Property:AnswerCExp

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Vancomycin is a first line therapy for CA-MRSA. There are no contraindications for its use in our patient.  +
Leucovorin is usually co-administered with pyrimethamine to decrease the risk of myelosuppression. It has no synergistic activity.  +
Hyperphosphorylation of the Rb protein renders it inactive and allows the progression into neoplasia as observed in Plate A.  +
Collagen type 3 is important in granulation tissue during wound healing. It is replaced by collagen type 1 seen in healed scars. Collagen type 3 would be more abundant in the larger unhealed ulcer in our patient.  +
This refers to the podocyte. Although the foot processes of the podocyte are effaced, the cell itself is not affected.  +
This refers to the glomerular podocyte. It is usually affected in focal segmental glomerulosclerosis.  +
Lysosomal trafficking defects are seen in Chédiak–Higashi syndrome, not in WAS.  +
Beta-lactamase inhibitors like tazobactam, clavulanic acid, and sulbactam are used with penicillin antibiotics to inhibit destruction of the beta-lactam ring by beta-lactamase producing bacteria.  +
This is the mechanism of action of tetracyclines.  +
This step refers to collagen triple helix (procollagen) formation. It is defective in osteogenesis imperfecta. It is not affected by vitamin C deficiency.  +
This step refers to collagen triple helix (procollagen) formation. It is defective in osteogenesis imperfecta. It is not affected in Ehlers-Danlos syndrome.  +
Zinc is very important in the formation of zinc fingers which constitute parts of some transcription factors. It has no function with lysyl-oxidase.  +
This refers to the podocyte. It is affected focal segmental glomerulosclerosis, not in IgA nephropathy (at least in early stages)  +
Decreased bilirubin uptake by the liver is the main mechanism behind Gilbert syndrome.  +
Decreased bilirubin uptake by the liver is the main mechanism behind Gilbert syndrome not Crigler-Najjar.  +
Diastolic murmur after an opening snap is the classic presentation of mitral stenosis  +
Surgery is indicated when ejection fraction drops below 60% and left ventricular end systolic diameter is more than 40mm.  +
'''Incorrect''' Mitral valve prolapse is seen in Marfans or Ehlers- Danlos syndrome and is characterized by a mid systolic click on cardiac auscultation  +
'''Incorrect''' Angiotensisn converting enzyme inhibitors, angiotenisn receptor blockers and nifedipine are the best initial therapy when ejection fraction is more than 55%  +
'''Incorrect''' In aortic regurgitation, a murmur can heard over the femoral artery (duroziez’s sign)  +