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==Overview==
==Overview==
The incidence of Japanese encephalitis in patients younger than 19 years old is approximately 10-100 per 100,000 individuals worldwide. The case-fatality rate of Japanese encephalitis is approximately 20-30% worldwide. Japanese encephalitis more commonly affects individuals younger than 18 years of age. Japanese encephalitis usually affects individuals of the Asian race. Japanese encephalitis is most commonly observed in the summer months within temperate climate zones. Japanese encephalitis is a common disease that tends to affect approximately 30,000 to 70,000 individuals in Asia annually.


==Epidemiology and Demographics==
==Epidemiology and Demographics==
===Prevalence===
===Prevalence===
There are 24 countries in Southeast Asia and Western Pacific regions that have Japanese encephalitis virus transmission risk, a population of over 3 billion people.
There are 24 countries in Southeast Asia and Western Pacific regions that have Japanese encephalitis virus transmission risk, a population of over 3 billion people.<ref name=WHOJaEncephFact> Japanese encephalitis - Fact sheet No 386. World Health Organization (WHO) (2015) http://www.who.int/mediacentre/factsheets/fs386/en/ Accessed on April 12, 2016</ref>


===Incidence===
===Incidence===
The incidence of Japanese encephalitis in patients younger than 19 years old is approximately 10-100 per 100,000 individuals worldwide.<ref name="pmid19527110">{{cite journal| author=Kollaritsch H, Paulke-Korinek M, Dubischar-Kastner K| title=IC51 Japanese encephalitis vaccine. | journal=Expert Opin Biol Ther | year= 2009 | volume= 9 | issue= 7 | pages= 921-31 | pmid=19527110 | doi=10.1517/14712590903042282 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19527110  }} </ref>
The incidence of Japanese encephalitis in patients younger than 19 years old is approximately 10-100 per 100,000 individuals worldwide.<ref name="pmid19527110">{{cite journal| author=Kollaritsch H, Paulke-Korinek M, Dubischar-Kastner K| title=IC51 Japanese encephalitis vaccine. | journal=Expert Opin Biol Ther | year= 2009 | volume= 9 | issue= 7 | pages= 921-31 | pmid=19527110 | doi=10.1517/14712590903042282 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19527110  }} </ref>
===Developed Countries===
Japanese encephalitis is a rare disease that tends to sporadically cause [[outbreak]]s which affect U.S. territories in the Western Pacific.
===Developing Countries===
Japanese encephalitis is a common disease that tends to affect approximately 30,000 to 70,000 individuals in Asia annually.<ref name=WHOJaEncephFact> Japanese encephalitis - Fact sheet No 386. World Health Organization (WHO) (2015) http://www.who.int/mediacentre/factsheets/fs386/en/ Accessed on April 12, 2016</ref>


===Case-Fatality Rate===
===Case-Fatality Rate===
Line 22: Line 17:


===Age===
===Age===
 
Japanese encephalitis more commonly affects individuals younger than 18 years of age. In rural areas where Japanese encephalitis is [[endemic]], seroprevalance approaches 100%; approximately 1 in 300 infected children develop Japanese encephalitis.<ref name="pmid23235298">{{cite journal| author=Centers for Disease Control and Prevention (CDC)| title=Expanding poliomyelitis and measles surveillance networks to establish surveillance for acute meningitis and encephalitis syndromes--Bangladesh, China, and India, 2006-2008. | journal=MMWR Morb Mortal Wkly Rep | year= 2012 | volume= 61 | issue= 49 | pages= 1008-11 | pmid=23235298 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23235298  }} </ref>


===Race===
===Race===
Japanese encephalitis usually affects individuals of the Asian race.


===Seasonal===
Japanese encephalitis is most commonly observed in the summer months within temperate climate zones. Year-round transmission is observed in tropical climate zones.<ref name="pmid1337744">{{cite journal| author=Vaughn DW, Hoke CH| title=The epidemiology of Japanese encephalitis: prospects for prevention. | journal=Epidemiol Rev | year= 1992 | volume= 14 | issue=  | pages= 197-221 | pmid=1337744 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1337744  }} </ref>


===Geographical Location===
 
The majority of Japanese encephalitis cases are reported in South and Southeast Asia. There have been suspected cases on the Indian subcontinent.
*Leading cause of viral encephalitis in Asia with 30-50,000 cases reported annually
*Fewer than 1 case/year in U.S. civilians and military personnel traveling to and living in Asia


The disease is [[endemic]] with seasonal distribution in temperate climate zones of Asia as well as South and South-East Asia. All year transmission is observed in tropical climate zones. Currently, JE is considered hyperendemic in parts of India and Nepal, where authorities have responded with immunization campaigns. Countries which have had major [[epidemic]]s in the past, but which have controlled the disease primarily by [[vaccination]], include China, Korea, Japan, Taiwan and Thailand. Other countries that still have periodic epidemics include Viet Nam, Cambodia, Myanmar, India, Nepal, and Malaysia.  
===Developed Countries===
 
Japanese encephalitis is a rare disease that tends to sporadically cause [[outbreak]]s which affect U.S. territories in the Western Pacific.  
Large outbreaks of JE with clear summer seasonality<ref name="pmid1337744">{{cite journal| author=Vaughn DW, Hoke CH| title=The epidemiology of Japanese encephalitis: prospects for prevention. | journal=Epidemiol Rev | year= 1992 | volume= 14 | issue=  | pages= 197-221 | pmid=1337744 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1337744  }} </ref> also are periodically reported on the Indian subcontinent, as illustrated in Uttar Pradash, where 6097 suspected cases, including 1398 deaths, were reported between July 1 and November 10, 2005.


