Property:AnswerDExp
Jump to navigation
Jump to search
W
Collagen type 4 is also known as basal membrane or basal lamina. It is needed for tissue integrity and cellular attachments. It is not more abundant in healed wounds. +
This refers to the glomerular basement membrane which is usually spared in MCD. It is involved in the pathogenesis of Alport syndrome and membranoproliferative glomerulonephritis among others. +
This refers to the glomerular basement membrane which is usually defective in Alport's syndrome due to a mutation affecting the type 4 collagen. +
Defects in CD40L on T-helper cells is seen in Hyper-IgM syndrome leading to an inability to switch Ig classes. It is not seen in WAS. +
Although drug efflux can be seen as a mechanism of resistance to macrolides, it is minor compared to rRNA methylation. +
This step refers to the cleavage of the terminal regions of procollagen. It is not affected by vitamin C deficiency. +
This step refers to the cleavage of the terminal regions of procollagen. It is not affected in Ehlers-Danlos syndrome. +
Copper is important for the proper functioning of lysyl-oxidase an enzyme defective in certain forms of Ehlers-Danlos syndrome. +
This refers to the glomerular basement membrane which is usually spared in IgA nephropathy. It is involved in the pathogenesis of Alport syndrome and membranoproliferative glomerulonephritis among others. +
Bile outlet obstruction would usually lead to conjugated hyperbilirubinemia with deranged LFTs. +
Bile outlet obstruction would usually lead to conjugated hyperbilirubinemia with deranged LFTs. +
'''Incorrect''' Endocarditis is often accompanied by fever , and presents as a new murmur or change in an existing murmur. It is diagnosed by blood cultures and vegetations on cardiac valves on echocardiography. The patient in this vignette does not display fever or other acute infective symptoms +
'''Incorrect''' Ejection fraction less than 60% and left ventricular end systolic diameter more than 40mm is the criteria +
Aortic regurgitation is characterize by a diastolic murmur that gradually decreases in intensity (decrescendo murmur) +
'''Incorrect''' Surgery should be performed only when appropriate criteria is met, not in all symptomatic patients. Medical treatment is the best initial therapy. +
'''Incorrect''' Musset’s sign refers to head bobbing with each pulse. This sign is also seen in aortic regurgitation. +
The profile may be seen early in a normal menstrual cycle, when levels of FSH are high and and LH response has not yet mounted. +
Polyarteritis nodosa (PAN) is a small and medium-size vasculitis that affects the kidneys, heart, and GI tract. Approximately 25% of patients with PAN have positive a hepatitis B serum antigen. +