View source for Zinc finger FYVE domain-containing protein 9

{{Infobox_gene}}

'''Zinc finger FYVE domain-containing protein 9''' or '''SARA''' (<u>S</u>MAD <u>a</u>nchor for <u>r</u>eceptor <u>a</u>ctivation) is a [[protein]] that in humans is encoded by the '''''ZFYVE9''''' [[gene]].<ref name="pmid9865696">{{cite journal | vauthors = Tsukazaki T, Chiang TA, Davison AF, Attisano L, Wrana JL | title = SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor | journal = Cell | volume = 95 | issue = 6 | pages = 779–791 |date=December 1998 | pmid = 9865696 | doi =10.1016/S0092-8674(00)81701-8 | url = | issn = }}</ref> SARA contains a double zinc finger ([[FYVE domain]]).

SARA is an anchoring protein involved in [[TGF beta signaling pathway#SMAD phosphorylation|TGF beta signaling]]. It binds to the MH2 domain of the [[R-SMAD]]s [[SMAD2]] and [[SMAD3]] as well as the type I TGF beta receptors.<ref name="pmid15356634">{{cite journal | vauthors = Lin HK, Bergmann S, Pandolfi PP | title = Cytoplasmic PML function in TGF-beta signalling | journal = Nature | volume = 431 | issue = 7005 | pages = 205–211 |date=September 2004 | pmid = 15356634 | doi = 10.1038/nature02783 | url = | issn = }}</ref> It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates form SARA and the receptor and binds a coSMAD where they enter the nucleus as [[transcription factor]]s.

==References==
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{{TGF beta signaling}}

[[Category:Developmental genes and proteins]]
[[Category:FYVE domain]]


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