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==Staging==
===Discovery===
The breast cancer stage is based on the results of testing that is done on the tumor and lymph nodes removed during surgery and other tests.
*The oldest evidence of cancer is discovered in the Egyptian literature and dates back to about 3000 BC. The textbook is called the 'Edwin Smith Papyrus' and describes 8 cases of tumors of the breast that were removed by [[cauterization]] with a tool called the fire drill. The writing says about the disease, “There is no treatment.”<ref>{{cite web
===Stage 0===
  | title = The History of Cancer
There are 3 types of breast carcinoma in situ:
  | work = [[American Cancer Society]]
*Ductal carcinoma in situ (DCIS) is a noninvasive condition in which abnormal cells are found in the lining of a breast duct. The abnormal cells have not spread outside the duct to other tissues in the breast. In some cases, DCIS may become invasive cancer and spread to other tissues. At this time, there is no way to know which lesions could become invasive.
  | date = 2002-03-25
*Lobular carcinoma in situ (LCIS) is a condition in which abnormal cells are found in the lobules of the breast. This condition seldom becomes invasive cancer.
  | url = http://www.cancer.org/docroot/CRI/content/CRI_2_6x_the_history_of_cancer_72.asp?sitearea=CRI
*Paget disease of the nipple is a condition in which abnormal cells are found in the nipple only.
  | accessdate = 2006-10-09 }}</ref>
===Stage 1===
===Landmark Events in the Development of Treatment Strategies===
In stage I, cancer has formed. Stage I is divided into stages IA and IB.
*In 1761, Giovanni Morgagni of Padua became the first to perform an autopsy to relate the illness to the pathology.
*In stage IA, the tumor is 2 centimeters or smaller. Cancer has not spread outside the breast.
* The Scottish surgeon John Hunter (1728-1793) suggested that cancer could be removed if tumor had not invaded nearby tissue and was 'moveable'.
*In stage IB, small clusters of breast cancer cells (larger than 0.2 millimeter but not larger than 2 millimeters) are found in the lymph nodes and either:
*In 1700s, John Hunter, the Scottish surgeon suggested that tumors grow from lymph constantly thrown out by the blood.
:*no tumor is found in the breast; or
*In 19th century, Rudolf Virchow became the first to correlate the illness to microscopic pathology.
:*the tumor is 2 centimeters or smaller.
*Zacutus Lusitani (1575-1642) and Nicholas Tulp (1593-1674), 2 doctors in Holland, publicized their work in 1649 and 1652 respectively that concluded that breast cancer was contagious based on their observation of the tumor in the members of the same household.
===Stage II===
*In the 1990s, BRCA1 and BRCA2 genes were associated with development of breast cancer for first time.  
Stage II is divided into stages IIA and IIB.
*In 1713, Bernardino Ramazzini, an Italian doctor, reported the relatively high incidence of breast cancer in nuns. This observation made it a clear association between breast cancer and role of hormones.
*In stage IIA:
*In late 1960s, modern mammography methods were developed.
:*no tumor is found in the breast or the tumor is 2 centimeters or smaller. Cancer (larger than 2 millimeters) is found in 1 to 3 axillary lymph nodes or in the lymph nodes near the breastbone (found during a sentinel lymph node biopsy); or
*In 1976, mammography became officially recommended by the American cancer society.
:*the tumor is larger than 2 centimeters but not larger than 5 centimeters. Cancer has not spread to the lymph nodes.
*In the last decade of the 19th century, William Stewart Halsted, professor of surgery at Johns Hopkins University, came up with the radical mastectomy procedure.
*In stage IIB, the tumor is:
*In 1719, Lorenz Heister, a German surgeon wrote about his ideas for mastectomy and lumpectomy in his book, Chirurgie.
:*larger than 2 centimeters but not larger than 5 centimeters. Small clusters of breast cancer cells (larger than 0.2 millimeter but not larger than 2 millimeters) are found in the lymph nodes; or
*In 1896, Thomas Beatson, a graduate from the University of Edinburgh, described the relationship between oophorectomy and breast cancer. This study laid down the foundation of the hormonal therapy of the breast cancer.
:*larger than 2 centimeters but not larger than 5 centimeters. Cancer has spread to 1 to 3 axillary lymph nodes or to the lymph nodes near the breastbone (found during a sentinel lymph node biopsy); or
*In the 1970s, modern clinical trials demonstrated that less extensive surgery is equally effective for most women with breast cancer.
:*larger than 5 centimeters. Cancer has not spread to the lymph nodes.
*During the final decades of the 20th century, technices were developed to minimizing the amount of normal tissue removed along with the tumor.
===Stage III===
*In late 1990s, first therapeutic monoclonal antibodies, trastuzumab (Herceptin) was approved for breast cancer.
Stage III is divided into IIIA, IIIB, and IIIC.
*Stage IIIA
:*no tumor is found in the breast or the tumor may be any size. Cancer is found in 4 to 9 axillary lymph nodes or in the lymph nodes near the breastbone (found during imaging tests or a physical exam); or
:*the tumor is larger than 5 centimeters. Small clusters of breast cancer cells (larger than 0.2 millimeter but not larger than 2 millimeters) are found in the lymph nodes; or
:*the tumor is larger than 5 centimeters. Cancer has spread to 1 to 3 axillary lymph nodes or to the lymph nodes near the breastbone (found during a sentinel lymph node biopsy).
*Stage IIIB
:*the tumor may be any size and cancer has spread to the chest wall and/or to the skin of the breast and caused swelling or an ulcer.  
:*cancer may have spread to:
::*up to 9 axillary lymph nodes; or
::*the lymph nodes near the breastbone
*Stage IIIC
:*no tumor is found in the breast or the tumor may be any size. Cancer may have spread to the skin of the breast and caused swelling or an ulcer and/or has spread to the chest wall.
:*cancer has spread to:
::*10 or more axillary lymph nodes; or
::*lymph nodes above or below the collarbone; or
::*axillary lymph nodes and lymph nodes near the breastbone
:*For treatment, stage IIIC breast cancer is divided into operable and inoperable stage IIIC.
===Stage IV===
*In stage IV, cancer has spread to other organs of the body, most often the bones, lungs, liver, or brain.
 
