to [[Protein-protein interaction|interact]] with:
* [[Caspase 8]],<ref name = pmid10493725>{{cite journal | vauthors = Kitsberg D, Formstecher E, Fauquet M, Kubes M, Cordier J, Canton B, Pan G, Rolli M, Glowinski J, Chneiweiss H | title = Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis | journal = J. Neurosci. | volume = 19 | issue = 19 | pages = 8244–51 | date = October 1999 | pmid = 10493725 | doi =  }}</ref><ref name = pmid10442631>{{cite journal | vauthors = Condorelli G, Vigliotta G, Cafieri A, Trencia A, Andalò P, Oriente F, Miele C, Caruso M, Formisano P, Beguinot F | title = PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis | journal = Oncogene | volume = 18 | issue = 31 | pages = 4409–15 | date = August 1999 | pmid = 10442631 | doi = 10.1038/sj.onc.1202831 }}</ref>
* [[FADD]],<ref name = pmid10493725/><ref name = pmid10442631/> and
* [[MAPK1]],<ref name = pmid11702783>{{cite journal | vauthors = Formstecher E, Ramos JW, Fauquet M, Calderwood DA, Hsieh JC, Canton B, Nguyen XT, Barnier JV, Camonis J, Ginsberg MH, Chneiweiss H | title = PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase | journal = Dev. Cell | volume = 1 | issue = 2 | pages = 239–50 | date = August 2001 | pmid = 11702783 | doi =  10.1016/s1534-5807(01)00035-1}}</ref>
* [[Phospholipase D1]],<ref name = pmid10926929>{{cite journal | vauthors = Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman MA | title = Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them | journal = J. Biol. Chem. | volume = 275 | issue = 45 | pages = 35224–32 | date = November 2000 | pmid = 10926929 | doi = 10.1074/jbc.M003329200 }}</ref>  and
* [[RPS6KA3]].<ref name = pmid12796492>{{cite journal | vauthors = Vaidyanathan H, Ramos JW | title = RSK2 activity is regulated by its interaction with PEA-15 | journal = J. Biol. Chem. | volume = 278 | issue = 34 | pages = 32367–72 | date = August 2003 | pmid = 12796492 | doi = 10.1074/jbc.M303988200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Araujo H, Danziger N, Cordier J, Glowinski J, Chneiweiss H | title = Characterization of PEA-15, a major substrate for protein kinase C in astrocytes | journal = J. Biol. Chem. | volume = 268 | issue = 8 | pages = 5911–20 | year = 1993 | pmid = 8449955 | doi =  }}
| citations =
* {{cite journal | vauthors = Estellés A, Yokoyama M, Nothias F, Vincent JD, Glowinski J, Vernier P, Chneiweiss H | title = The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human | journal = J. Biol. Chem. | volume = 271 | issue = 25 | pages = 14800–6 | year = 1996 | pmid = 8662970 | doi = 10.1074/jbc.271.25.14800 }}
*{{cite journal | author=Araujo H, Danziger N, Cordier J, ''et al.'' |title=Characterization of PEA-15, a major substrate for protein kinase C in astrocytes. |journal=J. Biol. Chem. |volume=268 |issue= 8 |pages= 5911-20 |year= 1993 |pmid= 8449955 |doi=  }}
* {{cite journal | vauthors = Condorelli G, Vigliotta G, Iavarone C, Caruso M, Tocchetti CG, Andreozzi F, Cafieri A, Tecce MF, Formisano P, Beguinot L, Beguinot F | title = PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus | journal = EMBO J. | volume = 17 | issue = 14 | pages = 3858–66 | year = 1998 | pmid = 9670003 | pmc = 1170721 | doi = 10.1093/emboj/17.14.3858 }}
*{{cite journal | author=Estellés A, Yokoyama M, Nothias F, ''et al.'' |title=The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 14800-6 |year= 1996 |pmid= 8662970 |doi= }}
* {{cite journal | vauthors = Kubes M, Cordier J, Glowinski J, Girault JA, Chneiweiss H | title = Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro | journal = J. Neurochem. | volume = 71 | issue = 3 | pages = 1307–14 | year = 1998 | pmid = 9721757 | doi = 10.1046/j.1471-4159.1998.71031307.x }}
*{{cite journal | author=Hwang S, Kuo WL, Cochran JF, ''et al.'' |title=Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers. |journal=Genomics |volume=42 |issue= 3 |pages= 540-2 |year= 1997 |pmid= 9205133 |doi= }}