===Developing Countries===
Japanese encephalitis is a common disease that tends to affect approximately 30,000 to 70,000 individuals in Asia annually.<ref name=WHOJaEncephFact> Japanese encephalitis - Fact sheet No 386. World Health Organization (WHO) (2015) http://www.who.int/mediacentre/factsheets/fs386/en/ Accessed on April 12, 2016</ref>
[[Image:Japanese Encephalitis 1100px 734px CNV.jpg|center|thumb|500px|Map: areas where Japanese encephalitis is [[endemic]]]]
[[Image:Japanese Encephalitis 1100px 734px CNV.jpg|center|thumb|500px|Map: areas where Japanese encephalitis is [[endemic]]]]
[[Image:Table japanese encephalitis.jpg|center|frame|Risk of Japanese encephalitis by country, region, and season]]
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[[Image:Table japanese encephalitis 2.jpg|center|frame|Risk of Japanese encephalitis by country, region, and season--continued]]
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==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
   
   
[[Category:Viruses]]
[[Category:FinalQCRequired]]
[[Category:Neurology]]
[[Category:Neurology]]
[[Category:Infectious disease]]


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Latest revision as of 18:06, 18 September 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anthony Gallo, B.S. [2]

Overview

The incidence of Japanese encephalitis in patients younger than 19 years old is approximately 10-100 per 100,000 individuals worldwide. The case-fatality rate of Japanese encephalitis is approximately 20-30% worldwide. Japanese encephalitis more commonly affects individuals younger than 18 years of age. Japanese encephalitis usually affects individuals of the Asian race. Japanese encephalitis is most commonly observed in the summer months within temperate climate zones. Japanese encephalitis is a common disease that tends to affect approximately 30,000 to 70,000 individuals in Asia annually.

Epidemiology and Demographics

Prevalence

There are 24 countries in Southeast Asia and Western Pacific regions that have Japanese encephalitis virus transmission risk, a population of over 3 billion people.[1]

Incidence

The incidence of Japanese encephalitis in patients younger than 19 years old is approximately 10-100 per 100,000 individuals worldwide.[2]

Case-Fatality Rate

The case-fatality rate of Japanese encephalitis is approximately 20-30% worldwide.[3]

Age

Japanese encephalitis more commonly affects individuals younger than 18 years of age. In rural areas where Japanese encephalitis is endemic, seroprevalance approaches 100%; approximately 1 in 300 infected children develop Japanese encephalitis.[4]

Race

Japanese encephalitis usually affects individuals of the Asian race.

Seasonal

Japanese encephalitis is most commonly observed in the summer months within temperate climate zones. Year-round transmission is observed in tropical climate zones.[5]

Geographical Location

The majority of Japanese encephalitis cases are reported in South and Southeast Asia. There have been suspected cases on the Indian subcontinent.

Developed Countries

Japanese encephalitis is a rare disease that tends to sporadically cause outbreaks which affect U.S. territories in the Western Pacific.

Developing Countries

Japanese encephalitis is a common disease that tends to affect approximately 30,000 to 70,000 individuals in Asia annually.[1]

Map: areas where Japanese encephalitis is endemic

References

  1. 1.0 1.1 Japanese encephalitis - Fact sheet No 386. World Health Organization (WHO) (2015) http://www.who.int/mediacentre/factsheets/fs386/en/ Accessed on April 12, 2016
  2. Kollaritsch H, Paulke-Korinek M, Dubischar-Kastner K (2009). "IC51 Japanese encephalitis vaccine". Expert Opin Biol Ther. 9 (7): 921–31. doi:10.1517/14712590903042282. PMID 19527110.
  3. Japanese encephalitis - Frequently Asked Questions. CDC Centers for Disease Control and Prevention. (2015) http://www.cdc.gov/japaneseencephalitis/qa/index.html Accessed on April 12, 2016
  4. Centers for Disease Control and Prevention (CDC) (2012). "Expanding poliomyelitis and measles surveillance networks to establish surveillance for acute meningitis and encephalitis syndromes--Bangladesh, China, and India, 2006-2008". MMWR Morb Mortal Wkly Rep. 61 (49): 1008–11. PMID 23235298.
  5. Vaughn DW, Hoke CH (1992). "The epidemiology of Japanese encephalitis: prospects for prevention". Epidemiol Rev. 14: 197–221. PMID 1337744.


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