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{{Taxobox
{{DrugProjectFormSinglePage
| color = lightgreen
|authorTag=<!--Overview-->{{RB}}
| name = Ipecacuanha
|OTC=Yes
| image = Koeh-251.jpg
|genericName=Ipecacuanha
| image_width = 250px
|aOrAn=a
| regnum = [[Plant]]ae
|drugClass=OTC emetic
| divisio = [[Flowering plant|Magnoliophyta]]
|indicationType=treatment
| classis = [[Magnoliopsida]]
|indication= of [[Poisoning]], acute by inducing [[vomiting]]
| ordo = [[Rubiales]]
|adverseReactions=[[Diarrhea]], [[Stomach cramps]], [[Myalgia]] and [[Lethargy]]
| familia = [[Rubiaceae]]
 
| genus = ''[[Psychotria]]''
 
| species = '''''P. ipecacuanha'''''
<!--Black Box Warning-->
| binomial = ''Psychotria ipecacuanha''
|blackBoxWarningTitle=<span style="color:#FF0000;">ConditionName: </span>
}}
|blackBoxWarningBody=<i><span style="color:#FF0000;">ConditionName: </span></i>
 
 
 
<!--Adult Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Adult)-->
|fdaLIADAdult=====Indications====
* [[Poisoning]], acute<ref name="pmid2865374">{{cite journal| author=Krenzelok EP, Dean BS| title=Syrup of ipecac in children less than one year of age. | journal=J Toxicol Clin Toxicol | year= 1985 | volume= 23 | issue= 2-3 | pages= 171-6 | pmid=2865374 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2865374  }} </ref><ref name="pmid2900493">{{cite journal| author=Litovitz T| title=In defense of retaining ipecac syrup as an over-the-counter drug. | journal=Pediatrics | year= 1988 | volume= 82 | issue= 3 Pt 2 | pages= 514-6 | pmid=2900493 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2900493  }} </ref>
* to induce [[NAUSEA]] AND [[VOMITING]]
 
====Dosage====
=====(Adults / Children 2-18 years)=====
* Allow 3 or 4 pellets to dissolve in the mouth 3 times a day until symptoms are relieved or as directed by a health professional.
|offLabelAdultGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
 
<!--Non–Guideline-Supported Use (Adult)-->
|offLabelAdultNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in adult patients.
 
<!--Pediatric Indications and Dosage-->
 
<!--FDA-Labeled Indications and Dosage (Pediatric)-->
|fdaLIADPed=====Indications====
* Poisoning, acute<ref name="pmid2865374">{{cite journal| author=Krenzelok EP, Dean BS| title=Syrup of ipecac in children less than one year of age. | journal=J Toxicol Clin Toxicol | year= 1985 | volume= 23 | issue= 2-3 | pages= 171-6 | pmid=2865374 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2865374  }} </ref>
 
====Dosage====
=====(Adults / Children 2-18 years)=====
* Allow 3 or 4 pellets to dissolve in the mouth 3 times a day until symptoms are relieved or as directed by a health professional.
|offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
 
<!--Non–Guideline-Supported Use (Pediatric)-->
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of {{PAGENAME}} in pediatric patients.
 
<!--Contraindications-->
|contraindications=
 
<!--Warnings-->
|warning=* Do not use if pellet-dispenser seal is broken.
* Stop use and ask a doctor if symptoms persist more than 3 days or worsen.
* If pregnant or breast-feeding, ask a health professional before use.
* Keep out of reach of children.
 
<!--Adverse Reactions-->
 
<!--Clinical Trials Experience-->
|clinicalTrials=* [[Diarrhea]]<ref name="pmid2860632">{{cite journal| author=Czajka PA, Russell SL| title=Nonemetic effects of ipecac syrup. | journal=Pediatrics | year= 1985 | volume= 75 | issue= 6 | pages= 1101-4 | pmid=2860632 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2860632  }} </ref>
* [[Stomach cramps]]
* [[Myalgia]]
* [[Lethargy]]<ref name="pmid2860632">{{cite journal| author=Czajka PA, Russell SL| title=Nonemetic effects of ipecac syrup. | journal=Pediatrics | year= 1985 | volume= 75 | issue= 6 | pages= 1101-4 | pmid=2860632 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2860632  }} </ref>
|drugInteractions=
 
