Klebsiella granulomatis: Difference between revisions

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==Overview==
==Overview==
''Klebsiella granulomatis'', originally classified as ''Calymmatobacterium granulomatis'',  is a fastidious [[Gram-negative]] [[pleomorphic]] bacteria causing donovanosis, a [[gential ulcer disease]].
==Organism==
*Aragão and Vianna classified the bacteria causing donovanosis as ''Calymmatobacterium granulomatis'' in 1913. However, DNA sequencing of 16S rRNA and ''phoE'' genes revealed similarity to ''Klebsiella''.<ref name="VelhoSouza2008">{{cite journal|last1=Velho|first1=Paulo Eduardo Neves Ferreira|last2=Souza|first2=Elemir Macedo de|last3=Belda Junior|first3=Walter|title=Donovanosis|journal=Brazilian Journal of Infectious Diseases|volume=12|issue=6|year=2008|issn=1413-8670|doi=10.1590/S1413-86702008000600015}}</ref>
:*There is 99% homology between the etiologic agent of donovanosis and members of ''Klebsiella''.<ref name="pmid9350758">{{cite journal| author=Carter J, Hutton S, Sriprakash KS, Kemp DJ, Lum G, Savage J et al.| title=Culture of the causative organism of donovanosis (Calymmatobacterium granulomatis) in HEp-2 cells. | journal=J Clin Microbiol | year= 1997 | volume= 35 | issue= 11 | pages= 2915-7 | pmid=9350758 | doi= | pmc=PMC230086 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9350758  }} </ref>
:*A proposal has been put forth to reclassify the bacteria to ''Klebsiella granulomatis''.
*''K. granulomatis'' morphology:<ref name="Richens">{{cite journal| author=Richens J| title=The diagnosis and treatment of donovanosis (granuloma inguinale). | journal=Genitourin Med | year= 1991 | volume= 67 | issue= 6 | pages= 441-52 | pmid=1774048 | doi= | pmc=PMC1194766 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1774048  }} </ref>
:*[[Pleomorphic]] ranging from [[coccus]] to [[bacillus]]
:*1-2 X 0.5-0.7 μm
:*May or may not be capsulated
:*Non-motile
==Human Pathogen==
*''K. granulomatis'' is an [[obligate]], intracellular human [[pathogen]].
*''K. granulomatis'' is typically transmitted through sexual contact but may also be transmitted through direct contact and fecal contamination.<ref name=" O'Farrell">{{cite journal| author=O'Farrell N| title=Donovanosis. | journal=Sex Transm Infect | year= 2002 | volume= 78 | issue= 6 | pages= 452-7 | pmid=12473810 | doi= | pmc=PMC1758360 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12473810  }} </ref>
==Gallery==
<gallery>
Image: Granuloma inguinale12.jpeg| This image reveals some of the cytoarchitectural features seen in a lymph node specimen that had been extracted from a patient suspected of a Hantavirus illness. Note the concentration of lymphohistiocytic infiltrates, almost all cases have expanded paracortical regions, or T-cell regions with immunoblasts, which sometimes extend into the cortex and into the medulla. <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
Image: Enterobacteria28.jpeg|  “Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
Image: Enterobacteria56.jpeg|  “Donovan bodies” in a tissue sample used to diagnose granuloma inguinale. <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
Image: Enterobacteria27.jpeg|  Dieterle’s silver stain under photomicrographic examination, image reveals presence of numerous Donovan bodies. <SMALL><SMALL>''[http://phil.cdc.gov/phil/home.asp From Public Health Image Library (PHIL).] ''<ref name=PHIL> {{Cite web | title = Public Health Image Library (PHIL) | url = http://phil.cdc.gov/phil/home.asp}}</ref></SMALL></SMALL>
</gallery>


==References==
==References==
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[[Category:Sexually transmitted infections]]
[[Category:Sexually transmitted infections]]
[[Category:Bacterial diseases]]
[[Category:Bacterial diseases]]
[[Category:Infectious disease]]
 
[[Category:Disease]]
[[Category:Disease]]
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[[Category:Needs content]]

Latest revision as of 18:08, 18 September 2017

Donovanosis Microchapters

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This page is about microbiologic aspects of the organism(s).  For clinical aspects of the disease, see Donovanosis.

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nate Michalak, B.A.;


Overview

Klebsiella granulomatis, originally classified as Calymmatobacterium granulomatis, is a fastidious Gram-negative pleomorphic bacteria causing donovanosis, a gential ulcer disease.

Organism

  • Aragão and Vianna classified the bacteria causing donovanosis as Calymmatobacterium granulomatis in 1913. However, DNA sequencing of 16S rRNA and phoE genes revealed similarity to Klebsiella.[1]
  • There is 99% homology between the etiologic agent of donovanosis and members of Klebsiella.[2]
  • A proposal has been put forth to reclassify the bacteria to Klebsiella granulomatis.
  • K. granulomatis morphology:[3]

Human Pathogen

  • K. granulomatis is an obligate, intracellular human pathogen.
  • K. granulomatis is typically transmitted through sexual contact but may also be transmitted through direct contact and fecal contamination.[4]

Gallery

References

  1. Velho, Paulo Eduardo Neves Ferreira; Souza, Elemir Macedo de; Belda Junior, Walter (2008). "Donovanosis". Brazilian Journal of Infectious Diseases. 12 (6). doi:10.1590/S1413-86702008000600015. ISSN 1413-8670.
  2. Carter J, Hutton S, Sriprakash KS, Kemp DJ, Lum G, Savage J; et al. (1997). "Culture of the causative organism of donovanosis (Calymmatobacterium granulomatis) in HEp-2 cells". J Clin Microbiol. 35 (11): 2915–7. PMC 230086. PMID 9350758.
  3. Richens J (1991). "The diagnosis and treatment of donovanosis (granuloma inguinale)". Genitourin Med. 67 (6): 441–52. PMC 1194766. PMID 1774048.
  4. O'Farrell N (2002). "Donovanosis". Sex Transm Infect. 78 (6): 452–7. PMC 1758360. PMID 12473810.
  5. 5.0 5.1 5.2 5.3 "Public Health Image Library (PHIL)".


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