* {{cite journal | vauthors = Condorelli G, Vigliotta G, Cafieri A, Trencia A, Andalò P, Oriente F, Miele C, Caruso M, Formisano P, Beguinot F | title = PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis | journal = Oncogene | volume = 18 | issue = 31 | pages = 4409–15 | year = 1999 | pmid = 10442631 | doi = 10.1038/sj.onc.1202831 }}
*{{cite journal | author=Condorelli G, Vigliotta G, Iavarone C, ''et al.'' |title=PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus. |journal=EMBO J. |volume=17 |issue= 14 |pages= 3858-66 |year= 1998 |pmid= 9670003 |doi= 10.1093/emboj/17.14.3858 }}
* {{cite journal | vauthors = Kitsberg D, Formstecher E, Fauquet M, Kubes M, Cordier J, Canton B, Pan G, Rolli M, Glowinski J, Chneiweiss H | title = Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis | journal = J. Neurosci. | volume = 19 | issue = 19 | pages = 8244–51 | year = 1999 | pmid = 10493725 | doi = }}
*{{cite journal | author=Kubes M, Cordier J, Glowinski J, ''et al.'' |title=Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro. |journal=J. Neurochem. |volume=71 |issue= 3 |pages= 1307-14 |year= 1998 |pmid= 9721757 |doi= }}
* {{cite journal | vauthors = Wolford JK, Bogardus C, Ossowski V, Prochazka M | title = Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians | journal = Gene | volume = 241 | issue = 1 | pages = 143–8 | year = 2000 | pmid = 10607908 | doi = 10.1016/S0378-1119(99)00455-2 }}
*{{cite journal | author=Condorelli G, Vigliotta G, Cafieri A, ''et al.'' |title=PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis. |journal=Oncogene |volume=18 |issue= 31 |pages= 4409-15 |year= 1999 |pmid= 10442631 |doi= 10.1038/sj.onc.1202831 }}
* {{cite journal | vauthors = Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman MA | title = Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them | journal = J. Biol. Chem. | volume = 275 | issue = 45 | pages = 35224–32 | year = 2001 | pmid = 10926929 | doi = 10.1074/jbc.M003329200 }}
*{{cite journal | author=Kitsberg D, Formstecher E, Fauquet M, ''et al.'' |title=Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis. |journal=J. Neurosci. |volume=19 |issue= 19 |pages= 8244-51 |year= 1999 |pmid= 10493725 |doi= }}
* {{cite journal | vauthors = Formstecher E, Ramos JW, Fauquet M, Calderwood DA, Hsieh JC, Canton B, Nguyen XT, Barnier JV, Camonis J, Ginsberg MH, Chneiweiss H | title = PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase | journal = Dev. Cell | volume = 1 | issue = 2 | pages = 239–50 | year = 2001 | pmid = 11702783 | doi = 10.1016/S1534-5807(01)00035-1 }}
*{{cite journal | author=Wolford JK, Bogardus C, Ossowski V, Prochazka M |title=Molecular characterization of the human PEA15 gene on 1q21-q22 and association with type 2 diabetes mellitus in Pima Indians. |journal=Gene |volume=241 |issue= 1 |pages= 143-8 |year= 2000 |pmid= 10607908 |doi= }}
* {{cite journal | vauthors = Condorelli G, Trencia A, Vigliotta G, Perfetti A, Goglia U, Cassese A, Musti AM, Miele C, Santopietro S, Formisano P, Beguinot F | title = Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function | journal = J. Biol. Chem. | volume = 277 | issue = 13 | pages = 11013–8 | year = 2002 | pmid = 11790785 | doi = 10.1074/jbc.M110934200 }}
*{{cite journal | author=Zhang Y, Redina O, Altshuller YM, ''et al.'' |title=Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 35224-32 |year= 2001 |pmid= 10926929 |doi= 10.1074/jbc.M003329200 }}
* {{cite journal | vauthors = Xiao C, Yang BF, Asadi N, Beguinot F, Hao C | title = Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells | journal = J. Biol. Chem. | volume = 277 | issue = 28 | pages = 25020–5 | year = 2002 | pmid = 11976344 | doi = 10.1074/jbc.M202946200 }}
*{{cite journal | author=Formstecher E, Ramos JW, Fauquet M, ''et al.'' |title=PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase. |journal=Dev. Cell |volume=1 |issue= 2 |pages= 239-50 |year= 2001 |pmid= 11702783 |doi= }}