<!--Use in Specific Populations-->
|useInPregnancyFDA=* If pregnant or breast-feeding, ask a health professional before use
|useInPregnancyAUS=* '''Australian Drug Evaluation Committee (ADEC) Pregnancy Category'''
 
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of {{PAGENAME}} in women who are pregnant.
|useInLaborDelivery=There is no FDA guidance on use of {{PAGENAME}} during labor and delivery.
|useInNursing=* If pregnant or breast-feeding, ask a health professional before use
|useInPed=There is no FDA guidance on the use of {{PAGENAME}} with respect to pediatric patients.
|useInGeri=There is no FDA guidance on the use of {{PAGENAME}} with respect to geriatric patients.
|useInGender=There is no FDA guidance on the use of {{PAGENAME}} with respect to specific gender populations.
|useInRace=There is no FDA guidance on the use of {{PAGENAME}} with respect to specific racial populations.
|useInRenalImpair=There is no FDA guidance on the use of {{PAGENAME}} in patients with renal impairment.
|useInHepaticImpair=There is no FDA guidance on the use of {{PAGENAME}} in patients with hepatic impairment.
|useInReproPotential=There is no FDA guidance on the use of {{PAGENAME}} in women of reproductive potentials and males.
|useInImmunocomp=There is no FDA guidance one the use of {{PAGENAME}} in patients who are immunocompromised.
 
<!--Administration and Monitoring-->
|administration=* Oral
 
 
|monitoring=There is limited information regarding <i>Monitoring</i> of {{PAGENAME}} in the drug label.
 
 
 
<!--IV Compatibility-->
|IVCompat=There is limited information regarding <i>IV Compatibility</i> of {{PAGENAME}} in the drug label.
 
<!--Overdosage-->
|overdose=There is limited information regarding <i>Overdose</i> of {{PAGENAME}} in the drug label.
 
<!--Pharmacology-->
 
<!--Drug box 2-->
|drugBox=<!--Mechanism of Action-->
|mechAction=
 
<!--Structure-->
|structure======ACTIVE INGREDIENT HPUS=====
IPECACUANHA 3X
 
(Ipecac)
 
=====INACTIVE INGREDIENTS=====
Lactose, sucrose.
 
 
 
<!--Pharmacodynamics-->
|PD=There is limited information regarding <i>Pharmacodynamics</i> of {{PAGENAME}} in the drug label.
 
<!--Pharmacokinetics-->
|PK=There is limited information regarding <i>Pharmacokinetics</i> of {{PAGENAME}} in the drug label.
 
<!--Nonclinical Toxicology-->
|nonClinToxic=There is limited information regarding <i>Nonclinical Toxicology</i> of {{PAGENAME}} in the drug label.
 
<!--Clinical Studies-->
|clinicalStudies=There is limited information regarding <i>Clinical Studies</i> of {{PAGENAME}} in the drug label.
 
<!--How Supplied-->
|howSupplied=
|storage=* Store at room temperature.
|packLabel=====LABEL====
: [[File:Ipecacuanha PDP.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
 
====Ingredients and Appearance====
: [[File:Ipecacuanha Ing and App.png|thumb|none|600px|This image is provided by the National Library of Medicine.]]
 
<!--Patient Counseling Information-->
|fdaPatientInfo=* QUESTIONS?
: 1-800-404-4666
|alcohol=* Alcohol-{{PAGENAME}} interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
 
<!--Brand Names-->
|brandNames=* IPECACUANHA®<ref>{{Cite web | title = Ipecacuanha pellet | url = http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6dde3c03-7b16-4de5-aec1-e9fda7e2fba0}}</ref>


'''Ipecacuanha''' (''Psychotria ipecacuanha'') of family [[Rubiaceae]] is a [[flowering plant]], the root of which is most commonly used to make [[syrup of ipecac]], a powerful [[emetic]]. Its name comes from the [[Tupi language|Tupi]] ''i-pe-kaa-guéne'', translated as 'road-side sick-making plant'. It is native to [[Brazil]]. The plant had been assigned different names by various [[botany|botanists]]; several scientific names including ''Cephaelis acuminata'', ''Cephaelis ipecacuanha'', ''Psychotria ipecacuanha'', and ''Uragoga ipecacuanha'' were used.
<!--Look-Alike Drug Names-->
|lookAlike=


