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The method is truly accurate (valid) but not precise (reproducible) because of the absence of a systematic error and presence of random error, respectively. +
Lichen planus is a chronic inflammatory disease that affects the skin and the mucous membrane. It is associated with chronic hepatitis C infection. It may affect the skin, oral cavity, genitalia, scalp, nails, or esophagus. The clinical features of cutaneous lichen planus are pruritus, purple, polygonal papules, and plaques (6 Ps) with Wickham striae (white striations). Diagnosis is by biopsy that demonstrates sawtooth lymphocytic infiltration at the dermal-epidermal junction. First line therapy is topical corticosteroids. +
Skeletal muscle contains GLUT-4 but they require the action of insulin for glucose uptake +
Correct. Behçet's disease a.k.a. Behçet's syndrome is a chronic multi-systemic vasculitis characterized by mucocutaneous, articular, neurological, gastrointestinal and ocular lesions. It involves a triad of symptoms that include recurring mouth ulcers (aphthous ulcers, canker sores), genital ulcers, and uveitis. +
Incorrect. Bulimia nervosa is a psychiatric eating disorder characterized by repeated bouts of overeating and an excessive preoccupation with the control of body weight, leading to a pattern of overeating followed by vomiting or use of purgatives, laxatives, diuretics, enemas, or in some instances, over-exercising. It is common among teen females and women, but boys and men could also have it also.
Diagnostic Criteria – According to the American Psychiatric Association, a diagnosis of bulimia must meet all the following criteria:
* Recurrent episodes of binge eating. An episode of binge eating is characterized by both of the following:
- Eating, in a discrete period of time (e.g., within any 2-hour period), an amount of food that is definitely larger than most people would eat during a similar period of time and under similar circumstances.
- A sense of lack of control over eating during the episode (e.g., a feeling that one cannot stop eating or control what or how much one is eating.
* Recurrent inappropriate compensatory behavior in order to prevent weight gain, such as self-induced vomiting; misuse of laxatives, diuretics, enemas, or other medications; fasting; or excessive exercise.
* The binge eating and inappropriate compensatory behaviors both occur, on average, at least twice a week for 3 months.
* Self-evaluation is unduly influenced by body shape and weight.
* The disturbance does not occur exclusively during episodes of anorexia nervosa.
The management of bulimia involves the combination of cognitive behavioral therapy, SSRIs such as fluoxetine, as well as patient and family support groups, are effective. +
The activity of the direct pathway is reduced due to a reduced release of D1, which normally bind to D1 receptors of the striatum. +
The CSF of a patient with herpes encephalitis is characterized by an unchanged or slightly decreased level of glucose. Glucose level is significantly decreased in bacterial infections of the CNS. +
Cimetidine inhibits tubular secretion of creatinine. As such, creatinine clearance will decrease but calculated GFR based on creatinine will become closer to the true GFR, which is calculated by measuring inulin clearance. +
Secondary hypertension is defined as high blood pressure due a systemic cause. Generally, management of the primary cause helps reduce the high blood pressure. +
Thyrotroph ademonas of the pituitary are characterized by nuclei that are indented associated with large nucleoli and long cytoplasmic processes. Thyrotroph adenomas may present with symptoms of thyrotoxicosis. Urinary 5-HIAA is not typically seen in such adenomas +
Reye's syndrome is not associated with collagen defects or abnormal mitotic activity in the liver. +
Lanosterol is a precursor for the production of ergosterol. Mutations of lanosterol are not associated with antifungal resistance. +
Nifurtimox is the treatment of choice for ''Trypanosoma cruzi'', the causative agent of Chagas disease. It is not associated with myelosuppresion. A common side effect is anorexia seen in approximately 10% of patients and sometimes leading to discontinuation of therapy. +