* {{cite journal | vauthors = Vaidyanathan H, Ramos JW | title = RSK2 activity is regulated by its interaction with PEA-15 | journal = J. Biol. Chem. | volume = 278 | issue = 34 | pages = 32367–72 | year = 2003 | pmid = 12796492 | doi = 10.1074/jbc.M303988200 }}
*{{cite journal | author=Condorelli G, Trencia A, Vigliotta G, ''et al.'' |title=Multiple members of the mitogen-activated protein kinase family are necessary for PED/PEA-15 anti-apoptotic function. |journal=J. Biol. Chem. |volume=277 |issue= 13 |pages= 11013-8 |year= 2002 |pmid= 11790785 |doi= 10.1074/jbc.M110934200 }}
* {{cite journal | vauthors = Trencia A, Perfetti A, Cassese A, Vigliotta G, Miele C, Oriente F, Santopietro S, Giacco F, Condorelli G, Formisano P, Beguinot F | title = Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action | journal = Mol. Cell. Biol. | volume = 23 | issue = 13 | pages = 4511–21 | year = 2003 | pmid = 12808093 | pmc = 164852 | doi = 10.1128/MCB.23.13.4511-4521.2003 }}
*{{cite journal | author=Xiao C, Yang BF, Asadi N, ''et al.'' |title=Tumor necrosis factor-related apoptosis-inducing ligand-induced death-inducing signaling complex and its modulation by c-FLIP and PED/PEA-15 in glioma cells. |journal=J. Biol. Chem. |volume=277 |issue= 28 |pages= 25020-5 |year= 2002 |pmid= 11976344 |doi= 10.1074/jbc.M202946200 }}
* {{cite journal | vauthors = Trencia A, Fiory F, Maitan MA, Vito P, Barbagallo AP, Perfetti A, Miele C, Ungaro P, Oriente F, Cilenti L, Zervos AS, Formisano P, Beguinot F | title = Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15 | journal = J. Biol. Chem. | volume = 279 | issue = 45 | pages = 46566–72 | year = 2004 | pmid = 15328349 | doi = 10.1074/jbc.M406317200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Gaumont-Leclerc MF, Mukhopadhyay UK, Goumard S, Ferbeyre G | title = PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence | journal = J. Biol. Chem. | volume = 279 | issue = 45 | pages = 46802–9 | year = 2004 | pmid = 15331596 | doi = 10.1074/jbc.M403893200 }}
*{{cite journal | author=Vaidyanathan H, Ramos JW |title=RSK2 activity is regulated by its interaction with PEA-15. |journal=J. Biol. Chem. |volume=278 |issue= 34 |pages= 32367-72 |year= 2003 |pmid= 12796492 |doi= 10.1074/jbc.M303988200 }}
* {{cite journal | vauthors = Renganathan H, Vaidyanathan H, Knapinska A, Ramos JW | title = Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD | journal = Biochem. J. | volume = 390 | issue = Pt 3 | pages = 729–35 | year = 2006 | pmid = 15916534 | pmc = 1199667 | doi = 10.1042/BJ20050378 }}
*{{cite journal | author=Trencia A, Perfetti A, Cassese A, ''et al.'' |title=Protein kinase B/Akt binds and phosphorylates PED/PEA-15, stabilizing its antiapoptotic action. |journal=Mol. Cell. Biol. |volume=23 |issue= 13 |pages= 4511-21 |year= 2003 |pmid= 12808093 |doi= }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Trencia A, Fiory F, Maitan MA, ''et al.'' |title=Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46566-72 |year= 2004 |pmid= 15328349 |doi= 10.1074/jbc.M406317200 }}
*{{cite journal  | author=Gaumont-Leclerc MF, Mukhopadhyay UK, Goumard S, Ferbeyre G |title=PEA-15 is inhibited by adenovirus E1A and plays a role in ERK nuclear export and Ras-induced senescence. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 46802-9 |year= 2004 |pmid= 15331596 |doi= 10.1074/jbc.M403893200 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Renganathan H, Vaidyanathan H, Knapinska A, Ramos JW |title=Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD. |journal=Biochem. J. |volume=390 |issue= Pt 3 |pages= 729-35 |year= 2006 |pmid= 15916534 |doi= 10.1042/BJ20050378 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 17:53, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Astrocytic phosphoprotein PEA-15 is a protein that in humans is encoded by the PEA15 gene.[1][2]

PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the central nervous system, particularly in astrocytes.[2]

PEA-15 promotes autophagy in glioma cells in a JNK-dependent manner.[3]

Interactions

PEA15 has been shown to interact with:

References

  1. ↑ Hwang S, Kuo WL, Cochran JF, Guzman RC, Tsukamoto T, Bandyopadhyay G, Myambo K, Collins CC (September 1997). "Assignment of HMAT1, the human homolog of the murine mammary transforming gene (MAT1) associated with tumorigenesis, to 1q21.1, a region frequently gained in human breast cancers". Genomics. 42 (3): 540–2. doi:10.1006/geno.1997.4768. PMID 9205133.
  2. ↑ 2.0 2.1 "Entrez Gene: PEA15 phosphoprotein enriched in astrocytes 15".
  3. ↑ Böck BC, Tagscherer KE, Fassl A, Krämer A, Oehme I, Zentgraf HW, Keith M, Roth W (July 2010). "The PEA-15 protein regulates autophagy via activation of JNK". J. Biol. Chem. 285 (28): 21644–54. doi:10.1074/jbc.M109.096628. PMC 2898427. PMID 20452983.
  4. ↑ 4.0 4.1 Kitsberg D, Formstecher E, Fauquet M, Kubes M, Cordier J, Canton B, Pan G, Rolli M, Glowinski J, Chneiweiss H (October 1999). "Knock-out of the neural death effector domain protein PEA-15 demonstrates that its expression protects astrocytes from TNFalpha-induced apoptosis". J. Neurosci. 19 (19): 8244–51. PMID 10493725.
  5. ↑ 5.0 5.1 Condorelli G, Vigliotta G, Cafieri A, Trencia A, Andalò P, Oriente F, Miele C, Caruso M, Formisano P, Beguinot F (August 1999). "PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis". Oncogene. 18 (31): 4409–15. doi:10.1038/sj.onc.1202831. PMID 10442631.
  6. ↑ Formstecher E, Ramos JW, Fauquet M, Calderwood DA, Hsieh JC, Canton B, Nguyen XT, Barnier JV, Camonis J, Ginsberg MH, Chneiweiss H (August 2001). "PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase". Dev. Cell. 1 (2): 239–50. doi:10.1016/s1534-5807(01)00035-1. PMID 11702783.
  7. ↑ Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, Frohman MA (November 2000). "Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them". J. Biol. Chem. 275 (45): 35224–32. doi:10.1074/jbc.M003329200. PMID 10926929.
  8. ↑ Vaidyanathan H, Ramos JW (August 2003). "RSK2 activity is regulated by its interaction with PEA-15". J. Biol. Chem. 278 (34): 32367–72. doi:10.1074/jbc.M303988200. PMID 12796492.

Further reading

  • Araujo H, Danziger N, Cordier J, Glowinski J, Chneiweiss H (1993). "Characterization of PEA-15, a major substrate for protein kinase C in astrocytes". J. Biol. Chem. 268 (8): 5911–20. PMID 8449955.
  • Estellés A, Yokoyama M, Nothias F, Vincent JD, Glowinski J, Vernier P, Chneiweiss H (1996). "The major astrocytic phosphoprotein PEA-15 is encoded by two mRNAs conserved on their full length in mouse and human". J. Biol. Chem. 271 (25): 14800–6. doi:10.1074/jbc.271.25.14800. PMID 8662970.
  • Condorelli G, Vigliotta G, Iavarone C, Caruso M, Tocchetti CG, Andreozzi F, Cafieri A, Tecce MF, Formisano P, Beguinot L, Beguinot F (1998). "PED/PEA-15 gene controls glucose transport and is overexpressed in type 2 diabetes mellitus". EMBO J. 17 (14): 3858–66. doi:10.1093/emboj/17.14.3858. PMC 1170721. PMID 9670003.
  • Kubes M, Cordier J, Glowinski J, Girault JA, Chneiweiss H (1998). "Endothelin induces a calcium-dependent phosphorylation of PEA-15 in intact astrocytes: identification of Ser104 and Ser116 phosphorylated, respectively, by protein kinase C and calcium/calmodulin kinase II in vitro". J. Neurochem. 71 (3): 1307–14. doi:10.1046/j.1471-4159.1998.71031307.x. PMID 9721757.
  • Condorelli G, Vigliotta G, Cafieri A, Trencia A, Andalò P, Oriente F, Miele C, Caruso M, Formisano P, Beguinot F (1999). "PED/PEA-15: an anti-apoptotic molecule that regulates FAS/TNFR1-induced apoptosis". Oncogene. 18 (31): 4409–15. doi:10.1038/sj.onc.1202831. PMID 10442631.
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