Ipecacuanha was first introduced to [[Europe]] in 1672, by a traveler named Legros. Legros imported some quantity of the root to [[Paris, France|Paris]] from [[South America]]. In 1680, a Parisian merchant named Garnier possessed some 68 kilograms (150 pounds) of the substance and informed a physician named [[Helvetius]] of its power in the treatment of [[dysentery]]. Helvetius was granted sole right to vend the remedy by [[Louis XIV of France|Louis XIV]], but sold the secret to the [[French government]], who made the [[formula]] public in 1688.
<!--Drug Shortage Status-->
|drugShortage=
}}
<!--Pill Image-->


The part of ipecacuanha used in medicine is the root, which is simple or divided into a few branches, flexuous, about as thick as a goose [[quill]], and is composed of rings of various size, somewhat fleshy when fresh, and appearing as if closely strung on a central woody cord.  The different kinds known in commerce (gray, red, brown) are all produced by the same plant, the differences arising from the age of the plant, the mode of drying, etc. Various other plants are used as substitutes for it.


Ipecacuanha is useful as an [[emetic]] when it is necessary to unload the stomach in cases where there is great debility or in childhood. As a [[nauseant]], [[expectorant]], and [[diaphoretic]], it is prescribed in [[bronchitis]], etc., and in disorders in which it is desired to increase the actions of the skin. The most useful preparations are the [[syrup of ipecac|wine of ipecacuanha]] and [[Dover's powder]].


==Similar plants==
<!--Label Display Image-->
Ipecacuanha is a slow-growing plant, which reduces its commercial appeal as a crop plant. It is seldom cultivated in [[South America]], but it has been cultivated in [[India]] and elsewhere. 


Botanical naming practices vary and change a great deal, thus the following is a generalized listing of plants which have at some point in time been employed as substitutes for ipecacuanha.  Some of the names of the species may be obsolete.


*Brazilian or Rio ipecacuanha: ''Cephaelis ipecacuanha''{{Verify source|date=September 2007}}
*Cartagena or Colombia ipecacuanha: ''Cephaelis acuminata''{{Verify source|date=September 2007}}
*Wild ipecacuanha: ''Euphorbia ipecacuanhae'' of [[North America]]
*[[Venezuela|Venezuelan]] plant: ''Sarcostemma glacum'', of the family [[Asclepiadaceae]]
*''Tylophora asthmatica'' was used in [[India]]
*''Gillenia stipulata'' was called American ipecac
*''Richardsonia pilosa, Richardsonia rosea, Psychotria emetica'' and various species of ''Ionidium'' have been employed, too.


==Other==
*Ipecacuanha was the name of the ship that initially rescued the character Edward Prendick in the novel ''[[The Island of Doctor Moreau]]'' written by [[H. G. Wells]]. The ship he had been on, the Lady Vain, collided with rocks, and he was left to float in a dingy until he was rescued eight days later.
*[[Guybrush Threepwood]] used Ipecacuanha syrup (made by combining a flower from the Ipecacuanha with maple syrup) in order to escape from the giant snake that swallowed him in ''[[The Curse of Monkey Island|Monkey Island 3: The Curse of Monkey Island]]'' [[videogame]].


==External links==
;Therapeutic classification
*{{ATC|R05|CA04}}


{{Cough and cold preparations}}
<!--Category-->
{{Antidotes}}
[[Category:Rubiaceae]]
[[Category:Flora of Brazil]]
[[Category:Medicinal plants]]


[[de:Brechwurzel]]
[[Category:Drug]]
[[es:Psychotria ipecacuanha]]
[[fr:Ipécacuanha]]
[[ms:Pokok Ipecacuanha]]
[[ja:トコン]]
[[pl:Ipekakuana prawdziwa]]
[[pt:Ipecacuanha]]
[[sv:Kräkrot]]
{{WikiDoc Sources}}

Latest revision as of 21:12, 4 March 2015

Ipecacuanha
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rabin Bista, M.B.B.S. [2]