===Inflammatory Breast Cancer===
*In inflammatory breast cancer, cancer has spread to the skin of the breast and the breast looks red and swollen and feels warm. The redness and warmth occur because the cancer cells block the lymph vessels in the skin. The skin of the breast may also show the dimpled appearance called peau d’orange (like the skin of an orange). There may not be any lumps in the breast that can be felt.  
*Inflammatory breast cancer may be stage IIIB, stage IIIC, or stage IV.

Latest revision as of 21:50, 23 January 2016

Discovery

  • The oldest evidence of cancer is discovered in the Egyptian literature and dates back to about 3000 BC. The textbook is called the 'Edwin Smith Papyrus' and describes 8 cases of tumors of the breast that were removed by cauterization with a tool called the fire drill. The writing says about the disease, “There is no treatment.”[1]

Landmark Events in the Development of Treatment Strategies

  • In 1761, Giovanni Morgagni of Padua became the first to perform an autopsy to relate the illness to the pathology.
  • The Scottish surgeon John Hunter (1728-1793) suggested that cancer could be removed if tumor had not invaded nearby tissue and was 'moveable'.
  • In 1700s, John Hunter, the Scottish surgeon suggested that tumors grow from lymph constantly thrown out by the blood.
  • In 19th century, Rudolf Virchow became the first to correlate the illness to microscopic pathology.
  • Zacutus Lusitani (1575-1642) and Nicholas Tulp (1593-1674), 2 doctors in Holland, publicized their work in 1649 and 1652 respectively that concluded that breast cancer was contagious based on their observation of the tumor in the members of the same household.
  • In the 1990s, BRCA1 and BRCA2 genes were associated with development of breast cancer for first time.
  • In 1713, Bernardino Ramazzini, an Italian doctor, reported the relatively high incidence of breast cancer in nuns. This observation made it a clear association between breast cancer and role of hormones.
  • In late 1960s, modern mammography methods were developed.
  • In 1976, mammography became officially recommended by the American cancer society.
  • In the last decade of the 19th century, William Stewart Halsted, professor of surgery at Johns Hopkins University, came up with the radical mastectomy procedure.
  • In 1719, Lorenz Heister, a German surgeon wrote about his ideas for mastectomy and lumpectomy in his book, Chirurgie.
  • In 1896, Thomas Beatson, a graduate from the University of Edinburgh, described the relationship between oophorectomy and breast cancer. This study laid down the foundation of the hormonal therapy of the breast cancer.
  • In the 1970s, modern clinical trials demonstrated that less extensive surgery is equally effective for most women with breast cancer.
  • During the final decades of the 20th century, technices were developed to minimizing the amount of normal tissue removed along with the tumor.
  • In late 1990s, first therapeutic monoclonal antibodies, trastuzumab (Herceptin) was approved for breast cancer.
  1. "The History of Cancer". American Cancer Society. 2002-03-25. Retrieved 2006-10-09.