View source for Metaclazepam

{{Drugbox|
|IUPAC_name = 7-bromo-5-(2-chlorophenyl)-2-(methoxymethyl) -1-methyl-2,3-dihydro-1,4-benzodiazepine
| image=Metaclazepam.svg
| width=180
| CAS_number=84031-17-4
| ATC_prefix=
| ATC_suffix=
| ATC_supplemental=
| PubChem=71272
| DrugBank=
| C=18 | H=18 | Br=1 | Cl=1 | N=2 | O=1
| molecular_weight = 393.705
| bioavailability= 
| metabolism = 
| elimination_half-life= 
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| pregnancy_category =
| legal_status = 
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}}

'''Metaclazepam''' (Talis) is a drug which is a [[benzodiazepine]] derivative. It is a relatively selective [[anxiolytic]] with less [[sedative]] or [[muscle relaxant]] properties than other benzodiazepines such as [[diazepam]] or [[bromazepam]].<ref>Buschmann G, Kuhl UG, Rohte O. General pharmacology of the anxiolytic compound metaclazepam in comparison to other benzodiazepines. ''Arzneimittelforschung''. 1985;35(11):1643-55.</ref>

Metaclazepam is slightly more effective as an anxiolytic than bromazepam,<ref>Bilone F, Roncari R. A double-blind comparison of the anxiolytic activity of two benzodiazepines, metaclazepam and bromazepam, in anxiety neurosis. ''Current Medical Research and Opinion''. 1988;11(1):45-7.</ref> or diazepam,<ref>Laakmann G, Blaschke D, Hippius H, Schewe S. Double-blind study of metaclazepam versus diazepam treatment of outpatients with anxiety syndrome. ''Pharmacopsychiatry''. 1989 May;22(3):120-5.</ref> with a 15mg dose of metaclazepam equivalent to 4mg of bromazepam.<ref>Marano P, Patti F, Nicoletti F. Controlled study on the anxiolytic activity of a newly-developed benzodiazepine, metaclazepam. ''Current Medical Research and Opinion''. 1988;11(1):41-4.</ref> 





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==References==
<references/>

{{Benzodiazepines}}

[[Category:Benzodiazepines]]
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