Disclaimer

WikiDoc MAKES NO GUARANTEE OF VALIDITY. WikiDoc is not a professional health care provider, nor is it a suitable replacement for a licensed healthcare provider. WikiDoc is intended to be an educational tool, not a tool for any form of healthcare delivery. The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. WikiDoc does not promote the administration of any medication or device that is not consistent with its labeling. Please read our full disclaimer here.
NOTE: Most over the counter (OTC) are not reviewed and approved by the FDA. However, they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

Overview

Ipecacuanha is a OTC emetic that is FDA approved for the treatment of of Poisoning, acute by inducing vomiting. Common adverse reactions include Diarrhea, Stomach cramps, Myalgia and Lethargy.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Indications

Dosage

(Adults / Children 2-18 years)
  • Allow 3 or 4 pellets to dissolve in the mouth 3 times a day until symptoms are relieved or as directed by a health professional.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Ipecacuanha in adult patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Ipecacuanha in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Indications

  • Poisoning, acute[1]

Dosage

(Adults / Children 2-18 years)
  • Allow 3 or 4 pellets to dissolve in the mouth 3 times a day until symptoms are relieved or as directed by a health professional.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information regarding Off-Label Guideline-Supported Use of Ipecacuanha in pediatric patients.

Non–Guideline-Supported Use

There is limited information regarding Off-Label Non–Guideline-Supported Use of Ipecacuanha in pediatric patients.

Contraindications

There is limited information regarding Ipecacuanha Contraindications in the drug label.

Warnings

There is limited information regarding Ipecacuanha Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

Postmarketing Experience

There is limited information regarding Ipecacuanha Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Ipecacuanha Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • If pregnant or breast-feeding, ask a health professional before use


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Ipecacuanha in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Ipecacuanha during labor and delivery.

Nursing Mothers

  • If pregnant or breast-feeding, ask a health professional before use

Pediatric Use

There is no FDA guidance on the use of Ipecacuanha with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Ipecacuanha with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Ipecacuanha with respect to specific gender populations.

Race

There is no FDA guidance on the use of Ipecacuanha with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Ipecacuanha in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Ipecacuanha in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Ipecacuanha in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Ipecacuanha in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral

Monitoring

There is limited information regarding Monitoring of Ipecacuanha in the drug label.

IV Compatibility

There is limited information regarding IV Compatibility of Ipecacuanha in the drug label.

Overdosage

There is limited information regarding Overdose of Ipecacuanha in the drug label.

Pharmacology

There is limited information regarding Ipecacuanha Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Ipecacuanha Mechanism of Action in the drug label.

Structure

ACTIVE INGREDIENT HPUS

IPECACUANHA 3X

(Ipecac)

INACTIVE INGREDIENTS

Lactose, sucrose.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Ipecacuanha in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Ipecacuanha in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Ipecacuanha in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Ipecacuanha in the drug label.

How Supplied

There is limited information regarding Ipecacuanha How Supplied in the drug label.

Storage

  • Store at room temperature.

Images

Drug Images

{{#ask: Page Name::Ipecacuanha |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

LABEL

This image is provided by the National Library of Medicine.

Ingredients and Appearance

This image is provided by the National Library of Medicine.

{{#ask: Label Page::Ipecacuanha |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

  • QUESTIONS?
1-800-404-4666

Precautions with Alcohol

  • Alcohol-Ipecacuanha interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

  • IPECACUANHA®[4]

Look-Alike Drug Names

There is limited information regarding Ipecacuanha Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ 1.0 1.1 Krenzelok EP, Dean BS (1985). "Syrup of ipecac in children less than one year of age". J Toxicol Clin Toxicol. 23 (2–3): 171–6. PMID 2865374.
  2. ↑ Litovitz T (1988). "In defense of retaining ipecac syrup as an over-the-counter drug". Pediatrics. 82 (3 Pt 2): 514–6. PMID 2900493.
  3. ↑ 3.0 3.1 Czajka PA, Russell SL (1985). "Nonemetic effects of ipecac syrup". Pediatrics. 75 (6): 1101–4. PMID 2860632.
  4. ↑ "Ipecacuanha pellet".
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