View source for NPR1

{{Infobox_gene}}
'''Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)''', also known as '''NPR1''', is an [[atrial natriuretic peptide receptor]]. In humans it is encoded by the ''NPR1'' [[gene]].

== Function ==

NPR1 is a membrane-bound [[guanylate cyclase]] that serves as the receptor for both atrial and brain natriuretic peptides ([[atrial natriuretic peptide|ANP]] and [[brain natriuretic peptide|BNP]], respectively).<ref>{{cite web | title = Entrez Gene: NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4881| accessdate = }}</ref>

It is localized in the kidney<ref name=biogps>[http://biogps.gnf.org/#goto=genereport&id=4881 BioGPS > NPR1] Retrieved Nov 2010 {{webarchive |url=https://web.archive.org/web/20101127041532/http://biogps.gnf.org/#goto=genereport&id=4881 |date=November 27, 2010 }}</ref> where it results in [[natriuresis]] upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and [[adipocytes]].<ref name=biogps/>

==See also==
* [[Atrial natriuretic peptide receptor]]

==References==
{{reflist}}

==Further reading==
{{refbegin | 2}}
*{{cite journal  | author=Pandey KN |title=Intracellular trafficking and metabolic turnover of ligand-bound guanylyl cyclase/atrial natriuretic peptide receptor-A into subcellular compartments. |journal=Mol. Cell. Biochem. |volume=230 |issue= 1–2 |pages= 61–72 |year= 2002 |pmid= 11952097 |doi=10.1023/A:1014240006767  }}
*{{cite journal   |vauthors=Lucarelli K, Iacoviello M, Dessì-Fulgheri P, etal |title=[Natriuretic peptides and essential arterial hypertension] |journal=Italian Heart Journal Supplement |volume=3 |issue= 11 |pages= 1085–91 |year= 2003 |pmid= 12506509 |doi=  }}
*{{cite journal  | author=Pandey KN |title=Internalization and trafficking of guanylyl cyclase/natriuretic peptide receptor-A |journal=Peptides |volume=26 |issue= 6 |pages= 985–1000 |year= 2005 |pmid= 15911067 |doi= 10.1016/j.peptides.2004.12.020 }}
*{{cite journal  |vauthors=Garg R, Pandey KN |title=Regulation of guanylyl cyclase/natriuretic peptide receptor-A gene expression |journal=Peptides |volume=26 |issue= 6 |pages= 1009–23 |year= 2005 |pmid= 15911069 |doi= 10.1016/j.peptides.2004.09.022 }}
{{refend}}

==External links==
* {{MeshName|NPR1+protein,+human}}

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{{Neuropeptide receptors}}
{{Enzyme-linked receptors}}
{{Phosphorus-oxygen lyases}}
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[[Category:EC 4.6.1]]


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