Property:AnswerEExp
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Although aspirin blocks thromboxane A2 release, clopidogrel does not inhibit ADP release. Clopidogrel is responsible for blocking the ADP receptors that mediate GpIIbIIIa expression. +
PDE5 inhibitors cause accumulation of cGMP helping cure erectile dysfunction. PDE3 inhibitors are not used in patients with ED. +
PAN is not associated with coronary artery vasculitis. Classically, the coronary arteries are involved in Kawasaki disease and may develop aneurysms. +
Migration defects are classically seen with neural crest cells. Examples include aotricopulmonary septum formation defects and Hirschprung disease. +
This demonstrates a pronounced thickening of the colonic wall in patients with pseudomembranous colitis. +
Cognitive impairment associated with subdural hematoma is usually insidious and most times associated with a history of trauma to the head – falls, etc. There was no history of trauma in this patient. +
HIV-associated dementia, a.k.a. Aids Dementia Complex (ADC) is a metabolic encephalopathy induced by HIV infection and fueled by immune activation of brain macrophages and microglia. These cells are actively infected with HIV and secrete neurotoxins of both host and viral origin. The essential features are disabling cognitive impairment accompanied by motor dysfunction, speech problems and behavioral change. Cognitive impairment is characterized by mental slowness, trouble with memory and poor concentration. Motor symptoms include a loss of fine motor control leading to clumsiness, poor balance and tremors. Behavioral changes may include apathy, lethargy and diminished emotional responses and spontaneity. Histopathologically, it is identified by the infiltration of monocytes and macrophages into the central nervous system (CNS), gliosis, pallor of myelin sheaths, abnormalities of dendritic processes and neuronal apoptosis. ADC typically occurs after years of HIV infection and is associated with low CD4+ T cell levels and high plasma viral loads. It is sometimes seen as the first sign of the onset of AIDS. HAART may not only prevent or delay the onset of ADC in people with HIV infection; it can also improve mental function in people who already have ADC.
This is an example of an irreversible cause of dementia. +
All patients must be managed in the ICU post-IV TPA for close monitoring of blood pressure and bleeding complications. +
Incorrect
Lipid profile will not establish the diagnosis of CAD, but will be used subsequently to follow up this patient. +