Property:AnswerEExp
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An example of a gene that encodes a cytokine receptor is ''C-KIT'' oncogene whose mutation is associated with development of gastrointestinal stromal tumors (GIST). ''JAK1'' is a gene that encodes a cytokine receptor and is mutated in polycythemia vera, a myeloproliferative disorder. +
Macrophage infiltration and granulation tissue are observed starting 3 days post-MI. These findings persist to approximately 15 days post-MI. +
Schistocytes or helmet cells are fragmented red blood cells that are commonly seen in hemolysis, such as in cases of disseminated intravascular coagulopathy (DIC), thrombotic thrombocytopenic purport (TTP) or even in traumatic hemolysis, such as in patients with mechanical heart valves. +
INF-alpha is not a main mediator of cachexia syndrome. Nonetheless, IFN-gamma is frequently activated in cachexia. IFN-gamma is normally secreted by CD4+ Th1 cells and serves to activate nearby macrophages in the presence of a viral infection. The interferons as a family have direct antiviral activity and help to induce the expression of MHC-class II in virally infected cells. +
Carcinoid tumors are usually characterized by nests or cords of uniform cells with central nuclei. +
Chronic monoarthritis and migratory polyarthritis is a typical manifestation of late Lyme disease occurring several months to years after the initial tick bite. +
p53 gene mutations are responsible for the development of several cancers including osteosarcoma, breast and colon cancer. +
CD14 is a macrophage bound receptor that binds to the LPS endotoxin causing an immune reaction. +
Factor IX deficiency is seen in patients with Hemophilia A. Patients are at risk for hemarthrosis and heavy bleeding after trauma. +
MM is usually associated with rouleaux formation on peripheral smear due to the associated hypergammaglobulinemia. +