Chikungunya laboratory findings: Difference between revisions

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==Overview==
There are no pathognomonic laboratory findings for Chikungunya virus infection. Laboratory abnormalities include mild [[thrombocytopenia]] (>100,000/mm<sup>3</sup>), [[neutropenia]], [[lymphopenia]], and elevated [[liver function test]]s. [[ESR|Erythrocyte sedimentation rate]] and [[CRP|C-reactive protein]] are usually elevated.<ref name=PAHO2011>{{cite book | last = | first = | title = Preparedness and response for Chikungunya virus introduction in the Americas | publisher = Pan American Health Organization CDC, Center for Disease Control and Prevention | location = Washington, DC | year = 2011 | isbn = 978-92-75-11632-6 }}</ref>


==Laboratory Findings==
==Laboratory Findings==


* Clinical laboratory findings can include [[lymphopenia]], [[thrombocytopenia]], elevated [[creatinine]], and elevated [[hepatic transaminases]].
Laboratory abnormalities include the followings:<ref name=PAHO2011>{{cite book | last = | first = | title = Preparedness and response for Chikungunya virus introduction in the Americas | publisher = Pan American Health Organization CDC, Center for Disease Control and Prevention | location = Washington, DC | year = 2011 | isbn = 978-92-75-11632-6 }}</ref>
* Laboratory diagnosis is generally accomplished by testing serum or plasma to detect [[virus]], viral nucleic acid, or virus-specific [[immunoglobulin]] (Ig) M and neutralizing [[antibodies]].
 
* [[Viral culture]] may detect [[virus]] in the first 3 days of illness; however, chikungunya [[virus]] should be handled under biosafety level (BSL) 3 conditions.
* Mild [[thrombocytopenia]] (>100,000/mm<sup>3</sup>)
* During the first 8 days of illness, chikungunya [[viral]] [[RNA]] can often be identified in serum.
* [[Leukopenia]] (including [[neutropenia]] and [[lymphopenia]])
* Chikungunya [[virus]] [[antibodies]] normally develop toward the end of the first week of illness. Therefore, to definitively rule out the diagnosis, convalescent-phase samples should be obtained from patients whose acute-phase samples test negative.
* Elevated [[AST]] and/or [[ALT]]
* Chikungunya [[virus]] testing is performed at CDC, a few state health departments, and one commercial laboratory.
* Elevated [[ESR|erythrocyte sedimentation rate (ESR)]]  
* Test results are normally available 4 to 14 days after specimen receipt.
* Elevated [[CRP|C-reactive protein (CRP)]]
* Reporting times for test results may be longer during summer months when [[arbovirus]] activity increases.
* Receipt of a hard copy of the results will take at least 2 weeks after testing is completed.
* Initial [[serological testing]] will be performed using IgM-capture [[ELISA]] and IgG [[ELISA]]. If the initial results are positive, further confirmatory testing will be performed and it may delay the reporting of final results.


==References==
==References==
{{reflist|2}}
==External Links==
* [http://www.cdc.gov/Chikungunya/index.html CDC Chikungunya virus]
* [http://www.cdc.gov/Chikungunya/index.html CDC Chikungunya virus]


{{Reflist|2}}
[[Category:Disease]]


[[Category:Disease]]
[[Category:Infectious disease]]
[[Category:Viral diseases]]
[[Category:Viral diseases]]
[[Category:Togaviruses]]
[[Category:Togaviruses]]
[[Category:Tropical disease]]
[[Category:Tropical disease]]
[[Category:Needs overview]]
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Latest revision as of 17:23, 18 September 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alejandro Lemor, M.D. [2], Alonso Alvarado, M.D. [3]

Overview

There are no pathognomonic laboratory findings for Chikungunya virus infection. Laboratory abnormalities include mild thrombocytopenia (>100,000/mm3), neutropenia, lymphopenia, and elevated liver function tests. Erythrocyte sedimentation rate and C-reactive protein are usually elevated.[1]

Laboratory Findings

Laboratory abnormalities include the followings:[1]

References

  1. 1.0 1.1 Preparedness and response for Chikungunya virus introduction in the Americas. Washington, DC: Pan American Health Organization CDC, Center for Disease Control and Prevention. 2011. ISBN 978-92-75-11632-6.

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